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Faculty Detail    
Name QIN WANG
Professor
 
Campus Address MCLM 554 Zip 0005
Phone  205-996-5099
E-mail  qinwang@uab.edu
Other websites
     

Education
Medical School  Beijing Medical University    1992  MD 
Graduate  University of Iowa    1999  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  Neurology   Alzheimer's Disease Center Professor
Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor
Secondary  Neurobiology  Neurobiology Associate Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Integrative Biomedical Sciences 
Neuroscience 
Neuroscience Graduate Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Qin Wang received her M.D. degree from Beijing Medical University, China. After traveling to the US, she obtained her Ph.D. degree in December 1999 from University of Iowa. She then did her postdoc work at Vanderbilt University, where she was appointed as a Research Assistant Professor two years later. In June 2005, Dr. Wang joined UAB as an Assistant Professor.

Society Memberships
Organization Name Position Held Org Link
American Heart Association     
American Physiology Society     
American Society for Pharmacology and Experimental Therapeutics     



Research/Clinical Interest
Title
GPCR pharmacology and signaling in neurological and psychiatric diseases
Description
The lab has a general interest in G protein-coupled receptor (GPCR) pharmacology and signaling in the nervous system and their functions in physiological and pathological processes. Our goal is to provide new insights into development of therapeutic interventions for treatment of neurological and psychiatric diseases.

Selected Publications 
Publication PUBMEDID
Gannon M and Wang Q (2018) Complex noradrenergic dysfunction in Alzheimer's disease: Low norepinephrine input is not always to blame. Brain Res. Epub. Jan. 4.   
Chen Y, Booth C, Wang H, Wang RX, Terzi D, Zachariou V, Zhang J, Jiao K and Wang Q (2017) Effective attenuation of adenosine A1R signaling requires neurabin dimerization. Mol Pharm., 92, 630-639.
 
 
Zhang F, Gannon M, Chen Y, Zhou L, Jiao K and Wang Q (2017) The amyloid precursor protein modulates α2A adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment. FASEB J. 31, 4434-4446.
 
 
Wu H, Cottingham C, Wang H, Che P, Wang RX, Jiao K and Wang Q (2017) Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin. PLoS One. 12(7):e0180638.    
Scarduzio M, Zimmerman CN, Jaunarajs KL, Wang Q, Standaert DG and McMahon L (2017) Elevated striatal cholinergic tone drives dopamine D2 receptor mediated paradoxical excitation of cholinergic interneurons in DYT1 dystonia. Exp Neurol. 295, 162-175.
 
 
Reyes B, Carvalho AF, Szot P, Kalamarides D, Wang Q, Kirby L, Van Bockstaele E (2017) Cannabinoid regulation of cortical adrenergic receptor function. Exp Neurol., 292, 179-192.
 
 
Cottingham C, Che P, Zhang W, Wang H, Wang RX, Percival S, Birky T, Zhou L, Jiao K and Wang Q (2017) Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct2A adrenergic receptor ligands. Neuropharmacology, 116, 38-49.
 
 
Peng Y, Song L, Li D, Kesterson R, Wang J, Wang L, Wu B, Wang Q and Jiao K (2016) Sema6D acts downstream of BMP signaling to promote atrioventricular cushion development in mice. Cardiovasc Res., 112, 532-542.
 
 
Gannon M and Wang Q (2016). Alpha2A-adrenergic receptor. “Encyclopedia of Signaling Molecules” (ed. S. Choi). 2nd Edition. Springer-Verlag New York.
 
 
Che P, Chen Y, Lu R, Peng N, Gannon M, Wyss JM, Jiao K and Wang Q (2015) Spinophilin is indispensable for the α2B adrenergic receptor-elicited hypertensive response. PLoS One. 10(8):e0135030.
 
 
Gannon M, Che P, Chen Y, Jiao K, Roberson E and Wang Q (2015). Noradrenergic dysfunction in Alzheimer’s disease. Front Neurosci. Jun 17;9:220.
 
 
Cottingham C, Ferryman CJ and Wang Q (2015). 2 adrenergic receptor trafficking as a target of action by antidepressant therapeutics. Prog Mol Biol Transl Sci., 132, 207-225.
 
 
Hall AM, Throesch BT, Buckingham SC, Peng Y, Wang Q, Hoffman DA, and Roberson ED (2015) Tau-dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer’s Disease. J Neurosci., 35, 6221-6230.
 
 
Chen Y, Peng Y, Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K and Wang Q(2014) alpha2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction. Proc Natl Acad Sci, 111, 17296-17301.
 
 
Cottingham C, Percival S, Birky T and Wang Q (2014) Tricyclic antidepressants exhibit variable pharmacological profiles at the alpha2A adrenergic receptor. Biochem Biophys Res Commun., 451, 461-466.
 
 
Cathel AM, Reyes BAS, Wang Q, Mackie K, Van Bockstaele EJ and Kirby LG (2014) Cannabinoid modulation of alpha2 adrenergic receptor function in murine medial prefrontal cortex. Eur J Neurosci. 40, 3202-3214..
 
