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Faculty Detail    
Campus Address CIRC 320E
Phone  205-934-0741
Other websites

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pediatrics   Ped - Neurology Professor
Secondary  Genetics   Genetics Chair Office Professor
Secondary  Neurobiology  Neurobiology Professor
Secondary  Neurology   Neurology Chair Office Professor
Secondary  Psychology  Psychology Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor

Graduate Biomedical Sciences Affiliations
Integrative Genetics Graduate Program 
Medical Scientist Training Program 

Biographical Sketch 
Associate Director, CIRC
Director, Civitan Sparks Clinics

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
(if applicable) YEAR(s) FIELD OF STUDY
Harvard College AB 1960 Biochemistry
Stanford University MD 1965 Medicine
Stanford University Residency 1969 Pediatrics
Johns Hopkins University Fellowship 1971 Pediatric Neurology

Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch.
Positions and Honors:
1971-72 Assistant Professor of Neurology, Johns Hopkins Univ., Sch Med, Baltimore, MD
1972-76 Assistant Professor of Pediatrics, Charles R. Drew PG Med Sch & Martin Luther King, Jr Hosp; Asst. Prof-in Residence, Step II, Dept Peds, UCLA Sch of Med 1976-77 Director, Office of Research Programs, Charles R. Drew PG Med School
1976-79 Associate Professor of Pediatrics, Charles R. Drew PG Med Sch & MLK Gen Hosp
1977-79 Associate Dean, Office of Research, Charles R. Drew PG Med School
1979-88 Associate Professor of Pediatrics (Neurology), Baylor College of Med, Houston
1988-92 Professor of Pediatrics (Neurology) Baylor College of Med, Houston
1992-03 Professor and Director, Div. of Pediatric Neurology, UAB School of Med
1992- Director, Clinical Neuroscience, Civitan International Research Center for Developmental and Learning Disorders, UAB
1994-02 Vice-Chairman of Medical Services, Dept. of Pediatrics, UAB
1993-96 Member, National Advisory Council, National Institute of Neurological Disorders and Stroke, NIH
1998-05 Director, American Board of Psychiatry and Neurology
2002- Associate Director, Civitan International Research Center
2002 Doctor Honoris Causa Gteborg University, Gteborg, Sweden
2005-06 President, American Board of Psychiatry and Neurology
2005- PI, MRRC

Society Memberships
Organization Name Position Held Org Link
American Academy of Neurology     
American Neurological Association  2nd Vice Preisdent, 2007-2008   
American Pediatric Society     
Child Neurology Society  President, 1997-1999   
Society for Neurochemistry     

Research/Clinical Interest
Rare Disease CRC for New Therapies and New Diagnostics
Rare Disease multisite initiative to provide natural history data leading to possible therapies for Rett syndrome, Angelman syndrome, and Prader-Willi syndrome. Dr. Percy's focus is Rett syndrome. This is patient-oriented research examining potential phenotype-genotype correlations and related aspects in a large cohort of participants. Role: Grant Co-PI, Rett syndrome Subcontract PI

Selected Publications 
Publication PUBMEDID
Zachor DA, Moore JF, Brezausek C, Theibert A, Percy AK. Cocaine inhibits NGF-induced PC12 cell differentiation through D1type dopamine receptors. Brain Res 869:85-97, 2000.

Zachor DA, Moore JF, Brezausek CM, Theibert AB, Percy AK. Cocaine inhibition of differentiation in NGF-induced PC12 cells is independent of ras signaling. Int J Dev Neuroscience 18:765-772, 2000.

Satoi M, Matsuishi T, Yamada S, Yamashita Y, Ohtaki E, Mori K, Riikonen R, Kato H, Percy AK. Decreased cerebrospinal fluid levels of -phenylethylamine in patients with Rett syndrome. Ann Neurol 47:801-803, 2000.

Amir R, Van den Veyver I, Schultz R, Malicki D, Tran C, Philippi A, Percy AK, Motil K, Lichtarge O, Smith EO, Glaze DG, Zoghbi HY. Influence of mutation type and X chromosome inactivation on the phenotype of Rett syndrome. Ann Neurol 47:670-679, 2000.

Kyllerman M, Mnsson J-E, Lichtenstein M, Percy AK, Nordborg C. Distal infantile neuroaxonal dystrophy-a new familial variant with perineuronal argyrophilic bodies. Acta Neuropathol 102:83-88,2001.

Hagberg, B., Hanefeld, F., Percy, A., Skjeldal, O. An update on clinically applicable diagnostic criteria in Rett syndrome. European J Paediatr Neurology 6:293-297,2002.

Breedveld G, Percy AK, Srinidhi L, de Vries BBA, Yapijakis C, Dure LS, Ippel E, Sandkuijl LA, MacDonald ME, Heutink P, Arts WFM. Clinical and Genetic Heterogeneity in Benign Hereditary Chorea. Neurology 59:579-584,2002.

Breedveld G, van Dongen JWF, Danesino C, Guala A, Percy AK, Dure LS, Harper P, van Linde H, Joosse M, MacDonald ME, de Vries BBA, Arts WFM, Oostra BA, Krude H, Heutink P. Mutations in TITF-1 are associated with Benign Hereditary Chorea. Hum Molec Genet 11:971-979,2002.

Schanen C, Houwink-Manville I, Dorrani N, Lane J, Everett R, Feng A, Cantor RM, Percy A. Phenotypic Manifestations of MECP2 Mutations in Classical and Atypical Rett Syndrome. Am J Med Genet 126A:129-140, 2004.

Amir RE, Fang P, Yu Z, Glaze D, Percy AK, Zoghbi HY, Roa BB, Van den Veyver, IB. Mutations in exon 1 of MECP2 are a rare cause of Rett Syndrome. J Medical Genet, on-line publication, 2004.

Neul JL, Maricich SM, Islam M, Barrish J, Smith EO, Bottiglieri T, Hyland K, Humphreys P, Percy A, Glaze D. Spinal fluid 5-methyltetrahydrofolate levels are normal in Rett Syndrome. Neurology 64:2151-2152, 2005.

Deidrich K, Percy A, Schanen N, Mamounas L, Maria B. Rett Syndrome: Pathogenesis, Diagnosis, Strategies, Therapies, and Future Directions. J Child Neurol 20:708-717, 2005.

Percy A, Lane J. Rett Syndrome: Model of Neurodevelopmental Disorders. J Child Neurol 20:718-721, 2005.

Tofil N, Buckmaster M, Callans B, Winkler M, Islam M, Percy A. Deep sedation with Propofol in patients with Rett syndrome. J Child Neurol 21:210-213, 2006.

Kankirawatana P, Leonard H, Ellaway C, Scurlock J, Mansour A, Makris CM, Dure LS, Friez M, Lane J, Kiraly-Borri C, Fabian V, Davis M, Jackson J, Christodoulou J, Kaufmann WE, Ravine D, Percy AK. Early Progressive Encephalopathy in Boys and MECP2 Mutations. Neurology 67:164-166,2006.

Percy AK, Lane JB, Childers J, Skinner S, Annese F, Barrish J, Caeg E, Glaze DG, MacLeod P. Rett Syndrome: North American Database. J Child Neurol in press, 2007.

Rett syndrome, MECP2, phenotype, genotype, natural history, longevity