Undergraduate |
Fudan University, Shanghai, China |
|
1987 |
Bachelor of Science |
Graduate |
University of Vermont, Burlington, VT |
|
1994 |
Ph.D. in Zoology/Molecular Biology |
Fellowship |
Washington University School of Medicine, St. Louis, MO |
|
1999 |
Bone Biology |
|
Appointment Type |
Department |
Division |
Rank |
Center |
Biomatrix Eng Regen Med (BERM) Ctr |
Biomatrix Eng Regen Med (BERM) Ctr |
Professor |
Center |
Cell Adhesion & Matrix Research Center |
Cell Adhesion & Matrix Research Center |
Professor |
Center |
Center for Biophysical Sciences/Engineering |
Center for Biophysical Sciences/Engineering |
Professor |
Center |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Professor |
Center |
UAB Immunology Institute |
UAB Immunology Institute |
Professor |
|
Cancer Biology |
Immunology |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Lam J, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL (2000) Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest. 105(4):433-40. |
10683372 |
Feng X, Teitelbaum SL, Quiroz ME, Cheng SL, Lai CF, Avioli LV, Ross FP (2000) Sp1/Sp3 and PU.1 differentially regulate beta(5) integrin gene expression in macrophages and osteoblasts. J Biol Chem. 275(12):8331-40. |
10722663 |
Cheng SL, Lai CF, Fausto A, Chellaiah M, Feng X, McHugh KP, Teitelbaum SL, Civitelli R, Hruska KA, Ross FP, Avioli LV (2000) Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells. J Cell Biochem. 77(2):265-76. |
10723092 |
Lai CF, Feng X, Nishimura R, Teitelbaum SL, Avioli LV, Ross FP, Cheng SL (2000) Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling. J Biol Chem. 275(46):36400-6. |
10964912 |
Wan M, Shi X, Feng X, Cao X (2001) Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. J Biol Chem. 276(13):10119-25. Epub 2001 Jan 3. |
11139569 |
Feng X, Novack DV, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, Teitelbaum SL (2001) A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function. J Clin Invest. 107(9):1137-44. |
11342577 |
Gupta A, Tenenhouse HS, Hoag HM, Wang D, Khadeer MA, Namba N, Feng X, Hruska KA (2001) Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Bone. 29(5):467-76. |
11704500 |
Feng X, Takeshita S, Namba N, Wei S, Teitelbaum SL, Ross FP (2002) Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function. Endocrinology. 143(12):4868-74. |
12446614 |
Kintscher U, Lyon C, Wakino S, Bruemmer D, Feng X, Goetze S, Graf K, Moustakas A, Staels B, Fleck E, Hsueh WA, Law RE (2002) PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. Circ Res. 91(11):e35-44. |
12456495 |
Wang Q, Xie Y, Du QS, Wu XJ, Feng X, Mei L, McDonald JM, Xiong WC (2003) Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol. 160(4):565-75. |
12578912 |
Liu Y, Shi Z, Silveira A, Liu J, Sawadogo M, Yang H, Feng X (2003) Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiation. J Biol Chem. 278(23):20603-11. |
12663664 |
Xiong WC, Feng X (2003) PYK2 and FAK in osteoclasts. Front Biosci. 8:d1219-26. |
12957821 |
Zhang L, Feng X, McDonald JM (2003) The role of calmodulin in the regulation of osteoclastogenesis. Endocrinology. 144(10):4536-43. |
12960067 |
Wu X, McKenna MA, Feng X, Nagy TR, McDonald JM (2003) Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology. 144(12):5545-55. |
12960091 |
Wang S, Skorczewski J, Feng X, Mei L, Murphy-Ullrich JE (2004) Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. J Biol Chem. 279(33):34311-22. |
15184388 |
Pan G, Wu X, McKenna MA, Feng X, Nagy TR, McDonald JM (2004) AZT enhances osteoclastogenesis and bone loss. AIDS Res Hum Retroviruses. 20(6):608-20. |
15242537 |
Xu D, Shi Z, McDonald J, Pan G, Cao X, Yu X, Feng X (2004) Development of a chimaeric receptor approach to study signalling by tumour necrosis factor receptor family members. Biochem J. 383(Pt 2):219-25. |
15250821 |
Liu W, Xu D, Yang H, Xu H, Shi Z, Cao X, Takeshita S, Liu J, Teale M, Feng X (2004) Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function. J Biol Chem. 279(52):54759-69. |
15485878 |
Shi Z, Silveira A, Patel P, Feng X (2004) YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiation. Gene. 343(1):117-26. |
15563837 |
Shi Z, Silveira A, Patel P, Feng X (2004) YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiation. Gene. 343(1):117-26. |
15563837 |
Feng X (2005) Regulatory roles and molecular signaling of TNF family members in osteoclasts. Gene. 350(1):1-13. Review. |
15777737 |
Zhang L, McKenna MA, Said-Al-Naief N, Wu X, Feng X, McDonald JM (2005) Osteoclastogenesis: the role of calcium and calmodulin. Crit Rev Eukaryot Gene Expr. 15(1):1-13. |
15831075 |
Feng X (2005) RANKing intracellular signaling in osteoclasts. IUBMB Life. 57(6):389-95. Review. |