 
Flavin SA, Matthews RT, Emeson RB, Wang Q, Muly EC, and Winder DG (2014) Alpha2a-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis. J Neurosci., 34, 9319-9331.
 
 
De Fusco M, Vago R, Striano P, Di Bonaventura C, Zara F, Mei D, Kim MS, Muallem S, Chen Y, Wang Q, Guerrini R and Casari G (2014) The alpha2B adrenergic receptor is mutant in cortical myoclonus and epilepsy. Ann. Neurol. 75, 77-87.
 
 
Cottingham C, Lu R, Jiao K and Wang Q (2013) Cross-talk from beta2 adrenergic receptors modulates alpha2A adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin. J Biol Chem., 288, 29193-29205.
 
 
Cottingham C and Wang Q (2012). Alpha2 adrenergic receptor dysregulation in depressive
disorders: implications for depressive neurobiology and antidepressant therapy. Neurosci
Biobehav Rev. 36, 2214-2225. 
 
Cottingham C, Jones A and Wang Q (2012) Desipramine selectively potentiates
norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. Biochem Biophys Res Commun. 420, 161-165. 
 
Cottingham C, Li X and Wang Q (2012) Noradrenergic antidepressant responses in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology 62, 2353-2361.   
Chen Y, Liu Y, Cottingham C, McMahon L, Jiao K, Greengard P and Wang Q (2012) Neurabin scaffolding of the adenosine receptor and RGS4 regulates anti-seizure effect of adenosine. J Neurosci., 32, 2683-2695. (Commentary on Purinergic signal. 2012, 8:659; Highlighted on Nature SciBX: Science-Business eXchange, and on Global Medical
Discovery). 
 
Cottingham C, Chen H, Chen Y, Peng Y and Wang Q (2011). Genetic variations of alpha2 adrenergic receptors illuminate the diversity of receptor functions. Curr Top Membr. 67, 161-190.   
Cottingham C, Chen Y, Jiao K and Wang Q (2011) Desipramine is an arrestin-biased ligand at the alpha 2A adrenergic receptor driving receptor downregulation in vitro and in vivo. J Biol Chem., 286, 36063-36075. (Highlighted in Faculty of 1000).   
DeBenedittis P, Harmelink C, Chen Y, Wang Q, Jiao K (2011) Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem Biophys Res Commun. 409, 338-343.   
Nie X, Brown B, Wang Q and Jiao K (2010) Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling. Cells Tissues Organs. 193, 393-403.    
Lu R, Chen Y, Peng N, Jiao K, Limbird LE, Wyss JM and Wang Q (2010) Hypnotic and hypotensive responses to alpha2-adrengergic agent are potentiated and accompanied by enhanced G protein coupling to the receptor in spinophilin null mice. Mol. Pharm. 78, 279-286.   
Shields AD, Wang Q, Winder DG (2009) Alpha2A-Adrenergic Receptors Heterosynaptically Regulate Glutamatergic and GABAergic transmission in the BNST. Neuroscience, 163, 339-351.    
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q (2009) Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization. J Biol Chem., 284, 13233-13243.   
Nag S, Wang Q, Limbird LE, Mokha SS (2008) Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behav Brain Res., 197, 457-461.   
Xu J, Chen Y, Lu R, Cottingham C, Jiao K and Wang Q (2008) PKA phosphorylation of spinophilin modulates its interaction with the alpha2AAR and alters temporal properties of alpha2AAR internalization. J Biol Chem., 283, 14516-14523.   
Nie X, Deng CX, Wang Q, Jiao K (2008) Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev. Biol. 316, 417-430.   
Song L, Yan W, Chen X, Deng CX, Wang Q and Jiao K (2007) Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ. Res., 101, 277-285.   
Wang Q and Limbird LE (2007) Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochem Pharmacol. 73, 1135-1145. (Wang Q. is the corresponding author).   
Wang Q, Roujian Lu, Zhao J and Limbird LE (2006) Arrestin determines the temporal and spatial activation G-protein-mediated ERK by endogenous alpha2-adrenergic receptors. J Biol Chem., 281, 25948-25955. (Wang Q. is the corresponding author).   
Brady AE, Wang Q, Rizzo M, Greengard P and Limbird LE (2005) Alpha2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha2A-subtype. Mol Pharm. 67, 1690-1696. (Wang Q. is the corresponding author).   
Brady AE, Wang Q, Limbird LE (2004) Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods Mol Biol., 259, 371-378.   
Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P and Limbird LE (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
Science 304, 1940-1944 (Research Article, highlighted in Faculty of 1000). 
 
Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P and Limbird LE (2003) Spinophilin stabilizes cell surface expression of alpha2B-adrenergic receptors. J Biol Chem 278, 32405-32412.   
Wang Q and Limbird LE (2002) Regulated interactions of the alpha2A-adrenergic receptor with spinophilin, 14-3-3 zeta, and arrestin 3. J Biol Chem 277, 50589-50596.   

Keywords
GPCR, membrane protein trafficking, signaling, ligand regulation, neurodegeneration, neuroprotection, Alzheimer's disease, cognition, mood disorders