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Faculty Detail    
Campus Address SC 7TH Zip 0017
Phone  205-975-0310
Other websites

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Behavioral Neurobiology Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 

Biographical Sketch 
1993 - B.A., Biology, (minor: Economics), New York University
1998 - M.S, Neuroscience, University of Pittsburgh
1999 - Ph.D., Neuroscience, University of Pittsburgh
2002 - M.D., University of Pittsburgh
2003-2008 - Post-doctoral Research Fellow, Molecular and Behavioral Neuroscience Institute, University of Michigan
2008-2010 - Research Investigator, Molecular and Behavioral Neuroscience Institute, University of Michigan
2011-now - Assistant Professor, Department of Psychiatry and Behavioral Neurobiology, secondary appointment in the Department of Neurobiology, member of the Comprehensive Neuroscience Center, University of Alabama at Birmingham

Society Memberships
Organization Name Position Held Org Link
American College of Neuropsychopharmacology  Associate Member 
American Physiological Society 
Society for Neuroscience 

Research/Clinical Interest
Physical Symptoms of Depression
In addition to low mood, trouble with concentration, and low motivation, depression is characterized by prominent physical symptoms, including fatigue, sleep disturbances, appetite changes, and altered blood pressure and heart rate. These physical symptoms contribute to high levels of medical comorbidity between depression and illnesses like diabetes and heart disease. My work examines the organization of brain circuits that regulate physical responses to stress, including cardiovascular responses (i.e. changes in blood pressure and heart rate) and control of movement. These studies are conducted in animal models of depression, and I am particularly interested in how re-wiring of such circuits in response to changes in the environment can contribute to, or alleviate, physical manifestations of depression. Parallel studies are also conducted in brain tissue collected from depressed individuals after their death. This work is focused on defining gene expression alterations in brain regions that control cardiovascular function and movement. Together these studies will improve our understanding of the neurobiology of stress-elicited adaptations, and how such systems are disrupted in mood disorders.

