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Faculty Detail    
Name SURESH KUMAR VERMA
Associate Professor
 
Campus Address ZRB 302 Zip 0007
Phone  205-975-8833
E-mail  sverma@uabmc.edu
Other websites http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1jo4fxRipaKcnmtPDdHE2XKkh/?sort=date&direction=ascending
https://scholar.google.com/citations?user=Ymtlz_gAAAAJ&hl=en
     

Education
Undergraduate  RML Avadh University Faizabad, UP, India    2000  MS 
Graduate  Postgraduate Institute of Medical Education and Research, Chandigarh, India    2007  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Associate Professor
Center  Comprehensive Cardiovascular Ctr  Comprehensive Cardiovascular Ctr Associate Professor

Biographical Sketch 
Dr. Verma is an Associate Professor in Division of Cardiovascular Disease and in Comprehensive Cardiovascular Center (CCVC) here in Department of Medicine, UAB. He obtained his MS and PhD from India both in Biochemistry. Dr. Verma’s Strong interest in basic and translational research motivate him to come USA and start his postdoctoral training first with Prof. David E. Dostal at Texas A&M University Texas followed by Prof. Raj Kishore at Northwestern University, Chicago, Illinois. Before coming to UAB, Division of Cardiovascular Disease in 2018, Dr. Verma served as Assistant Professor first in Feinberg Cardiovascular Research Institute, Northwestern University Chicago and later in Center for Translational Medicine, Temple University Philadelphia. Dr. Verma published over 40 peer-reviewed articles in high impact journal including Circulation, Circulation Research, JACC, JMCC etc. He actively involves with scientific services such as editor/reviewer for many journals and grant agencies (like AHA). Dr. Verma is recipient/finalist of multiple honor and awards including AHA prestigious Outstanding Young Investigator Award (2013), New Investigator travel Award (2011) etc. The primary mission of Dr. Verma’s research is to identify and test novel therapeutic targets to prevent or delay development and progress of heart failure.

Society Memberships
Organization Name Position Held Org Link
American Heart Association (AHA-BCVS)  Member  http://www.heart.org/HEARTORG/ 
International Society of Heart Research (ISHR)  Memeber  https://www.ishr.ch/ 
Society of Neuroscience India  Life Member  https://www.sfn.org/ 



Research/Clinical Interest
Title
Novel Pathways for Cardiac Fibrosis, Stem Cells in Cardiac Repair and Regeneration, Metabolic Regulation of Cardiac Cell death
Description
The overall focus of my research is to understand the molecular mechanisms of pathological remodeling and heart failure. Heart disease involves complex signaling pathways associated with inflammation, cardiomyocytes death and the replacement of death cells with fibrous scar. Indeed, metabolic condition, such as diabetes, aggravates inflammatory responses and fibrotic remodeling during both hypertrophic and ischemic heart failure. The current focus of my laboratory involves following broad and interrelating research areas: 1. Determine whether bone marrow progenitor cell and/or resident endothelial cells are involved in pathological fibrosis in chronic pressure overloaded myocardium. 2. Identify the novel molecular mediators for cardiac cells death in the infarcted diabetic heart. Investigate the cross-talk of macrophages using exosomes with cardiomyocytes on this process. 3. Determine the role of inflammation on autophagic cell death of heart cells. My laboratory uses state of the art techniques and strategies such as genetically manipulated animal models, RNA interference, microRNA strategies, recombinant DNA technologies, Electron/Fluorescent microscopy etc to dissect the mechanisms proposed above. We are always looking for motivated, creative people to join the lab. Please send your CV, cover letter and contact information of three references to me: sverma@uabmc.edu

Selected Publications 
Publication PUBMEDID
Verma SK. Glycogen synthase kinase 3b helps heart to beat better in obese patients. International Journal cardiology (2018) 259:166-167.   29579595 
Verma SK., Garikipati VNS., Krishnamurthy PK., Schumacher SM., Grisanti LA., Cimini M., Cheng Z., Khan M., Yue Y., Benedict C., Truongcao MM., Rabinowitz JE., Goukassian DA., Tilley D., Koch WJ., Kishore R. IL-10 inhibits bone marrow fibroblast progenitor cells mediated cardiac fibrosis in pressure-overloaded myocardium. Circulation (2017) 136:940-953.   28667100 
Verma SK., Girikipati VNS., Kishore R. Mitochondrial dysfunction and its impact on diabetic heart. BBA-molecular basis of diseases (2017) 1863: 1098-1105.   27593695 
Kishore R., Krishnamurthy PK., Garikipati V.N.S., Abramova T., Nickoloff E., Benedict C., Khan M., Johnson J., Gumpert AM, Koch W.J. and Verma S.K. IL-10 inhibits pressure overload-induced pathological autophagy. Journal of Molecular and Cellular Cardiology (2015) 89:203-213.  26549357 
Verma SK, Krishnamurthy PK, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh A and Kishore R. IL10 attenuates pressure overload induced hypertrophic remodeling and improves heart function via STAT3 dependent inhibition of NFkB. Circulation. 2012; 126(4): 418-429.  22705886 
Kishore R and Verma SK. JAK-STAT signaling in cardiovascular diseases. The JAK-STAT. 2012; 1 (2):119-125  24058760 
Verma, SK, Lal, H, Golden, HB, Smith, M, Guleria, RS, Foster, DM, Lu, G and Dostal, DE. Differential Roles of Rac1 and RhoA in regulating mechanical stretch-induced angiotensinogen gene expression in cardiac fibroblasts. Cardiovascular Research 2011; 90(1): 88-96.  21131638 

Keywords
Myocardial inflammation, Cardiac fibrosis, miRNAs, Exosome, Cell signaling, Cardiac cell death, mRNA epigenetic, Paracrine signaling and Hypertrophic heart failure.