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Faculty Detail    
Name UPENDER MANNE
Director, Translational Anatomic Pathology
Co-Director, UAB Tissue Bioreposity		  
Campus Address WTI 420A Zip 3300
Phone  (205) 934-4276
E-mail  upendermanne@uabmc.edu
Other websites Google Scholar
Research Gate
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Clinical Pathology  Anatomic Pathology Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Minority Health & Research Center  Minority Health & Research Center Professor
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor
Secondary  Surgery - General Surgery  Surgery - Gen Surg Gastrointestinal Section Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Manne obtained his M.S. (Biochemistry, Histochemistry, Parasitology, Zoonosis) and Ph.D. (energy metabolic pathways of endoparasites) degrees from Osmania University, Hyderabad, India. His postdoctoral training was in molecular immunology and vaccine development for malaria (Malaria Research Center, Delhi, India); in helicobacter infections (School of Microbiology, University of New South Wales, Sydney, Australia); and in histopathology, molecular tumor biology, cancer biomarker development, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). He also received certification in bioinformatics at UAB. Dr. Manne’s research on racial disparity in colorectal and breast cancers has received considerable national and international recognition. In 2009, as part of the Presidents Cancer Panel, Dr. Manne focused on “Biologic differences between ethnic groups and their clinical implications in cancer care,” and devoted to the topic, “America’s demographic and cultural transformation: implications for the cancer enterprise.” Currently, he is the Principal Investigator of two Comprehensive Cancer Research Partnership between UAB Comprehensive Cancer Center and Tuskegee University, Tuskegee, AL and Morehouse School of Medicine, Atlanta, GA (U54); and Alabama State University, Montgomery, AL (P20) to Reduce Cancer Health Disparities by implementing innovative, multi-disciplinary, collaborative, population-based cancer control and prevention research and has contributed to education, training, and community outreach activities. These two programs are funded by the National Cancer Institute of the National Institute of Health.

Society Memberships
Organization Name Position Held Org Link
American Society of Clinical Oncology  Active member   
American Association for Cancer Research  Active member   
 



Research/Clinical Interest
Title
Translational research in grastrointestinal malignancies and breast cancer
Description
Dr. Manne’s present efforts are focused on population-based translational research for human neoplasias, with emphasis on colorectal and breast cancers. His laboratory, with projects funded by the National Cancer Institute and the Susan G. Komen Foundation, is evaluating molecular markers to identify aggressive phenotypic features of tumors to predict the efficacy of chemotherapeutic regimens and to assess clinical outcomes. Dr. Manne’s research and collaborative groups include experts in the fields of molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. For evaluating the clinical utility of genetic and phenotypic abnormalities in colorectal cancer, his group has developed strategies demonstrating that the utility of molecular biomarkers varies according to the anatomic location of tumors within the colorectum and with tumor stage, race/ethnicity, age, and gender. To validate the clinical utility of genetic and phenotypic markers, Dr. Manne’s laboratory is evaluating hundreds of colorectal cancer samples derived from African American and non-Hispanic Caucasian ethnic/racial backgrounds and collected from different institutions. Established molecular markers with be merged with other epidemiological, environmental, and socio-economic features to find the basis for racial disparities in colorectal and breast malignancies. Results from approaches involving biomarker discovery and bioinformatics will aid in developing predictive models specific for individual patients. The research interests of Dr. Manne also include use of genomics and proteomics for identification of early markers of cancers, specifically, identification of molecular signatures of benign colonic epithelium, which is at risk of developing colorectal neoplasias, and of other pre-malignant lesions. These studies will aid in the evaluation of molecular and pathologic characteristics of specimens and in the development of assays that relate to early detection, diagnosis, prognosis, and treatment of cancers.

