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Faculty Detail    
Campus Address NP 3546 Zip 6823
Phone  205-975-8317
Other websites

American Board of Pathology certified in Anatomic Pathology and Clinical Pathology  2010 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor
Center  Comprehensive Ctr for Healthy Aging  Comprehensive Ctr for Healthy Aging Assistant Professor

Biographical Sketch 
1. M.D., 09/1981- 07/1986, Zhejiang Medical University, Hangzhou, China
2. Ph.D., 09/1989-12/1994, Zhejiang Medical University, Hangzhou, China
3. Pathology residency, Anatomic and Clinical Pathology, 07/2006-06/2010, University of Southern California, Keck School of medicine, Los Angeles, CA
4. Breast pathology fellowship, 07/2010-06/2011, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
5. Surgical pathology fellowship, 07/2011-12/2011, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Society Memberships
Organization Name Position Held Org Link
American Society for Clinical Pathology (ASCP)  Fellow 
Collage of American Pathologists (CAP)  Fellow 
United States & Canadian Academy of Pathology (USCAP)  Member 

Research/Clinical Interest
Cancer biomarker
My major clinical interest is on surgical pathology diagnosis, primarily in the subspecialty of breast pathology, genitourinary pathology and gastrointestianl pathology. My current research interests are mainly in two areas: (1) precision oncology and cancer biomarkers and (2) rapid molecular imaging for surgical margin surveillance. For the breast cancer biomarker study, we have been working on mining whole genome sequencing data from The Cancer Genome Atlas (TCGA) in order to characterize the genomic features of cancer histopathology. For the molecular imaging study, I have received a career development award from the UAB comprehensive Cancer Center to develop a novel lectin based, near infrared (NIR) optical imaging method that is capable of intraoperatively identifying positive surgical margins of breast lumpectomy.

Selected Publications 
Publication PUBMEDID
Cui X, Harada S, Shen D, Siegal GP, Wei S. The Utility of Phosphohistone H3 in Breast Cancer Grading. Appl Immunohistochem Mol Morphol. 2015 Jan 21. [Epub ahead of print]   25611243 
Tao YK, Shen D, Sheikine Y, Ahsen OO, Wang HH, Schmolze DB, Johnson NB, Brooker JS, Cable AE, Connolly JL, Fujimoto JG. Assessment of breast pathologies using nonlinear microscopy. Proc Natl Acad Sci U S A. 2014; 111(43): 15304-9  25313045 
Ma Y, Nix JW, Telford RC, Siegal G and Shen D. Extensive Urinary Malakoplakia with Lymph Node Involvement: A Case Report. Austin J Clin Pathol. 2014;1(3): 3.   
Reddy K, Hooper K, Frost A, Shen D, Monkemuller KE, Christein J, Ramesh J. Intraductal papillary carcinoma of common bile duct diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Endoscopy. 2014;46 Suppl 1:E248-9.   24853442 
Zheng Ping, Gene Siegal, Jonas Almeida, Stuart Schnitt and Dejun Shen. Mining genome sequencing data to identify the genomic features linked to breast cancer histopathology. J Pathology Informatics. 2014; 5: 3   24672738 
Rice MS, Tamimi RM, Connolly JL, Collins LC, Shen D, Pollak MN, Rosner B, Hankinson SE, Tworoger SS. Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II. Breast Cancer Res. 2012; 14(2): R44.  22414675 
Lee HC, Zhou C, Cohen DW, Mondelblatt AE, Wang Y, Aguirre AD, Shen D, Sheikine Y, Fujimoto JG, Connolly JL. Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues. J Urol. 2012;187(2): 691-9.   22177199 
He J, Whelan SA, Lu M, Shen D, Chung DU, Saxton RE, Faull KF, Whitelegge JP, Chang HR. Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response. Int J Proteomics. 2011;2011:896476.  22110952 
Yang C, Hayashida T, Forster N, Li C, Shen D, Maheswaran S, Chen L, Anderson KS, Ellisen LW, Sgroi D and Schmidt EV. The integrin alpha v-beta 3,5 ligand MFG-E8 is a p63/p73 target gene in triple negative breast cancers but exhibits suppressive functions in ER+ and erbB2+ breast cancers. Cancer Research. 2011; 71(3): 937-45.   21127199 
Yoon NK, Maresh EL, Shen D, Elshimali Y, Apple S, Horvath S, Mah V, Bose S, Chia D, Chang HR, and Goodglick L. Higher Levels of GATA3 Predict Better Survival in Women with Breast Cancer. Human Pathology, 2010 Dec; 41(12): 1794-801.  21078439  
He J, Shen D, Chung DU, Saxton RE, Whitelegge JP, Faull KF, Chang HR. Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy. Int J Oncol. 2009; 35(4): 683-92.   19724903 
Wu Y, Shen D, Chen Z, Clayton S, Vadgama JV. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007; 12(3): 593-612.  17195090 
He J, Gornbein J, Shen D, Lu M, Rovai LE, Shau H, Katz J, Whitelegge JP, Faull KF, Chang HR. Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry. Int J Oncol. 2007; 30(1): 145-54.  17143523 
Shen D, Nooraie F, Elshimali Y, Lonsberry V, He J, Bose S, Chia D, Seligson D, Chang HR, Goodglick L. Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis. Hum Pathol. 2006; 37(12): 1583-91.  16949910 
Vadgama JV, Scuric Z, Chakrabarti R, Marzo E, Shen D, Wu Y. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Int J Mol Med. 2006; 18(1): 129-39.  16786164 
Shen D, He J and Chang HR. In silico identification of breast cancer genes by combined multiple high throughput analyses. Int J of Mol Med, 2005; 15(2): 205-212  15647832 
Shen D, Chang HR, Chen Z, He J, Lonsberry V, Elshimali Y, Chia D, Seligson D, Goodglick D, Nelson S, and Gornbein J. Loss of annexin A1 expression in human breast cancer detected by multiple throughput analyses. Biochemical and Biophysical Research Communications, 2005; 326(1): 218-227  15567174 
He J, Shen D, O'Donnell MA, Chang HR. Induction of MUC1-specific cellular immunity by a recombinant BCG expressing human MUC1 and secreting IL2. Int J Oncol. 2002; 20(6): 1305-11.  12012014 

Breast pathology, biomarker, bioinformatics