Graduate |
Indian Institute of Technology (Bombay/India) |
|
1998 |
Ph. D. |
|
Appointment Type |
Department |
Division |
Rank |
Secondary |
Surgery - General Surgery |
Surgery - Gen Surg Gastrointestinal Section |
Associate Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Nutrition Sciences Research |
Nutrition Obesity Res Ctr (NORC) |
Professor |
Center |
Biomatrix Eng Regen Med (BERM) Ctr |
Biomatrix Eng Regen Med (BERM) Ctr |
Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Professor |
|
Cancer Biology |
Cell, Molecular, & Developmental Biology |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Mitra A, Fillmore RA, Metge BJ, Rajesh M, Xi Y, King J, Ju J, Pannell L, Shevde LA, Samant RS. Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer. Breast Cancer Res. 2008;10(2):R22 |
18328103 |
Mitra A, Shevde LA, Samant RS. Multi-faceted role of HSP40 in cancer.Clin Exp Metastasis. 2009;26(6):559-67. |
19340594 |
Fillmore RA, Mitra A, Xi Y, Ju J, Scammell J, Shevde LA, Samant RS. Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth.Int J Cancer. 2009 Aug 1;125(3):556-64. |
19358268 |
Shevde LA, Metge BJ, Mitra A, Xi Y, Ju J, King JA, Samant RS Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontin.J Cell Mol Med. 2010 Jun;14(6B):1693-706. |
19538464 |
Das S, Harris LG, Metge BJ, Liu S, Riker AI, Samant RS, Shevde LA.The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.J Biol Chem. 2009 Aug 21;284(34):22888-97. |
19556240 |
Mitra A, Menezes ME, Shevde LA, Samant RS.DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.J Biol Chem. 2010 Aug 6;285(32):24686-94. |
20522561 |
Das S, Samant RS, Shevde LA.Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis.J Biol Chem. 2011 Mar 18;286(11):9612-22. |
21169638 |
Harris LG, Samant RS, Shevde LA.Hedgehog signaling: networking to nurture a promalignant tumor microenvironment.Mol Cancer Res. 2011 Sep;9(9):1165-74. |
21775419 |
Menezes ME, Devine DJ, Shevde LA, Samant RS Dickkopf1: a tumor suppressor or metastasis promoter? Int J Cancer. 2012 Apr 1;130(7):1477-83. |
21953410 |
Morrow KA, Das S, Metge BJ, Ye K, Mulekar MS, Tucker JA, Samant RS, Shevde LA.Loss of tumor suppressor Merlin in advanced breast cancer is due to post-translational regulation.J Biol Chem. 2011 Nov 18;286(46):40376-85. |
21965655 |
Harris LG, Pannell LK, Singh S, Samant RS, Shevde LA.Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.Oncogene. 2011 |
22056874 |
Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3beta to downregulate beta-catenin transcription target, osteopontin.Oncogene. 2012 |
22266849 |
Menezes ME, Mitra A, Shevde LA, Samant RS.DNAJB6 governs a novel regulatory loop determining Wnt/beta-catenin signalling activity.Biochem J. 2012 Jun 15;444(3):573-80. |
22455953 |
Andrews JF, Sykora LJ, Barik Letostak T, Menezes ME, Mitra A, Barik S, Shevde LA, Samant RS. Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.Exp Cell Res. 2012 Jun 10;318(10):1086-93. |
22504047 |
Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS. Micro-RNA-632 downregulates DNAJB6 in breast cancer.Lab Invest. 2012 |
22710984 |
Das S, Samant RS, Shevde LA.Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition.J Biol Chem. 2013 Apr 26;288(17):11824-33. |
23508962 |
Devine DJ, Rostas JW, Metge BJ, Das S, Mulekar MS, Tucker JA, Grizzle WE, Buchsbaum DJ, Shevde LA, Samant RS. Loss of N-Myc interactor promotes epithelial–mesenchymal transition by activation of TGF-β/SMAD signaling. Oncogene. 2013 Jun 17. doi: 10.1038/onc.2013.215 |
23770854 |
Rostas JW 3rd, Pruitt HC, Metge BJ, Mitra A, Bailey SK, Bae S, Singh KP, Devine DJ, Dyess DL, Richards WO, Tucker JA, Shevde LA, Samant RS. microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer. Mol Cancer. 2014 Aug 29;13(1):200. |
25174825 |
Metge BJ, Mitra A, Chen D, Shevde LA, Samant RS. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015 Jul 6;5:11995 |
26146406 |
Pruitt HC, Devine DJ, Samant RS. Roles of N-Myc and STAT Interactor in Cancer: From Initiation to Dissemination. Int J Cancer. 2016 doi: 10.1002/ijc.30043. |
26874464 |
Pruitt, H.C., Metge, B.J., Weeks, S.E., Chen, D., Wei, S., Kesterson, R.A., Shevde, L.A., Samant, R.S. (2018). Conditional knockout of N-Myc and STAT Interactor Disrupts Normal Mammary Development and Enhances Metastatic Ability of Mammary Tumors. Oncogene 37(12):1610-1623. |
29326438 |
Weeks SE, Metge BJ, Samant RS. (2019) The nucleolus: a central response hub for the stressors that drive cancer progression. Cell Mol Life Sci. 76(22):4511-4524 |
31338556 |
Metge BJ, Kammerud SC, Pruitt HC, Shevde LA, Samant RS. Hypoxia re-programs 2'-O-Me modifications on ribosomal RNA. iScience. 2020;24(1):102010. |
33490918 |
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