Selected Publications 
Publication PUBMEDID
Narayanan NK, Kunimasa K, Yamori Y, Mori M, Mori H, Nakamura K, Miller G, Manne U, Tiwari AK, Narayanan B. Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo.Cancer Med. 2015;4(11):1767-80.   26408414 
Tabatabai MA, Kengwoung-Keumo JJ, Eby WM, Bae S, Manne U, Fouad M, Singh KP.A New Robust Method for Nonlinear Regression. J Biom Biostat. 2014;5(5):211  26185732 
Tabatabai MA, Li H, Eby WM, Kengwoung-Keumo JJ, Manne U, Bae S, Fouad M, Singh KP.Robust Logistic and Probit Methods for Binary and Multinomial Regression.J Biom Biostat. 2014;5(4). pii: 202.  26078914  
Putcha BD, Jia X, Katkoori VR, Salih C, Shanmugam C, Jadhav T, Bovell LC, Behring MP, Callens T, Messiaen L, Bae S, Grizzle WE, Singh KP, Manne U.Clinical Implications of Rabphillin-3A-Like Gene Alterations in Breast Cancer.PLoS One. 2015 12;10(6):e0129216.   26070152 
Fadlalla K, Elgendy R, Gilbreath E, Pondugula SR, Yehualaeshet T, Mansour M, Serbessa T, Manne U, Samuel T.3-(2-Bromoethyl)-indole inhibits the growth of cancer cells and NF-κB activation.Oncol Rep. 2015;34(1):495-503.  26063116  
Bumpers HL, Janagama DG, Manne U, Basson MD, Katkoori V.Nanomagnetic levitation three-dimensional cultures of breast and colorectal cancers.J Surg Res. 2015;194(2):319-26.  25617973 
Karthikeyan C, Lee C, Moore J, Mittal R, Suswam EA, Abbott KL, Pondugula SR, Manne U, Narayanan NK, Trivedi P, Tiwari AK. IND-2, a pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells.Bioorg Med Chem. 2015;23(3):602-11.  25537531 
Tabatabai MA, Kengwoung-Keumo JJ, Eby WM, Bae S, Guemmegne JT, Manne U, Fouad M, Partridge EE, Singh KP.Disparities in cervical cancer mortality rates as determined by the longitudinal hyperbolastic mixed-effects type II model.PLoS One. 2014;9(9):e107242.   25226583  
Samuel T, Fadlalla K, Gales DN, Putcha BD, Manne U.Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs.BMC Cancer. 2014 Aug 18;14:599.   25134433 
Gales D, Clark C, Manne U, Samuel T.The Chemokine CXCL8 in Carcinogenesis and Drug Response. ISRN Oncol. 2013;2013:859154 (Review).   24224100 
Bovell LC, Shanmugam C, Putcha BD, Katkoori VR, Zhang B, Bae S, Singh KP, Grizzle WE, Manne U.The Prognostic Value of MicroRNAs Varies with Patient Race/Ethnicity and Stage of Colorectal Cancer.Clin Cancer Res. 2013 Jul 15;19(14):3955-65.  23719259 
Bovell LC, Putcha BD, Samuel T, Manne U.Clinical implications of microRNAs in cancer.Biotech Histochem. 2013 Oct;88(7):388-96  23647010 
Vogtmann E, Shanmugam C, Katkoori VR, Waterbor J, Manne U.Socioeconomic status, p53 abnormalities, and colorectal cancer.J Gastrointest Oncol. 2013 Mar;4(1):40-4.   23450636 
McNally L, Manne U, Grizzle WE.Post-transcriptional processing of genetic information and its relation to cancer.Biotech Histochem. 2013;88(7):365-72.  23286224 
Katkoori VR, Manne K, Vital-Reyes VS, Rodríguez-Burford C, Shanmugam C, Sthanam M, Manne U, Chatla C, Abdulkadir SA, Grizzle WE.Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53. Biotech Histochem. 2013 Jan;88(1):38-46.  23167625 
Katkoori VR, Suerez-Curvo C, Shanmugam C, Bumpers, H, Posey J, Grizzle, WE, Manne U. Bax expression is a prognostic and predictive marker in colorectal cancer. J. Gastrointest Oncol, 2010;1:76-89.   22811811 
Bowman E, Oprea G, Okoli J, Gundry K, Rizzo M, Gabram-Mendola S, Manne U, Smith G, Pambuccian S, Bumpers HL. Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients.Breast J. 2012 May-Jun;18(3):242-7.   22583194 
