Undergraduate |
Harvard University |
|
1965 |
A.B. Chemistry and Physics |
Graduate |
Johns Hopkins University |
|
1975 |
Ph.D. in Biophysics |
Medical School |
Johns Hopkins University School of Medicine |
|
1977 |
M.D. |
Residency |
Vanderbilt University |
|
1979 |
Anatomic Pathology |
Residency |
University of Alabama at Birmingham |
|
1981 |
Clinical Pathology |
|
American Board of Pathology, Anatomical and Clinical, Diplomate |
1982 |
|
Integrative Biomedical Sciences |
Molecular and Cellular Pathology Program |
|
Organization Name |
Position Held |
Org Link |
Alabama Society for Histotechnology (ASH) |
Honorary |
http://www.biologydir.com/alabama-society-for-histotechnology-info-40457.html |
American Association for Cancer Research (AACR) |
Editorial Board, Clinical Cancer Research |
http://www.aacr.org/ |
Biological Stain Commission (BSC) |
Former Vice-President, Former President, Former Trustee, Trustee Emeritus, Editorial Board, Biotechnic and Histochemistry |
https://biologicalstaincommission.org/ |
College of American Pathologists (CAP) |
Former Elected Member |
http://www.cap.org/ |
Endocrine Society |
Former Elected Member |
https://www.endocrine.org/ |
International Society for Biological and Environmental Repositories (ISBER) |
Former President, Former Member of the Board of Directors, Member of Publications and Science Policy Committees, 2015 ISBER Outstanding Achievements in Biobanking Award, 2019 ISBER Founder Award, Editorial Board, Biopreservation and Biobanking |
http://www.isber.org/ |
|
Publication |
PUBMEDID |
Vaklavas C, Zinn K, Samuel S, Meng Z, Grizzle W, Choio H, Blume S. Translational control of the undifferentiated phenotype in ER-positive breast tumor cells: cytoplasmic localization of ER-alpha and impact of IRES inhibition. Oncology Reports 2018;39(6);2482-2498. |
|
Abisoye-Ogunniyan A, Lin H, Ghebremedhin A, Salam A, Karanam B, Theodore S, Jones-Trich J, Davis M, Grizzle W, Wang H, Yates C. Transcriptional Repressor Kaiso Promotes Epithelial to Mesenchymal Transition and metastasis in prostate cancer through direct regulation of miR-200c. Cancer Lett. 2018 May 8. pii: S0304-3835(18)30319-7. doi: 10.1016/j.canlet.2018.04.044. [Epub ahead of print] PMID:29751044 |
|
Astrin JJ, Baker S, Barker K, Barr tj, Bartels P, Benson E, Berents P, Butler C, Cada M, Campbell LD, Campos AH, Carpentieri D, Carter C, Castelhano M, Clement O, Coppola D, De Souza Y, Dröge G, Estrada O, Fearn P, Feil K, Garcia D, Giri J, Grizzle WE, Groover K, Guevarra DM, Harding K, Henderson MJ, Huddleston DJ, Huppertz B, Jakubczak J, Joseph L, Kaercher E, Kessler J, Larson C, Loud S, Lyal C, Mackenzie-Dodds J, Maynor H, McCall S, McCluskey K, Meagher K, Michels C, Miranda L, Muller-Cohn J, Muller R, Mullins PF, O’Sullivan J, Palomo FJG, Patel AA, Petersen G, Pitt K, Potapova O, Pugh R, Radio PR, Ravid R, Rawley-Payne M, Revelez M, Robb J, Roehri M, Sanjur C, Schlief W, Seberg O, Sexton K, Shao W, Silva RLA, Skubitz A, Somiari S, Tsuruyama T, van der Horst F, Welch G, Zaayenga A, Zimkus BM. Best practices for repositories: Collection, storage, retrieval, and distribution of biological materials for research. Fourth Edition. Biopreservation and Biobanking 2018;1-103. |
|
Bledsoe MJ, Russell-Einhorn MK, Grizzle WE. Shifting sands: the complexities and uncertainties of the evolving US regulatory, policy, and scientific landscape for biospecimen research, Diagnostic Histopathology. 2017, https://doi.org/10.1016/j.mpdhp.2017.09.004 |
|
Van Neste L, Groskopf J, Grizzle WE, Adams, GW, DeGuenther MS, Kolettis PN, Bryant JE, Kearney GP, Kearney P, Van Crieking W, Gaston S. Epigenetic risk score improves prostate cancer risk assessment. The Prostate. 2017;77(12):1259-1264 PMID: 28762545 |
