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Faculty Detail    
Name RAKESH PRAVINCHANDRA PATEL
 
Campus Address BMR2 532 Zip 2186
Phone  205-975-9225
E-mail  rakeshpatel@uabmc.edu
Other websites
     

Education
Undergraduate  University of Essex    1993  BSc. Hons 
Graduate  University of Essex    1996  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Anesthesiology   Anesthesiology Chair Office Associate Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Professor
Secondary  Surgery   Surgery - Gen Surg Trauma Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Ctr for Healthy Aging  Comprehensive Ctr for Healthy Aging Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Medicine  Comprehensive Diabetes Ctr (Org Ret) Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor
Center  Medicine  Ctr Cardiovasc Bio (Org Ret) Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr Patel graduated from the University of Essex, UK, where he also obtained his Ph.D in 1996. He then joined the Department of Pathology, University of Alabama at Birmingham (UAB) as a post-doctoral fellow, where he is currently Professor and Director of the UAB Center for Free Radical Biology. Dr Patel’s research centers on understanding the mechanisms that regulate acute and chronic inflammation with a goal of using these insights to develop and test therapeutics targeted to prevent or limit inflammatory injury. Current areas of research include i) investigating how heme proteins interface with reactive oxygen and nitrogen species (including nitric oxide and nitrite) to modulate transfusion toxicity, acute lung injury and ischemia reperfusion injury and ii) understanding how post-translational regulation of protein by N-glycans regulate endothelial cell reactivity and monocyte adhesion in the context of atherosclerosis.

Society Memberships
Organization Name Position Held Org Link
American Physiological Society     
American Society of Biochemistry and Molecular Biology     
Biochemical Society     
International Society for Free Radical Research     
Society for Free Radical Biology and Medicine     
Society for Glycobiology     

Research/Clinical Interest
Title
Modulation of Inflammation by Reactive Species and N-glycans
Description
We incorporate basic science and translational studies in pursuit of our research interests which are to understand redox related mechanisms regulating inflammation in various pathogenic states and how these are integrated to environmental stresses. We have two primary areas of focus i) understanding the molecular basis of nitric oxide and nitrite interactions with different organs and red blood cells and how these impact upon biological processes associated with blood flow regulation and pulmonary function during hypoxia, inflammation (associated with Sepsis, trauma, transfusion, transplantation or in response to inhaled (environmental) irritants) and ii) understanding how post-translational modification of proteins by carbohydrates control endothelial cell function and immune cell trafficking to regulate the inflammatory responses. We employ an integrative approach utilizing biochemical, molecular, cell culture and pre-clinical models to develop and test hypotheses and use the insights gained from studies design and conduct translational / clinical studies to test promising therapeutics.