Tuupanen S, Yan J, Turunen M, Gylfe AE, Kaasinen E, Li L, Eng C, Culver DA, Kalady MF, Pennison MJ, Pasche B, Manne U, de la Chapelle A, Hampel H, Henderson BE, Le Marchand L, Hautaniemi S, Askhtorab H, Smoot D, Sandler RS, Keku T, Kupfer SS, Ellis NA, Haiman CA, Taipale J, Aaltonen LA.Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583. Cancer Genet. 2012 Jan-Feb;205(1-2):25-33.  22429595 
Katkoori VR, Shanmugam C, Jia X, Vitta SP, Sthanam M, et al. () Prognostic Significance and Gene Expression Profiles of p53 Mutations in Microsatellite-Stable Stage III Colorectal Adenocarcinomas. PLoS ONE, 2012;7(1): e30020. doi:10.1371/journal.pone.0030020  22276141 
Samuel T, Fadlalla K, Mosley L, Katkoori V, Turner T, Manne U.Dual-mode Interaction between Quercetin and DNA-damaging Drugs in Cancer Cells.Anticancer Res. 2012 Jan;32(1):61-71.  22213289 
Bovell L, Shanmugam C, Katkoori VR, Zhang B, Vogtmann E, Grizzle WE, Manne U.miRNAs are stable in colorectal cancer archival tissue blocks.Front Biosci (Elite Ed). 2012 Jan 1;4:1937-40.  22202009 
Manne U, Shanmugam C, Katkoori VR, Bumpers HL, Grizzle WE.Development and progression of colorectal neoplasia (Review).Cancer Biomark., 2011;9(1-6):235-65.  22112479 
Grizzle WE, Srivastava S, Manne U. Translational pathology of neoplasia. Cancer Biomark. 2010;9(1-6):7-20 (Review).  22112467 
Kennedy RD, Bylesjo M, Kerr P, Davison T, Black JM, Kay EW, Holt RJ, Proutski V, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, McDyer F, Mulligan K, Mussen J, O'Brien E, Oliver G, Walker SM, Mulligan JM, Wilson C, Winter A, O'Donoghue D, Mulcahy H, O'Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe OF, Winqvist O, Manne U, Shanmugam C, Ramaswamy S, Leon EJ, Smith WI Jr, McDermott U, Wilson RH, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG, Harkin DP.Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue. J Clin Oncol. 2011 Dec 10;29(35):4620-6.  22067406 
Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey JA Jr, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U.Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer.J Hematol Oncol. 2011, 28;4:25.  21619690 
Wang CW, Manne U, Reddy VB, Oelschlager DK, Katkoori VR, Grizzle WE, Kapoor R.Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples.J Biomed Opt,2010; 15(6):067005.  21198209 
Manne U, Shanmugam C, Bovell L, Katkoori VR, Bumpers HL:miRNAs as biomarkers for management of patients with colorectal cancer.Biomark Med. 2010 Oct;4(5):761-70.  20945991  
Atha DH, Manne U, Grizzle WE, Wagner PD, Srivastava S, Reipa V.Standards for immunohistochemical imaging: a protein reference device for biomarker quantitation. J Histochem Cytochem. 2010 Nov;58(11):1005-14.  20805583 
Shanmugam C, Jhala NC, Katkoori VR, Wan W, Meleth S, Grizzle WE, Manne U.Prognostic value of mucin 4 expression in colorectal adenocarcinomas.Cancer. 2010 Aug 1;116(15):3577-86.  20564074  
Anderson B, Hardin JM, Alexander DD, Grizzle WE, Meleth S, Manne U. Comparison of the predictive qualities of three prognostic models of colorectal cancer.Front Biosci (Elite Ed)., 2010 Jun 1;2:849-56.  20515758  
Harrington W, Bond V, Huang MB, Powell M, Lillard J, Manne U, Bumpers H.HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis. Mol Cell Pharmacol. 2009 Aug 5;1(2):85-91.  20383296 
Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S.Smad signaling is required to maintain epigenetic silencing during breast cancer progression.Cancer Res. 2010 Feb 1;70(3):968-78.
 		 20086175 
Hines RB, Shanmugam C, Waterbor JW, McGwin G Jr, Funkhouser E, Coffey CS, Posey J, Manne U.Effect of comorbidity and body mass index on the survival of African-American and Caucasian patients with colon cancer.Cancer. 2009 Dec 15;115(24):5798-806.