|
Zeiderman M, Morgan D, Christein J, Grizzle WE, McMasters K, McNally L. Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS Biomaterials Science & Engineering 2016;2(7):1108-1120 |
|
Grizzle WE, Bell WC, Sexton KC. Issues in collecting, processing and storing human tissues and associated information to support biomedical research. In: Translational Pathology of Early Cancer. (Eds. S Srivastava, WE Grizzle), IOS Press BV, Amsterdam. 2012;531-549 |
|
Grizzle WE, Srivastava S, Manne U. Translational Pathology of Cancer. In: Translational Pathology of Early Cancer. (Eds. S. Srivastava, WE Grizzle) IOS Press BV, Amsterdam. 2012;7-20 |
|
Varley KE, Gertz J, Roberts BS, Davis NS, Bowling KM, Kirby MK, Nesmith AS, Oliver PG, Grizzle WE, Forero A, Buchsbaum DJ, LoBuglio AF, Myers RM. Recurrent read-through fusion transcripts in breast cancer. Breast Cancer Res Treat 2014; 146(2):287-97 |
24929677 |
Stanley J, Klepczyk L, Keene K, Wei S, Li Y, Forero A, Grizzle W, Wielgos M, Brazelton J, LoBuglio AF, Yang ES. PARP1 and phosphor-p65 protein expression is increased in human HER2-positive breast cancers. Breast Cancer Res Treat 2015; 150(3):569-79 |
25833211 |
Vaklavas C, Meng Z, Choi H, Grizzle WE, Zinn KR, Blume SW. Small molecule inhibitors of IRES-mediated translation. Cancer Biol Ther 2015;16(10);1471-1485 |
26177060 |
Bhutiani N, Grizzle WE, Galandiuk S, Otali D, Dryden GW, Egilmez NK, McNally LR. Non-invasive Imaging of Colitis using Multispectral Optoacoustic Tomography.J Nucl Med 2017;58(6):1009-1012 |
27908970 |
Zhang HG, Grizzle WE. Exosomes: a novel pathway of local and distant intercellular communication that facilitate the growth and metastasis of neoplastic lesions. Am J Pathol 2014;184(1):28-41. |
38733490 |
Demark-Wahnefried W, Rais-Bahrami S, Desmond RA, Gordetsky JB, Hunter GR, Azrad M, Frugé AD, Nix JW, Sudarshan S, Tsuruta Y, Tully SA, Segal R, Chacko B, Grizzle WE. Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer. British Journal of Cancer, 2017;117(9):1303-1313. |
5672928 |
Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakratory SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora Kinase-A inactivates DNA damage induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 2012;21(2):196-211 |
PMC22340593 |
Srivastava SK, Bhardwaj A, Singh S, Arora S, McClellan S, Grizzle WE, Reeed E, Singh AP. Mb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance. Carcinogenesis 2012;33(6):1149-57 |
PMC22431717 |
Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S. CXCL12/CXCR4 signaling axis induces SHH expression in pancreatic cancer cells via ERK- and Akt- mediated activation of NF=κB: implications for bidirectional tumor-stromal interactions. J Biological Chem 2012;287(46):39115-24 |
PMC22995914 |
Gurpinar E, Grizzle WE, Shacka JJ, Mader B, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA. A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. Molecular Cancer Ther 2013;12(5):63-74. |
PMC23443799 |
Devine DJ, Rostas JW, Metge BJ, Das S, Mulekar MS, Tucker JA, Grizzle WE, Buchsbaum KJ, Shevde LA, Samant RS. Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activiation of TGF-β/SMAD signaling. Oncogene 2014; 33(20):2620-8 |
PMC23770854 |
Li H, Hsu HC, Wu Q, Yang P, Li J, Oukka M, Steele CH, Cua DJ, Grizzle WE, Mountz JD. IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt. Nature Comm 2014; 8(5):4259 |
PMC25001511 |
Birket SE, Chu KK, Liu L, Houser GH, Diephuis BJ, Wilsterman EJ, Dierksen G, Mazur M, Shastry S, Li Y, Watson JD, Smith AT, Schuster BS, Hanes J, Grizzle WE, Sorscher EJ, Tearney GJ, Rowe SM. A functional anatomic defect of the cystic fibrosis airway. Am J Respir Crit Care Med 2014;190(4):421-32 |
PMC25029666 |