Selected Publications 
Publication PUBMEDID
T. Graham, D. Peavey, T. Gray, R. Patel, H. Wang, JF. Pittet, J. Kerby, M. Marques (2017) Assuring Hospital Supply of Fresh Red Blood Cells for Critically Ill Patients. Transfusion. In Press DOI 10.1111/trf.14058  28425604 
K Ahmed, A Nichols, J Honavar, MT Dransfield, S Matalon, RP Patel (2017) Measuring nitrate reductase activity from human and rodent tongues Nitric oxide Jun 1;66:62-70  28390999 
Joo-Yeun Oh, Jennifer Hamm, Xin Xu, Kristopher Genschmer, Ming Zhong, Jeffrey Lebensburger, Marisa B. Marques, Jeffrey D. Kerby, Jean-Francois-Pittet, Amit Gaggar, Rakesh P. Patel (2016). Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices Redox Biol. 167-177. doi: 10.1016/j.redox.2016.08.003. PMCID: PMC5007433  5007433 
David A. Ford, Jaideep Honavar, Carolyn J. Albert, Mark A Duerr, Joo Yeun Oh, Stephen Doran, Sadis Matalon, Rakesh P. Patel (2016) Formation of chlorinated lipids post-chlorine gas exposure. J. Lip Research 57(8): 1529-40 PMCID:PMC4959868  4959868 
Yadav AK, Doran SF, Samal AA, Sharma R, Vedagiri K, Postlethwait EM, Squadrito GL, Fanucchi MV, Roberts LJ 2nd, Patel RP*, Matalon S* (2010) Mitigation of Chlorine Gas Lung Injury in rats by post exposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L362-9.*Co-senior authors   
Weinberg JA, MacLennan PA, Vandromme-Cusick MJ, Angotti JM, Magnotti LJ, Kerby JD, Rue LW III, Barnum SR, Patel RP (2012). Microvascular response to red blood cell transfusion in trauma patients. Shock 37:276-281   
C. Rodriguez, D. Vitturi, J He, M Vandromme, A Brandon, A Hutchings, LW Rue III, JD Kerby, RP Patel (2009) Sodium nitrite therapy attenuates hypertensive effects of HBOC-201 via a nitrite-reductase activity. Biochem J 422(3), 423-432   150230 
Cantu-Medellin N, Vitturi DA, Rodriguez C, Murphy S, Dorman S, Shiva S, Zhou Y, Jia Y, Palmer AF, Patel RP (2011). Effects of T-state and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling. Nitric Oxide: Biology and Chemistry. In Press  2396555 
D. Vitturi, X Teng, JC Toledo, S Matalon, JR Lancaster Jr, RP Patel (2009) Effects of Hemoglobin Fractional Saturation on Nitrite transport in Red Blood Cells: Evidence for Hypoxic Regulation of Nitrite Export. Am J Physiol In Press  2685350 
Jack H Crawford, James Huang, T. Scott Isbell, Sruti Shiva, Balu K Chacko, Alan Schechter, Victor M Darley-Usmar, Jeffrey D Kerby, John D Lang Jr, David Krauss, Chien Ho, Mark T Gladwin, Rakesh P Patel (2006) Hypoxia, Red Blood Cells and Nitrite Regulate NO-dependent Hypoxic Vasodilatation. Blood 107, 566-574  16195332 
Chacko BK, Scott DW, Chandler RT, Patel RP (2011). Endothelial surface N-glycans mediate leukocyte adhesion and are targets for the anti-inflammatory effects of PPAR ligands. J Biol. Chem. 286(44):38738-47  17237310 
John D Lang Jr, Xinjun Teng, Phillip Chumley, Jack H Crawford, T. Scott Isbell, Balu K Chacko, Yuliang Liu, Nirag Jhala, D. Ralph Crowe, Alvin B Smith, Richard C Cross, Luc Frenette, Mike Fallon , Eric E Kelley, Diana W Wilhite, Cheryl R Hall, Grier P Page, J Steven Bynon, Devin E Eckhoff and Rakesh P. Patel (2007) Preemptive Administration of Inhaled Nitric Oxide Accelerates Restoration of Liver Function in Adults Following Orthotopic Liver Transplantation. J Clin Inv. 4;117(9):2583-2591   17717604 
Kelpke SS, Chen B, Bradley KM, Teng X, Chumley P, Moore B, Head H, Viera L, Thompson JA, Crossman DK, Bray MS, Eckhoff DE, Agarwal A, Patel RP (2012). Sodium nitrite therapy protects against brain death induced kidney injury and improves post-transplantation function. Kidney International. 82(3):304-13  17947960 
Bennavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. 2007. 104; 17977-82
 
17951430 
Y Oh, R Stapley, V Harper, M Marques, RP Patel (2015) Predicting storage-dependent damage to Red Blood Cells using nitrite oxidation kinetics, Peroxiredoxin-2 oxidation and hemoglobin / free heme measurements. Transfusion 12; 2967-78 PMCID: PMC4715702  4715702 
T. Scott Isbell, Chiao-Wang Sun, Li-Chen Wu, Xinjun Teng, Dario A. Vitturi, Billy G Branch, Christopher G Kevi, Namasivayam Ambalavanan Lisa Schwiebert, Jinxiang Ren, Kevin M. Pawlik, Matthew B. Renfrow, Rakesh P. Patel*, Tim M. Townes*. (2008) Role of SNO-Hemoglobin in Normal Development and Physiology. Nature Medicine 14(7); 773
* Co-senior author
 
18516054 
Christopher G Kevil and Rakesh P Patel (2010) S-nitrosothiol biology and Therapeutic potential in metabolic disease. Current Opinion in Investigational Drugs. 10: 1127-34   20872315 
166. JA Weinberg and RP Patel (2016) Red Blood cell transfusion and its effect on microvascular dysfunction shock states. Best Practice and Research Clinical Anaesthesiology 30, 491-498


 
 
Greenway FL, Predmore BL, Flanagan DR, Giordano T, Qiu Y, Brandon A, Lefer DJ, Patel RP, Kevil CG.(2012)Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.Diabetes Technol Ther. 2012 Jul;14(7):552-60



