|
| Publication |
PUBMEDID |
Wang W, Fu L, Liu Z, Wen H, Rab A, Hong JS, Kirk KL, Rowe SM.G551D mutation impairs PKA-dependent activation of CFTR channel that can be restored by novel GOF mutations. Am J Physiol Lung Cell Mol Physiol
. 2020 Nov 1;319(5):L770-L785 |
32877225 |
Kathryn E Oliver 1, Robert Rauscher 2, Marjolein Mijnders 3, Wei Wang 4, Matthew J Wolpert 4, Jessica Maya 4, Carleen M Sabusap 4, Robert A Kesterson 5, Kevin L Kirk 4, Andras Rab 1, Ineke Braakman 3, Jeong S Hong 1, John L Hartman 4th 4 5, Zoya Ignatova 2, Eric J Sorscher. Slowing ribosome velocity restores folding and function of mutant CFTR. J Clin Invest
. 2019 Dec 2;129(12):5236-5253 |
31657788 |
| Doiron JE, Le CA, Ody BK, Brace JB, Post SJ, Thacker NL, Hill HM, Breton GW, Mulder MJ, Chang S, Bridges TM, Tang L, Wang W, Rowe SM, Aller SG, Turlington M. Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809. Chemistry. 2019 Jan 16 |
30650214 |
| Sabusap CM, Wang W, McNicholas CM, Chung WJ, Fu L, Wen H, Mazur M, Kirk KL, Collawn JF, Hong JS, Sorscher EJ.Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases.JCI Insight. 2016 Sep 8;1(14). |
27660821 |
| Raju SV, Lin VY, Liu L, McNicholas CM, Karki S, Sloane PA, Tang L, Jackson PL, Wang W, Wilson L, Macon KJ, Mazur M, Kappes J, DeLucas LJ, Barnes S, Kirk K, Tearney GT, Rowe SM. The CFTR Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating CFTR Inhibition by Cigarette Smoke Am J Respir Cell Mol Biol. 2016 Sep 1. |
PMID: 27585394 |
| Wang W, Hong JS, Rab A, Sorscher EJ, Kirk KL. Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators. PLoS One. 2016 Mar 23;11(3) |
PMID: 27007499 |
| Ehrhardt A, Chung WJ2, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, Sorscher EJ. Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. J Biol Chem. 2016 Jan 22;291(4):1854-65. |
PMID: 26627831 |
| Wang W, Roessler BC, Kirk KL. An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.J Biol Chem. 2014 Oct 31;289(44):30364-78. |
PMID: 25190805 |
| Okeyo G, Wang W, Wei S, Kirk KL.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations.J Biol Chem. 2013 Jun 14;288(24):17122-33. |
23620589 |
| Wang W, Okeyo GO, Tao B, Hong JS, Kirk KL. Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops. J Biol Chem. 286(49):41937-48,2011. |
21965669 |
| Kirk K, Wang W. A unified view of CFTR gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ABC transporter. J Biol Chem. 2011 Feb 4 |
21296873 |
Thibodeau PH, Richardson JM, Wang W, Millen L, Watson J, Mendoza JL, Du K, Fischman S, Senderowitz H, Lukacs GL, Kirk K, Thomas PJ.
The cystic fibrosis-causing mutation {Delta}F508 affects multiple steps in CFTR biogenesis. J Biol Chem. 2010 Jul 28. |
20667826 |
| Wang, W. Wu J, Bernard K, Li G, Wang G, Bevensee M, Kirk KL. ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc Natl Acad Sci U S A. 107:3888-93, 2010. |
20133716 |
| Bernard K, Wang W, Narlawar R, Schmidt B, Kirk KL. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol Chem. 284(45):30754-65, 2009. |
19740743 |
| Wang W, Bernard K, Li G and Kirk K L. Curcumin opens CFTR channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide binding domains J Biol Chem. 282(7):4533-44, 2007. |
17178710 |
| Li, Y. Wang W, Parker W, Clancy JP. Adenosine Regulation of CFTR through Prostenoids in Airway Epithelia. Am J Respir Cell Mol Biol. 34(5):600-608 2006. |
16399952 |
| Wang W, Li G, Clancy JP, Kirk KL. Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs. J Biol Chem. 280(25):23622-30, 2005. |
15857825 |
| Wang W, Oliva C, Li G, Holmgren A, Lillig CH, Kirk KL. Reversible silencing of CFTR chloride channels by glutathionylation. J Gen Physiol. 125(2):127-41, 2005. |
15657297 |
| Wang W, Hino N, Yamasaki H, Aoki T, Ochi R. KV2.1 K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts. Jpn J Physiol. 52(6):507-14, 2002. |
12617756 |
Yang D, Song L, W Zhu, Chakir K, Wang W, Wu C, Wang Y, Xiao R, Chen S.R.W, and Cheng H.
Calmodulin regulation of excitation-contraction coupling in cardiac myocytes. Circ Res 92:659-667, 2003.
|
12609973 |
| Wang W, Cleemann L, L, R Jones and Morad, M. Modulation of focal and global Ca2+ release in calsequestrin-overexpressing mouse cardiomyocytes. J Physiol. 524 (2):399-414, 2000. |
10766921 |
| Suzuki YJ, Wang W, Morad, M. Modulation of Ca2+ channel-gated Ca2+ release by W-7 in cardiac myocytes. Cell Calcium. 25(3):191-198, 1999. |
10378080 |
Wang W, Watanabe M, Nakamura T, Kudo Y, and Ochi, R. Properties and expression of
Ca2+-activated K+ channels in H9c2 cells derived from rat ventricle. Am J Physiol . 276:H1559-H1566, 1999.
|
10330239 |
| Cleemann L, Wang W, and Morad M. Two-dimensional confocal images of organization, density, and gating of focal Ca2+ release sites in rat cardiac myocytes. Proc Natl Acad Sci U.S.A. 95:10984-10989, 1998. |
9724816 |
Jones LR, Suzuki YJ, Wang W, Kobayashi YM, Ramesh V, Franzini-Armstrong C, Cleemann L, and
Morad M Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J Clin Invest. 101:1385-1393, 1998.
|
9525981 |
|
|