Selected Publications 
Publication PUBMEDID
Nam, H and Kerman, I. A. Distribution of catecholaminergic presympathetic-premotor neurons in the rat lower brainstem. Neuroscience. In Press.  26946268 
Rana, S., Nam H., Glover M. E., Akil H., Watson S. J., Clinton S. M., Kerman I. A. Protective effects of chronic mild stress during adolescence in the low novelty responder rat. Stress. In Press.  26473581 
Cohen J. L., Glover M. E., Pugh P. C., Fant A. D., Simmons R. K., Akil H., Kerman I. A., Clinton S. M. Maternal style selectively shapes amygdalar development and social behavior in rats genetically prone to high anxiety. Developmental Neuroscience 37:203-214, 2015.  25791846 
Rana S., Pugh P. C., Jackson N., Clinton S. M., Kerman I. A. Inborn stress reactivity shapes adult behavioral consequences of early-life maternal separation stress. Neuroscience Letters 584:146-150, 2015  25451726 
Nam, H., Clinton, S. M., Jackson, N. L., Kerman, I. A. Learned helplessness and social avoidance in the Wistar-Kyoto rat. Frontiers in Behavioral Neuroscience 8:109, 2014.  24744709 
Shah, N.S., Pugh, P. C., Nam, H., Rosenthal, D.T., van Wijk, D., Gaszner, B., Kozicz, T., Kerman, I. A. A subset of presympathetic-premotor neurons within the centrally projecting Edinger-Westphal nucleus expresses urocortin-1. Journal of Chemical Neuroanatomy 52:25-35, 2013.   23707488 
Kerman, I. A. New insights into BDNF signaling: relevance to major depression and antidepressant action. American Journal of Psychiatry 169:1137-1140, 2012.  23128919 
Kerman, I. A.*, Bernard, R*, Bunney, W. E., Jones, E. G., Schatzberg, A. F., Myers, R. M., Barchas, J. D., Akil, H., Watson, S. J. , Thompson, R. C. Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder. Frontiers in Neuroscience 6:135, 2012. * - equal contributors  23087602 
Kerman, I. A.*, Clinton, S. M.*, Simpson, D. N., Bedrosian T. A., Bernard, R., Akil, H., Watson, S. J. Inborn differences in environmental reactivity predict divergent diurnal behavioral, endocrine, and gene expression rhythms. Psychoneuroendocrinology. 37:256-269, 2012. * - equal contributors  21775066 
Clinton, S. M.*, Kerman, I. A.*, Orr, H. R., Bedrosian T. A., Abraham, A. D., Simpson, D. N., Watson, S. J., Akil, H. Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter. Brain Research 1422:20-31, 2011. * - equal contributors  21974861 
Kerman, I. A.*, Clinton, S. M.*, Bedrosian T. A., Abraham, A. D., Rosenthal, D. T., Akil, H., Watson, S. J. High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups. Brain Research 1419:34-45, 2011. * - equal contributors  21925645 
Stedenfeld, K. A., Clinton, S. M., Kerman, I. A., Akil, H., Watson, S. J., Sved, A. F. Novelty-seeking behavior predicts vulnerability in a rodent model of depression. Physiology and Behavior 103:210-216, 2011.   21303678 
Bernard, R*., Kerman, I. A.*, Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., Watson, S. J. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Molecular Psychiatry 16:634-646, 2011. * - equal contributors
Zhang, Y., Kerman, I. A., Laque, A., Nguyen, P., Faouzi, M., Louis, G. W., Jones, J. C., Rhodes, C., Münzberg, H. Leptin receptor expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. Journal of Neuroscience 31:1873-1884, 2011  21289197 
Krolewski, D. M., Medina, A., Kerman, I. A., Bernard, R., Burke, S., Thompson, R. C., Bunney, Jr., W. E., Schatzberg, A. F., Barchas, J., Myers, R. M., Akil, H., Jones, E. G., Watson, S. J. Expression patterns of corticotropin-releasing factor, arginine vasopressin, histidine decarboxylase, melanin-concentrating hormone, and orexin genes in the human hypothalamus. Journal of Comparative Neurology 518:4591-4611, 2010.   20886624 
Gonsalvez, D. G., Kerman, I. A., McAllen, R. M., Anderson, C. R. Chemical coding for cardiovascular sympathetic preganglionic neurons in rats. Journal of Neuroscience 30:1178-1191, 2010.   20810898  
Rice, C. D., Lois, J. H., Kerman, I. A., Yates, B. J. Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat. Brain Research 1279:71-81, 2009.   19433074 
Kerman, I. A. Organization of brain somatomotor-sympathetic circuits. Experimental Brain Research 187:1-16, 2008.   18369609 
Kerman, I. A., Bernard, R., Rosenthal, D., Beals, J., Akil, H, Watson, S. J. Distinct populations of presympathetic-premotor neurons express orexin or melanin-concentrating hormone in the rat lateral hypothalamus. Journal of Comparative Neurology 505:586-601, 2007  17924541 
Kerman, I. A., Shabrang, C., Taylor, L., Akil, H., Watson, S. J. Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem. Journal of Comparative Neurology 499:882-896, 2006.   17072838 
Kerman, I. A., Akil, H., Watson, S. J. Rostral elements of sympatho-motor circuitry: a virally-mediated transsynaptic tracing study. Journal of Neuroscience 26:3423-3433, 2006.   16571749 
Kerman, I. A., Enquist, L. W., Watson, S. J. Yates, B. J. Brainstem substrates of sympatho-motor circuitry identified using transsynaptic tracing with pseudorabies virus recombinants. Journal of Neuroscience 23:4657-4666, 2003.   12805305 

rat, gene expression, circuits, physiology, neuronatomy, tract-tracing, virus, cardiovascular, obesity, metabolism, fatigue