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Faculty Detail    
Name VICTOR M DARLEY-USMAR
Endowed Professor of Mitochondrial Medicine and Pathology
Associate Dean for Research School of Medicine
Director, Mitochondrial Medicine Laboratory
 
Campus Address BMR2 508 Zip 2186
Phone  205-975-9686
E-mail  vdarleyusmar@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Anesthesiology   Anesthesiology Chair Office Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Professor
Secondary  Neurobiology  Neurobiology Professor
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Medicine  Ctr Cardiovasc Bio (Org Ret) Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Hughes Med-Grad Fellowship Program 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Darley-Usmar is the UAB Endowed Professor in Mitochondrial Medicine and Pathology. He serves as Associate Dean for Research for the School of Medicine at UAB. His research program focuses on redox cell signaling and molecular bioenergetics in the pathogenesis of human disease. He received his Ph.D. training from Dr. M.T. Wilson at the University of Essex which was to define the structure and function of cytochrome c oxidase. This involved defining whether the monomer or dimer of the enzyme was active and applying the then new techniques of SDS-polyacrylamide gel electrophoresis to membrane proteins. He continued to pursue his interest in mitochondrial proteins with Dr. R. A. Capaldi at the University of Oregon and was one of the first to use Western Blotting to understand the molecular pathology of a mitochondrial myopathy. On returning to the UK after two years as an Assistant Professor in Japan he first became interested in the area of nitric oxide research in industry as a Research Scientist at Wellcome Research Laboratories. Over a ten year period there he worked on the interactions of nitric oxide with reactive oxygen species and mitochondria. Working with Salvador Moncada and Tony Schapira (Royal Free Hospital) he was one of the first to discover that nitric oxide can interact reversibly with cytochrome c oxidase and so control respiration. He left the UK in 1995 to join the Free Radical group and Department of Pathology at UAB led by Bruce Freeman. Currently he is developing novel methods to assess the measurement of bioenergetic health in human populations.

Society Memberships
Organization Name Position Held Org Link
Society For Free Radical Biology and Medicine  former President/ member   



Research/Clinical Interest
Title
Mitochondrial Health; Bench to Bedside
Description
The most serious diseases that effect developed nations such as atherosclerosis, neurodegeneration and diabetes are known to involve mitochondrial dysfunction. The challenge is to translate the findings in basic research in mitochondrial function and the pathology of disease to the clinic. To achieve this we are developing new methods to assess bioenergetic dysfunction in human disease and determine its diagnostic potential. The approach we are taking is to develop new methods for defining bioenergetic health in human populations using the cellular mitochondrial function of leukocytes and platelets isolated from human blood.

Selected Publications 
Publication PUBMEDID
Chacko, B.K. Kramer, P.A.,Ravi, S, Benavides, G.A., Mitchell, T., Dranka, B.P., Ferrick, D., Singal, A.K., Ballinger, S.W., Bailey, S.M., Hardy, R.W., Jianhua Zhang, J, Zhi, D., and Darley-Usmar, V.M. (2014) The Bioenergetic Health Index: A New Concept in Mitochondrial Translational Research. Clinical Science 127, (367–373).   PMCID: PMC4202728 
Ravi S, Chacko B, Sawada H, Kramer PA, Johnson MS, Benavides GA, O'Donnell V, Marques MB, Darley-Usmar VM. (2015) Metabolic plasticity in resting and thrombin activated platelets.
PLoS One.;10(4):e0123597
 
 
Hill B, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological Chemistry. 393: 1485–1512, 2012.   PMCID: PMC3594552 
Dodson M, Darley-Usmar VM, Zhang J (2013) Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radical Biology and Medicine 63:207-221   PMCID:PMC3729625 
Wende AR, Young ME, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM. (2016) Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radic Biol Med. (16)30270-2.  27242268 
Slatter, D.A., Aldrovandi, M., O’Connor, A., Allen, S., Brasher, C., Murphy, R.C., Mecklemann, S., Ravi, S., Darley-Usmar V., and O’Donnell. V.B. (2016). Mapping the human platelet lipidome reveals a wealth of novel species, and reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics. Cell Metabolism 23, 930-944.  27133131  
Kramer PA, Chacko BK, George DJ, Zhi D, Wei CC, Dell'Italia LJ, Melby SJ, George JF, Darley-Usmar VM. (2015) Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients. Biosci Rep 35(4).  26181371 
Kramer, P.A., Prichard, L, Chacko, B.,Ravi, S.,Overton, E.T.,Heath, S.L., Darley-Usmar V (2015) Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophils. Clinical Science 129:489-504.  25951298 

Keywords
mitochondria, nitric oxide, reactive oxygen species, bioenergetic dysfunciton, translational research