Integrative Biomedical Sciences |
Medical Scientist Training Program |
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Organization Name |
Position Held |
Org Link |
American Association for Pharmacology and Experimental Therapeuti |
member |
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American Association for the Advancement of Science |
member |
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American Association of Cancer Research |
member |
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American Society of Biochemistry and Molecular Biology |
member |
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American Society of Tropical Medicine and Hygiene |
member |
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International Society for Nucleosides, Nucleotides and Nucleic Acids |
member |
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Publication |
PUBMEDID |
OH T, el Kouni MH.Distinct Substrate Specificity and Physicochemical Characterization of Native Human Hepatic Thymidine Phosphorylase. PLoS ONE 13: e0202826. (2018) |
30138393 |
el Kouni MH. Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets. Comp Biochem Physiol Part B 213: 55–80 (2017) |
28735972 |
Naguib FN, Rais RH, Al Safarjalani ON, el Kouni MH. Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine. Comp Biochem Physiol B Biochem Mol Biol 188:63-69 (2015) |
26112826 |
Naguib FNM and el Kouni MH. Nucleoside Kinases in Adult Schistosoma mansoni: Phosphorylation of Pyrimidine Nucleosides. Mol Biochem Parasitol 194: 53-55 (2014) |
24786512 |
Savarese TM, el Kouni MH. Isolation and Substrate Specificity of an Adenine Nucleoside Phosphorylase from Adult Schistosoma mansoni Mol Biochem Parasitol 194: 44-47 (2014) |
24794680 |
Van Duyne R, Guendel I, Jaworski E, Sampey G, Klase Z, Chen H, Zeng C, Kovalskyy D, el Kouni MH, Lepene B, Patanarut A, Nekhai S, Price DH, Kashanchi F. Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription. J Molec Biol 425:812-29 (2013) |
23247501 |
Al Safarjalani ON, Rais R, Naguib FNM and el Kouni MH. Potent Combination Therapy for Human Breast Tumors with High Doses of 5-Fluorouracil: Remission and Lack of Host-Toxicity.Cancer Chemother Pharmacol 69:1449–1455 (2012) |
22373605 |
Al Safarjalani ON, Rais RH, Kim YA, Chu CK, Naguib FN, el Kouni MH. Carbocyclic 6-benzylthioinosine Analogues as Subversive Substrate of Toxoplasma gondii Adenosine Kinase: Biological Activities and Selective Toxicities. Biochem Pharmacol 80:955-963 (2010) |
20541538 |
Pulaa, WB, Dunn E. Garonnaa K, Watsona E, Hiranoc M, Pizzorno G, Schwartze EL, el Kouni MH,Wheeler-Jones CPD. Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-derived Deoxyribose-1-phosphate. J Arteriosclerosis, Thrombosis, Vascular12:2631-2638 (2010) |
20884872 |
Kim YA, Rawal RK, Yoo J, Sharon A, Jha AK, Chu CK, Rais RH, Al Safarjalani ON, Naguib FN,el Kouni MH.Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Bioorg Med Chem. 18:3403-3412.(2010) |
20456959 |
Choi JW, Shin CY, Choi MS, Yoon SY, Ryu JH, Lee JC, Kim WK, el Kouni MH, Ko KH. Uridine protects cortical neurons from glucose deprivation-induced death: Possible role of uridine phosphorylase. J Neurotrauma. 25:695–707 (2008) |
18457515 |
Guarcello V, Blanquicett C, Naguib FN, el Kouni MH..Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity. Cancer Chemother Pharmacol 62:85-96 (2008) |
17805539 |
Zhang Y, el Kouni MH, Ealick SE.Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase. Acta Crystallogr D Biol Crystallogr 63(Pt 2):126-34 (2007) |
17242506 |
el Kouni MH. Adenosine Metabolism in Toxoplasma gondii: Potential Targets for Chemotherapy. Curr Pharm Des 13: 581-597 (2007) |
17346176 |
Kim YA, Sharon A, Chu CK, Rais RH, Al Safarjalani ON, Naguib FN, el Kouni MH.Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.Biochem Pharmacol 73:1558-72(2007) |
17306769 |
Al Safarjalani ON, Rais R, Shi J, Schinazi RF, Naguib FN, el Kouni MH, Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor. Cancer Chemother Pharmacol 58:692-698 (2006) |
6528530 |
Zhang Y, el Kouni MH , Ealick SE.Crystal structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 Å resolution. Acta Cyst D61: 140-145 (2006) |
16421444 |
Al Safarjalani ON, Zhou, X-J, Rais RH, Shi J, Schinazi RF, Naguib FNM and el Kouni MH. 5-(Phenylthio)acyclouridine, a powerful enhancer of oral uridine bioavailability: Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens. Cancer Chemother Pharmacol 55:541-551 (2005) |
5729584 |
Weiming B, Settembre EC, el Kouni MH and Ealick SE. Aspects of Escherichia coli uridine phosphorylase inhibition by 5-substituted acyclouridines. Acta Cystalograph D 61:863-72(2005) |
5983408 |
Al Safarjalani ON, Zhou X-J, Rais RH, Shi J, Schinazi RF, Naguib FNM and el Kouni MH.5-(Phenylthio)acyclouridine, a Powerful Enhancer of Oral Uridine Bioavailability: Relevance to Chemotherapy with 5-fluorouracil and Other Uridine Rescue Regimens. Cancer Chemother. Pharmacol. 55: 541-551 (2005). |
15729584 |
Rais RH, Al Safarjalani ON, Yadav V, Guarcello V, Kirk M, Chu CK, Naguib FNM, and el Kouni MH. 6-Benzylthioinosine Analogues as Subversive Substrate of Toxoplasma gondii Adenosine Kinase: Activities and Selective Toxicities. Biochem Pharmacol 69: 1409-1419 (2005) |
15857605 |
Gupte A, Buolamwini JK,Yadav V, Chu CK, Naguib FNM and el Kouni MH.6-Benzylthioinosine Analogues Promising Antitoxoplasmic Agents as Inhibitors of the Mammalian Nucleoside Transporter ENT1 (es). Biochem Pharmacol 71:69-73(2005) |
16310172 |
el Kouni MH. Potential Chemotherapeutic Targets in the Purine Metabolism of Parasites. Pharmac Therapt 99: 283-309 (2003) |
12951162 |
Yadav V, Chu C K, Rais RH, Al Safarjalani ON, Guarcello V, Naguib FNM and el Kouni MH. Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma gondii Adenosine Kinase. J Med Chem 47: 1987-1996 (2004) |
15055998 |
Al Safarjalani ON, Naguib, FNM and el Kouni MH. Uptake of Nitrobenzylthioinosine and Purine â-L-Nucleosides by Intracellular Toxoplasma gondii. Antiviral Chem. Chemother 47:32347-3251(2003) |
15055998 |
el Kouni MH.Trends in the design of nucleoside analogues as anti-HIV drugs. Curr Pharm Des 8:581-93 (2002) |
11945160 |
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