Undergraduate |
Bharathidhasan University, Trichy, India |
|
1992 |
B.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1994 |
M.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1996 |
M.Phil. |
Graduate |
University of Madras, Chennai, India |
|
2001 |
Ph.D. |
|
Appointment Type |
Department |
Division |
Rank |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Associate Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Associate Professor |
Center |
Ctr for Exercise Medicine (Org Ret) |
Ctr for Exercise Medicine (Org Ret) |
Associate Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Associate Professor |
Secondary |
Dept of Biomedical Engineering |
Dept of Biomedical Engineering |
Assistant Professor |
|
Cellular and Molecular Biology Program |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Devarajan, A., Rajasekaran, N.S., Valburg, C., Ganapathy, E., Bindra, S. and Freije, W.A., 2019. Maternal perinatal calorie restriction temporally regulates the hepatic autophagy and redox status in male rat. Free Radical Biology and Medicine, 130, pp.592-600. |
30248445 |
Haglund, T.A., Rajasekaran, N.S., Smood, B., Giridharan, G.A., Hoopes, C.W., Holman, W.L., Mauchley, D.C., Prabhu, S.D., Pamboukian, S.V., Tallaj, J.A. and Rajapreyar, I.N., 2019. Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model. The Journal of Heart and Lung Transplantation, 38(4), pp.456-465. |
30503074 |
Berry, J.L., Zhu, W., Tang, Y.L., Krishnamurthy, P., Ge, Y., Cooke, J.P., Chen, Y., Garry, D.J., Yang, H.T., Rajasekaran, N.S. and Koch, W.J., 2019. Convergences of life sciences and engineering in understanding and treating heart failure. Circulation research, 124(1), pp.161-169. |
30605412 |
Goh, K.Y., He, L., Song, J., Jinno, M., Rogers, A.J., Sethu, P., Halade, G.V., Rajasekaran, N.S., Liu, X., Prabhu, S.D. and Darley-Usmar, V., 2019. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox biology, 21, p.101100. |
30641298 |
Kuster, D.W., Lynch IV, T.L., Barefield, D.Y., Sivaguru, M., Kuffel, G., Zilliox, M.J., Lee, K.H., Craig, R., Namakkal-Soorappan, R. and Sadayappan, S., 2019. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovascular research, 115(14), pp.1986-1997. |
31050699 |
Shanmugam, G., Challa, A.K., Litovsky, S.H., Devarajan, A., Wang, D., Jones, D.P., Darley-Usmar, V.M. and Rajasekaran, N.S., 2019. Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice. Redox biology, 27, p.101212. |
31155513 |
Shanmugam, G., Challa, A.K., Devarajan, A., Athmanathan, B., Litovsky, S.H., Krishnamurthy, P., Davidson, C.J. and Rajasekaran, N.S., 2019. Exercise mediated Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling. Frontiers in cardiovascular medicine, 6, p.68. |
31245386 |
Kannappan, R., Turner, J.F., Miller, J.M., Fan, C., Rushdi, A.G., Rajasekaran, N.S. and Zhang, J., 2019. Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell–Derived Cardiomyocytes for Myocardial Repair. Circulation, 140(6), pp.520-522. |
31381423 |
Kim, S., Song, J., Ernst, P., Latimer, M.N., Ha, C.M., Goh, K.Y., Ma, W., Rajasekaran, N.S., Zhang, J., Liu, X. and Prabhu, S.D., 2020. MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 318(3), pp.H682-H695. |
32004065 |
Pecha, P.P., Almishaal, A.A., Mathur, P.D., Hillas, E., Johnson, T., Price, M.S., Haller, T., Yang, J., Rajasekaran, N.S., Firpo, M.A. and Park, A.H., 2020. Role of Free Radical Formation in Murine Cytomegalovirus–Induced Hearing Loss. Otolaryngology–Head and Neck Surgery, 162(5), pp.709-717. |
