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Faculty Detail    
Name ERIK ROBERSON
Patsy W. and Charles A. Collat Professor of Neuroscience
Director, Alzheimer's Disease Center
Co-Director, Center for Neurodegeneration and Experimental Therapeutics
Co-Director, McKnight Brain Institute
 
Campus Address SHEL 1110 Zip 2182
Phone
E-mail  eroberson@uab.edu
Other websites Roberson Lab Website
CNET Website
Alzheimer's Disease Center website
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurology   Neurology Chair Office Associate Professor
Secondary  Neurobiology  Neurobiology Associate Professor
Center  Neurology   Alzheimer's Disease Center Associate Professor
Center  Comprehensive Ctr for Healthy Aging  Comprehensive Ctr for Healthy Aging Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor
Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Associate Professor
Center  Neurology   Multiple Sclerosis Center Associate Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Medical Scientist Training Program 
Neuroscience 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Roberson is a neurologist and neuroscientist whose research is focused on age-related cognitive impairment. He received his A.B. with highest honors from Princeton University, then earned his M.D. and Ph.D in neuroscience at Baylor College of Medicine where he studied molecular mechanisms of learning and memory. He completed a residency in neurology at the University of California San Francisco, where he also served as Chief Resident in Neurology. After residency, he completed a clinical fellowship in behavioral neurology at UCSF and resumed basic research at the Gladstone Institute of Neurological Disease. He joined the neurology faculty at UCSF in 2005 and moved to UAB in 2008.

The Roberson lab studies the neurobiology of Alzheimer’s disease and frontotemporal dementia (FTD), using mouse models to understand the cellular and molecular mechanisms of these disorders and identify new therapeutic strategies, with a particular focus on tau and progranulin. His lab is part of the UAB Center for Neurodegeneration and Experimental Therapeutics (CNET), which Dr. Roberson leads along with Dr. Andrew West.

Dr. Roberson is also active in clinical research and patient care, directing the UAB Alzheimer’s Disease Center, leading clinical trials, caring for patients with memory disorders and dementia at the Kirklin Clinic, and co-directing the Evelyn F. McKnight Brain Institute for research on cognitive aging.

Society Memberships
Organization Name Position Held Org Link
American Academy of Neurology    http://www.aan.com 
American Neurological Association    http://myana.org 
International Society to Advance Alzheimer Research and Treatment    http://www.alz.org/professionals_and_researchers_istaart.asp 
Molecular and Cellular Cognition Society    http://www.molcellcog.org/ 
Society for Neuroscience    http://www.sfn.org 

Research/Clinical Interest
Title
Neurobiology of Alzheimer's Disease and Frontotemporal Dementia
Description
The Roberson lab studies the neurobiology of two common neurodegenerative disorders, Alzheimer Disease and Frontotemporal Dementia, with a focus on understanding the underlying cellular and molecular mechanisms that will lead to better treatments. We apply modern neuroscience approaches to study animal and cellular models of these conditions. We have shown that reducing expression of the microtubule-associated protein tau makes the brain resistant to Alzheimer-related impairments, and are using a variety of behavioral, electrophysiological, and biochemical approaches to better understand this protective effect. We are also studying animal models of frontotemporal dementia to understand how mutations in tau and progranulin cause the social and behavioral dysfunction seen in this condition.

Selected Publications 
Publication PUBMEDID
Matilla A, Roberson ED, Banfi S, Morales J, Armstrong DL, Burright EN, Orr HT, Sweatt JD, Zoghbi HY, Matzuk MM. Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation.
J Neurosci. 1998 Jul 15;18(14):5508-16. 
9651231 
Roberson ED, Sweatt JD. Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation.
J Biol Chem. 1996 Nov 29;271(48):30436-41. 
8940008 
Roberson ED, Halabisky B, Yoo JW, Yao Y, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GY, Palop JJ, Noebels JL, and Mucke L. (2011). Amyloid-beta/Fyn–induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease.
J. Neurosci., 31:700–711. 
21228179 
Rabinovici GD and Roberson ED. (2010). Beyond diagnosis: What biomarkers are teaching us about the “bio”logy of Alzheimer disease.
Ann. Neurol. 67:283–285. 
20373338 
Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L. Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.
J Neurosci. 2008 May 7;28(19):5007-17. 
18463254 
Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L. Abnormal social behaviors in mice lacking Fgf17.
Genes Brain Behav. 2008 Apr;7(3):344-54. 
17908176 
Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Neuron. 2007 Sep 6;55(5):697-711. 
17785178 
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Science. 2007 May 4;316(5825):750-4. 
17478722  
Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer's disease.
Science. 2006 Nov 3;314(5800):781-4. 
17082448 
Roberson ED. Frontotemporal dementia.
Curr Neurol Neurosci Rep. 2006 Nov;6(6):481-9. 
17074283  
Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
Neuron. 2006 Sep 21;51(6):703-14. 
16982417  
Roberson ED, Hesse JH, Rose KD, Slama H, Johnson JK, Yaffe K, Forman MS, Miller CA, Trojanowski JQ, Kramer JH, Miller BL. Frontotemporal dementia progresses to death faster than Alzheimer disease.
Neurology. 2005 Sep 13;65(5):719-25. 
16157905 
Roberson ED, Sweatt JD. A biochemical blueprint for long-term memory.
Learn Mem. 1999 Jul-Aug;6(4):381-8. 
10509708 
Roberson ED, English JD, Sweatt JD. A biochemist's view of long-term potentiation.
Learn Mem. 1996 Jul-Aug;3(1):1-24. 
10456072 
Roberson ED, English JD, Adams JP, Selcher JC, Kondratick C, Sweatt JD. The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus.
J Neurosci. 1999 Jun 1;19(11):4337-48. 
10341237 

Keywords
Neurodegeneration, Alzheimer's disease, frontotemporal dementia, tau, progranulin, excitability, signaling, plasticity, behavior