Forero-Torres A, Varley KE, Abramson VG, Li Y, Vaklavas C, Lin NU, Liu MC, Rugo HS, Nanda R, Storniolo AM, Traina TA, Patil S, Hayes DF, Van Poznak CH, Nangia JR, Irvin Jr WJ, Krontiras H, De Los Santos JF, Haluska P, Grizzle W, Meyers RM, Wolff AC. TBCRC 019: phase II trial of nab-PAC with/without the anti-death receptor 5 monoclonal antibody tigatuzumab in patients with triple negative breast cancer. Clin Can Res 2015; 21(12):2722-9 |
PMC25779953 |
Kimbrough CW, Khanal A, Zeiderman M, Khanal BR, Burton NC, McMasters KM, Vickers S, Grizzle WE, McNally LR. Targeting acidity in pancreatic adenocarcinoma: multispectral optoacoustic tomography detects pH-low insertion peptide probes in vivo. Clin Can Res 2015 Oct 15:21(20):4576-85. doi: 10.1158/1078-0432.CCR-15-0314 |
PMC26124201 |
Yin W, Kimbrough Cw, Gomez-Gutierrez JG, Burns CT, CHuong P, Grizzle WE, McNally LR. Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography. J Nanobiotechnol 2015;13(1):90 |
PMC26627455 |
Forero A, Li Y, Chen D, Grizzle WE, Updike KL, Merz ND, Downs-Kelly E, Burwell TC, Vaklavas C, Buchsbaum DJ, Myers RM, LoBuglio AF, Varley KE. Expression of the MHC class II pathway in triple-negative breast cancer tumor cells is associated with a good prognosis and infiltrating lymphocytes. Cancer Immunol Res 2016 May;4(5):390-9 |
PMC26980599 |
Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Dronenberg M, Zhang HG. Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells. J Immunol 2013; 90(7):3579-89 |
PMC27207807 |
McNally LR, Mezera M, Morgan DE, Frederick PJ Yang ES, Eltoum I-E, Grizzle WE. Current and emerging clinical applications of multispectral optoacoustic tomography (MSOT) in oncolocy. Clinical Cancer Research 2016;22(14):3432-9 |
PMC27208064 |
Schultz MJ, Holdbrooks At, Chakraborty A, Grizzle WE, Landen Jr, CN, Buchsbaum DJ, Conner MG, Arend RC, Yoon K, Klug CA, Bullard DC, Kesterson RA, Oliver PG, O’Connor AK, Yoder BK, Bellis SL. The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription facors and confers a cancer stem cell phenotype. Cancer Res. 2016;76(13):3978-88 |
PMC27216178 |
Kirby MK, Ramaker R, Gertz J, Davis NS, Johnston BE, Oliver PG, Sexton KC, Christein JD, Heslin MJ, Posey JA, Grizzle WE, Green EW, Vickers SM, Buchsbaum DJ, Cooper SJ, Myers RM. RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4. Molecular Oncology 2016;10(8):1169-82 |
PMC27282075 |
Vaklavas C, Grizzle W, Choi H, Meng Z, Zinn K, Shrestha K, Blume SW. IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells. Tumour Biol 2016;37(10):13247-13264 |
PMC27460074 |
Grizzle WE, Otali D, Sexton KC, Atherton DS. Effects of Cold Ischemia on Gene Expression: A Review and Commentary. Biopreserv Biobank. 2016;14(6):548-558 |
PMC27551929 |
Ottman R, Levy J, Grizzle WE, Chakrabarti R. The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer. Oncotarget 2016;7(45):73739-73753 |
PMC27650639 |
Zhang H-G, Grizzle WE. Exosomes and Cancer: A newly described pathway of immune suppression. Clin Can Res 2011;17(5):959-64 |
PMC3155407 |
Li N, Lee K, Zhu B, Gary BD, Ramirez-Alcantara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP, Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA. Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity. Oncogene 2015; 19;34(12):1499-509 doi: 10.1038/onc.2014.94. Epub 2014 Apr 7 PMCID:PMC4212019 |
PMC4212019 |
Davis M, Tripathi S, Hughley R, He Q, Bae S, Karanam B, Martini R, Newman L, Colomb W, Grizzle W, Yates C. AR negative triple negative or “quadruple negative” breast cancers in African American women have an enriched basal and immune signature. PLOS One 13(6): e0196909. June 18, 2018. https://doi.org/10.1371/journal.pone.0196909. PMCID:PMC6005569. |
PMC6005569 |
|
|