Undergraduate |
Fudan University, Shanghai, China |
|
1987 |
Bachelor of Science |
Graduate |
University of Vermont, Burlington, VT |
|
1994 |
Ph.D. in Zoology/Molecular Biology |
Fellowship |
Washington University School of Medicine, St. Louis, MO |
|
1999 |
Bone Biology |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Professor |
Center |
Biomatrix Eng Regen Med (BERM) Ctr |
Biomatrix Eng Regen Med (BERM) Ctr |
Professor |
Center |
Cell Adhesion & Matrix Research Center |
Cell Adhesion & Matrix Research Center |
Professor |
Center |
Center for Biophysical Sciences/Engineering |
Center for Biophysical Sciences/Engineering |
Professor |
Center |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor |
Center |
UAB Immunology Institute |
UAB Immunology Institute |
Professor |
|
Cancer Biology |
Immunology |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Ashley JW, Shi Z, Zhao H, Li X, Kesterson RA, Feng X (2011) Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. PLoS One. 6(10):e25838. |
21991369 |
Cheng J, Liu J, Shi Z, Jules J, Xu D, Luo S, Wei S, Feng X (2012) Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis. J Interferon Cytokine Res. 32(1):34-45. |
22142221 |
Jules J, Zhang P, Ashley JW, Wei S, Shi Z, Liu J, Michalek SM, Feng X (2012) Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis. J Biol Chem. 287(19):15728-38. |
22416138 |
MohanKumar K, Kaza N, Jagadeeswaran R, Garzon SA, Bansal A, Kurundkar AR, Namachivayam K, Remon JI, Bandepalli CR, Feng X, Weitkamp JH, Maheshwari A (2012) Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model. Am J Physiol Gastrointest Liver Physiol. 303(1):G93-102. |
22538401 |
Izawa T, Zou W, Chappel JC, Ashley JW, Feng X, Teitelbaum SL (2012) c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton. Mol Cell Biol. 32(14):2943-53. |
22615494 |
Sawant A, Deshane J, Jules J, Lee CM, Harris BA, Feng X, Ponnazhagan S (2013) Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. Cancer Res. 73(2):672-82. |
23243021 |
McCoy EM, Hong H, Pruitt HC, Feng X (2013) IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells. BMC Cancer. 13:16. |
23311882 |
Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Ashley JW, Meleth S, Feng X, Siegal GP, Douglas JT (2013) Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model. Lab Invest. 93(3):268-78. |
23358109 |
Xia WF, Tang FL, Xiong L, Xiong S, Jung JU, Lee DH, Li XS, Feng X, Mei L, Xiong WC (2013) Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J Cell Biol. 200(6):821-37. |
23509071 |
Hong H, Shi Z, Qiao P, Li H, McCoy EM, Mao P, Xu H, Feng X, Wang S (2013) Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process. Biochem Biophys Res Commun. 440(4):545-50. |
24103757 |
Chu GC, Zhau HE, Wang R, Rogatko A, Feng X, Zayzafoon M, Liu Y, Farach-Carson MC, You S, Kim J, Freeman MR, Chung L (2014) RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization. Endocr Relat Cancer. 21: 311-26 |
24478054 |
Jules J and Feng X (2014) In vitro investigation of the roles of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 in murine osteoclastogenesis. Methods Mol Biol. 1155:109-23. |
24788177 |
Zhao D, Shi Z, Warriner AH, Qiao P, Hong H, Wang Y, Feng X. Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis. PLoS One. 2014 Jul 17;9(7):e102706. |
25032991 |
Feng X and Teitelbaum SL (2013) Osteoclasts: New Insights. Bone Research. 1 (1) 11-26 |
26273491 |
Jules J, Wang S, Shi Z, Liu J, Wei S, Feng X (2015) The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis. J Biol Chem. 290(39):23738-50. |
26276390 |
Chen Z, Su L, Xu Q, Katz J, Michalek SM, Fan M, Feng X, Zhang P (2015) IL-1R/TLR2 through MyD88 divergently modulates osteoclastogenesis through regulation of nuclear factor of activated T cells c1 (NFATc1) and B lymphocyte-induced maturation protein-1 (Blimp1). J Biol Chem. 290(50):30163-74. |
26483549 |
Jules J, Chen W, Feng X, Li YP. (2016) CCAAT/enhancer binding protein α (C/EBPα) is important for osteoclast differentiation and activity J Biol Chem. 291(31):16390-403 |
27129246 |
Jules J, Chen W, Feng X, Li YP (2018) C/EBPα is regulated by the RANK cytoplasmic IVVY535-538 motif and stimulates osteoclastogenesis more strongly than c-Fos. J Biol Chem. 293(4):1480-1492. |
29122885 |
Li Y, Shi Z, Jules J, Chen S, Kesterson RA, Zhao D, Zhang P, Feng X (2019) Specific RANK cytoplasmic motifs drive osteoclastogenesis. J Bone Miner Res. 34:1938-1951 |
31173390 |
Cai X, Li Z, Zhao Y, Katz J, Michalek SM, Feng X, Li Y, Zhang P (2020) Enhanced dual function of osteoclast precursors following calvarial Porphyromonas gingivalis infection. J Periodontal Res 55(3):410-425 |
31944305 |
Zhao Y, Li Z, Su L, Ballesteros-Tato A, Katz J, Michalek S, Feng X, Zhang P (2020) Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection Journal of Leukocyte Biology, 108(4):1037-1050 |
33463750 |
Paesen GC, Feng X, Happ GM (1996) Structure of a D-protein gene and amino-acid sequences of the highly repetitive D-proteins secreted by the accessory glands of the mealworm beetle. Biochim Biophys Acta. 1293(2):171-6. |
8620026 |
Cao X, Teitelbaum SL, Zhu HJ, Zhang L, Feng X, Ross FP (1996) Competition for a unique response element mediates retinoic acid inhibition of vitamin D3-stimulated transcription. J Biol Chem. 271(34):20650-4. |
8702813 |
Feng X, Happ GM (1996) Isolation and sequencing of the gene encoding Sp23, a structural protein of spermatophore of the mealworm beetle, Tenebrio molitor. Gene. 179(2):257-62. |
8972909 |
Feng X, Teitelbaum SL, Quiroz ME, Towler DA, Ross FP (1999) Cloning of the murine beta5 integrin subunit promoter. Identification of a novel sequence mediating granulocyte-macrophage colony-stimulating factor-dependent repression of beta5 integrin gene transcription. J Biol Chem. 274(3):1366-74. |
9880508 |
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