32041493 |
Miller, J.M., Mardhekar, N.M., Pretorius, D., Krishnamurthy, P., Rajasekaran, N.S., Zhang, J. and Kannappan, R., 2020. DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes. American Journal of Physiology-Heart and Circulatory Physiology, 318(4), pp.H801-H815. |
32057252 |
Shanmugam, G., Wang, D., Gounder, S.S., Fernandes, J., Litovsky, S.H., Whitehead, K., Radhakrishnan, R.K., Franklin, S., Hoidal, J.R., Kensler, T.W. and Dell'Italia, L., 2020. Reductive stress causes pathological cardiac remodeling and diastolic dysfunction. Antioxidants & redox signaling, 32(18), pp.1293-1312. |
32064894 |
Rajasekaran, N.S., Shelar, S.B., Jones, D.P. and Hoidal, J.R., 2020. Reductive stress impairs myogenic differentiation. Redox biology, 34, p.101492. |
32361680 |
Rajasekaran, N.S., 2020. Reductive Stress: Neglected Science. Antioxidants & redox signaling. |
32375496 |
Murugesan, S., Saravanakumar, L., Powell, M.F., Kannappan, R. and Berkowitz, D.E., 2020. Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular disease. Placenta. |
33171429 |
Murugesan S, Saravanakumar L, Powell MF, Rajasekaran NS, Kannappan R, Berkowitz DE. Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular disease. Placenta. 2021 Jan 1;103:226-231. doi: 10.1016/j.placenta.2020.10.033. Epub 2020 Oct 28. PMID: 33171429; PMCID: PMC8278543. |
33171429 |
Narasimhan, K.K.S., Devarajan, A., Karan, G., Sundaram, S., Wang, Q., van Groen, T., Del Monte, F. and Rajasekaran, N.S., 2020. Reductive stress promotes protein aggregation and impairs neurogenesis. Redox biology, 37, p.101739. |
33242767 |
Kain V, Ingle KA, Rajasekaran NS, Halade GV. Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice. Theranostics. 2021 Jan 1;11(6):2742-2754. doi: 10.7150/thno.51183. PMID: 33456570; PMCID: PMC7806484. |
33456570 |
Klionsky DJ,...,Rajasekaran NS,...,Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751; PMCID: PMC7996087. |
33634751 |
Ravichandran G, Lakshmanan DK, Murugesan S, Elangovan A, Rajasekaran NS, Thilagar S. Attenuation of protein glycation by functional polyphenolics of dragon fruit (Hylocereus polyrhizus); an in vitro and in silico evaluation. Food Res Int. 2021 Feb;140:110081. doi: 10.1016/j.foodres.2020.110081. Epub 2020 Dec 29. PMID: 33648300. |
33648300 |
Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021 Jun;169:317-342. doi: 10.1016/j.freeradbiomed.2021.03.046. Epub 2021 Apr 25. PMID: 33910093; PMCID: PMC8285002. |
33910093 |
Quiles JM, Pepin ME, Sunny S, Shelar SB, Challa AK, Dalley B, Hoidal JR, Pogwizd SM, Wende AR, Rajasekaran NS. Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Sci Rep. 2021 Jun 7;11(1):11977. doi: 10.1038/s41598-021-90583-y. PMID: 34099738; PMCID: PMC8184797. |
34099738 |
Henderson J, Dubey PK, Patil M, Singh S, Dubey S, Namakkal Soorappan R, et al. microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice. Frontiers in Cardiovascular Medicine. 2021;8. |
34485421 |
Sunny S, Challa AK, Qiao A, Jyothidasan A, Krishnamurthy P, Ramamurthy MT, Crossman DK, Pogwizd S, Cinghu S, Rajasekaran NS. Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium. Cardiol Cardiovasc Med. 2021;5(5):454-470. doi: 10.26502/fccm.92920215. Epub 2021 Sep 7. PMID: 34497977; PMCID: PMC8423094. |
34497977 |
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