16012047 |
Liu J, Yang H, Liu W, Cao X, Feng X (2005) Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells. J Cell Biochem. 96(4):716-27. |
16052479 |
Wu Y, Liu J, Feng X, Yang P, Xu X, Hsu HC, Mountz JD (2005) Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum. 52(10):3257-68. |
16200600 |
Liu W, Wang S, Wei S, Sun L, Feng X (2005) Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4. J Biol Chem. 280(52):43064-72. |
16260781 |
Xu D, Wang S, Liu W, Liu J, Feng X (2006) A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage. J Biol Chem. 281(8):4678-90. |
16373338 |
Kim HK, Guan H, Zu G, Li H, Wu L, Feng X, Elmets C, Fu Y, Xu H (2006) High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals. J Leukoc Biol. 79(4):686-95. |
16461745 |
Zhou Z, Immel D, Xi CX, Bierhaus A, Feng X, Mei L, Nawroth P, Stern DM, Xiong WC (2006) Regulation of osteoclast function and bone mass by RAGE. J Exp Med. 203(4):1067-80. |
16606672 |
Cui T, Schopfer FJ, Zhang J, Chen K, Ichikawa T, Baker PR, Batthyany C, Chacko BK, Feng X, Patel RP, Agarwal A, Freeman BA, Chen YE (2006) Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. J Biol Chem. 281(47):35686-98. |
16887803 |
Chen T, Feng X (2006) Cell-based assay strategy for identification of motif-specific RANK signaling pathway inhibitors. Assay Drug Dev Technol. 4(4):473-82. Review. |
16945019 |
Wang S, Shi Z, Liu W, Jules J, Feng X (2006) Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing. BMC Biotechnol. 6:50. |
17187675 |
Takeshita S, Faccio R, Chappel J, Zheng L, Feng X, Weber JD, Teitelbaum SL, Ross FP (2007) c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages. J Biol Chem. 282(26):18980-90. |
17420255 |
Lu W, Kim KA, Liu J, Abo A, Feng X, Cao X, Li Y (2008) R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett. 582(5):643-50. |
18242177 |
Zhou Z, Han JY, Xi CX, Xie JX, Feng X, Wang CY, Mei L, Xiong WC (2008) HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE. J Bone Miner Res. 23(7):1084-96. |
18302500 |
Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michalek S, He Y, Yu M, Fu YX, Wen R, Wu H, Wang D (2008) Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. J Biol Chem. 283(43):29593-601. |
18728019 |
Liu J, Wang S, Zhang P, Said-Al-Naief N, Michalek SM, Feng X (2009) Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis. J Biol Chem. 284(18):12512-23. |
19258321 |
Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J (2009) Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis. J Biol Chem. 284(21):14667-76. |
19321441 |
Tang Y, Wu X, Lei W, Pang L, Wan C, Shi Z, Zhao L, Nagy TR, Peng X, Hu J, Feng X, Van Hul W, Wan M, Cao X (2009) TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med. 15(7):757-65. |
19584867 |
Feng X (2009) Chemical and Biochemical Basis of Cell-Bone Matrix Interaction in Health and Disease. Curr Chem Biol. 3(2):189-196. |
20161446 |
Jules J, Ashley JW, Feng X (2010) Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis. Expert Opin Ther Targets. 14(9):923-34. Review. |
20678025 |
Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT (2010) Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer. Cancer Gene Ther. 17(12):893-905. |
20798695 |
Jules J, Shi Z, Liu J, Xu D, Wang S, Feng X (2010) Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis. J Biol Chem. 285(48):37427-35. Epub 2010 Sep 24. |
20870724 |
Feng X, McDonald JM (2011) Disorders of bone remodeling. Annu Rev Pathol. 6:121-45. Review. |
20936937 |
Ashley JW, McCoy EM, Clements DA, Shi Z, Chen T, Feng X (2011) Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. Assay Drug Dev Technol. 9(1):40-9. |
21050071 |
Pan G, Zheng R, Yang P, Li Y, Clancy JP, Liu J, Feng X, Garber DA, Spearman P, McDonald JM (2011) Nucleosides accelerate inflammatory osteolysis, acting as distinct innate immune activators. J Bone Miner Res. 26(8):1913-25. |
21472777 |
Cui S, Xiong F, Hong Y, Jung JU, Li XS, Liu JZ, Yan R, Mei L, Feng X, Xiong WC (2011) APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner. J Bone Miner Res. 26(5):1084-98. |
21542009 |
Zhang P, Liu J, Xu Q, Harber G, Feng X, Michalek SM, Katz J (2011) TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB. J Biol Chem. 286 (27): 24159-69. |
21566133 |
Cheng J, Liu J, Shi Z, Xu D, Luo S, Siegal GP, Feng X, Wei S (2011) Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: a novel mechanism mediating its blockade of osteoclastogenesis. J Cell Biochem. 112(11):3385-92. |
21751242 |
Cody JJ, Rivera AA, Liu J, Liu JM, Douglas JT, Feng X (2011) A simplified method for the generation of human osteoclasts in vitro. Int J Biochem Mol Biol. 2(2):183-189. |
21968748 |
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