 
22468627 
Owusu BY, Stapley R, Patel RP.(2012)Nitric oxide formation versus scavenging: the red blood cell balancing act.
J. Physiol. 590(Pt20):4993-5000


 
22687616 
Stapley R, Owusu BY, Brandon A, Cusick M, Rodriguez C, Marques MB, Kerby JD, Barnum SR, Weinberg JA, Lancaster JR Jr, Patel RP. (2012) Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity.Biochem J. 446(3);499-508



 
22720637 
Scott DW, Chen J, Chacko BK, Traylor JG Jr, Orr AW, Patel RP.(2012). Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis. ATVB 32(8) Epub Ahead of print



 
22723438 
Samal AA, Honavar J, Brandon A, Bradley KM, Doran S, Liu Y, Dunaway C, Steele C, Postlethwait EM, Squadrito GL, Fanucchi MV, Matalon S, Patel RP.(2012) Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Rad Biol Med 53(7):1431-9
 
22917977 
El-Ferzli GT, Dreher M, Patel RP, Ambalavanan N.(2012) ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure. PLos One 7(9)



 
22984626 
Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Wyss JM, Townes T, Patel RP (2012) Free Rad Biol Med Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. [Epub ahead of print]

 
23159546 
Shuai Yuan, Rakesh P Patel*, Christopher G Kevil* (2014) Working with nitric oxide and hydrogen sulfide in biological systems AJP Lung Cell Mol Physiol (2015); 308: L403
*Co-senior authors
 
25550314  
Jaideep Honavar, Stephen Doran, Joo Yeon Oh, Chad Steele, Sadis Matalon, Rakesh P. Patel (2014) Nitrite therapy improves post-chlorine gas exposure survival. AJP Lung Cell Mol Physiol 307:L888 PMCID: PMC4254962  PMCID: PMC4254962 
R Stapley, C Rodriguez, JY Oh, A Brandon, BM Wagener, MB Marques, JA Weinberg, JD Kerby, JF Pittet, RP Patel (2015) RBC Washing, nitrite therapy, and anti-heme therapies prevent stored RBC toxicity after trauma-hemorrhage. Free Rad Biol. Med. 85:207-218 PMCID: PMC4508223  4508223 
Victoria Harper, Joo-Yeun Oh, Ryan Stapley Marisa Marques, Landon Wilson, Stephen Barnes, Chiao-Wang Sun, Tim Townes, Rakesh P. Patel (2015). Peroxiredoxin-2 cycling is inhibited during erythrocyte storage. Antioxidant Redox Signaling 22: 294  25264713  
John D Lang Jr, Alvin B Smith, Angela Brandon, Kelley M Bradley, Yuliang Liu,D. Ralph Crowe, Nirag Jhala, Richard C Cross, Luc Frenette, Kenneth Martay, Youri Vater1, Alexander Vitin, Gregory Dembo, Derek DuBay, J Steven Bynon, Jeff M. Szychowski, Jorge Reyes, Jeffrey Halldorson, Stephen Rayhill, Andre Dick, Ramasamy Bakthavatsalam, Jo Ann Broeckel-Elrod1, Laura Sisson-Roberts, Terry Jordan, Lucinda Chen, Arunotai Siriussawakul, Devin E Eckhoff and Rakesh P. Patel (2014) Inhaled Nitric Oxide Administered Preemptively Improves Allograft Function and Decreases Post-operative Complications in Human Liver Transplantation PLOS One 9, e86053   24533048 
Jaideep Honavar, Eddie Bradley, Kelley Bradley, Joo Yeun Oh, Matthew O Vallejo, Eric E. Kelley, Nadiezhda Cantu-Medellin, Stephen Doran, Louis J. Dell’italia, Sadis Matalon, Rakesh P. Patel (2014) Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature. Toxicology 321: 96  24769334  
Cornelia S Hahn, David W. Scott, Xin Xu, Mojtaba Abdulroda, Gregory A. Payne, J. Michael Wells, Liliana Viera, Colleen J. Winstead, Patricia L. Jackson, J. Edwin Blalock, Rakesh P. Patel*, Amit Gaggar (2015) The Matrikine N-α-PGP Couples Extracelllar Matrix Fragmentation to Endothelial Permeability. Science Advances In Press
*Co-Senior Author
 
 

Keywords
vascular, hemoglobin, red cells, Inflammation, isoflavones, Nitric oxide, nitrite, N-glycan