 		 19937953 
Hines RB, Chatla C, Bumpers HL, Waterbor JW, McGwin G Jr, Funkhouser E, Coffey CS, Posey J, Manne U.Predictive capacity of three comorbidity indices in estimating mortality after surgery for colon cancer.J Clin Oncol. 2009 Sep 10;27(26):4339-45.  19652054 
Meleth S, Chatla C, Katkoori VR, Anderson B, Hardin JM, Jhala NC, Bartolucci A, Grizzle WE, Manne U.Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker database.Cancer Inform. 2007 Mar 2;3:115-22.  19455238 
Katkoori VR, Jia X, Shanmugam C, Wan W, Meleth S, Bumpers H, Grizzle WE, Manne U.Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma.Clin Cancer Res. 2009;15(7):2406-16.  19339276 
Grizzle WE, Semmes OJ, Bigbee W, Zhu L, Malik G, Oelschlager DK, Manne B, Manne U.The need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis.Cancer Inform. 2005;1:86-97.  19305634 
Grizzle WE, Semmes OJ, Bigbee W, Zhu L, Malik G, Oelschlager DK, Manne B, Manne U.The need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis.Cancer Inform., 2005;1:86-97.  19305634 
Shanmugam C, Katkoori VR, Jhala NC, Grizzle WE, Manne U.Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas.Biotech Histochem. 2009 Apr;84(2):39-45.   19212825 
Chhieng D, Hardin M, Anderson B, Manne U. Predicting 5-year survival of colorectal carcinoma patients using data mining methods. AMIA Proc. 2007 Oct 11:907.  18694007 
Shanmugam C, Katkoori VR, Jhala NC, Grizzle WE, Siegal GP, Manne U.p53 Nuclear Accumulation and Bcl-2 Expression in Contiguous Adenomatous Components of Colorectal Adenocarcinomas Predict Aggressive Tumor Behavior.J Histochem Cytochem. 2008 Mar;56(3):305-12.  18071066 
Alexander DD, Waterbor J, Hughes T, Funkhouser E, Grizzle W, Manne U.African-American and Caucasian disparities in colorectal cancer mortality and survival by data source: an epidemiologic review.Cancer Biomark. 2007;3(6):301-13.   18048968 
Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U.Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.Front Biosci. 2008 Jan 1;13:1050-61.   17981610  
Manne U. Understanding racial differences in colorectal cancer aids in individualized medicine. Future Oncol., 2007 Jun;3(3):235-41.  17547516 
Benavides MA, Oelschlager DK, Zhang HG, Stockard CR, Vital-Reyes VS, Katkoori VR, Manne U, Wang W, Bland KI, Grizzle WE. Methionine inhibits cellular growth dependent on the p53 status of cells. Am J Surg. 2007 Feb;193(2):274-83.
 		 17236862 
Chatla C, Jhala NC, Katkoori VR, Alexander D, Meleth S, Grizzle WE, Manne U. Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinoma. Cancer Biomarkers 2005, 1:241-250.   17192048 
Baker AC, Eltoum I, Curry RO, Stockard CR, Manne U, Grizzle WE, Chhieng D.Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix.Arch Pathol Lab Med. 2006 Oct;130(10):1510-5.  17090193 
Jhala N, Jhala D, Vickers SM, Eltoum I, Batra SK, Manne U, Eloubeidi M, Jones JJ, Grizzle WE. Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates.
Am J Clin Pathol. 2006 Oct;126(4):572-9.
 		 17019794  
Verma M, Manne U. Genetic and epigenetic biomarkers in cancer diagnosis and identifying high risk populations. Crit Rev Oncol Hematol. 2006 Oct;60(1):9-18. 2006 Jul 10. Review.  16829121 
Manne U, Srivastava RG, Srivastava S. Keynote review: Recent advances in biomarker application in cancer diagnosis and treatment. Drug Discovery Today 2005, 10: 965-976.  16023055 
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Keywords
Colorectal Cancer, GI malignancies, Breast Cancer, Molecular Biomarkers, Racial/Ethnic Disparities, Cancer Control & Prevention