Appointment Type |
Department |
Division |
Rank |
Primary |
Cell, Developmntl, & Integrative Biology |
Cell, Developmntl, & Integrative Biology |
Professor |
Center |
GL Ctr for Craniofacial, Oral, & Dental Disorders |
GL Ctr for Craniofacial, Oral, & Dental Disorders |
Professor |
|
Cellular and Molecular Biology Program |
Hughes Med-Grad Fellowship Program |
Integrative Biomedical Sciences |
Neuroscience |
Pathobiology and Molecular Medicine |
Waiting to be Seated |
|
Publication |
PUBMEDID |
Naren, A.P., M.W. Quick, J. Collawn, D.J.Nelson and K.L. Kirk. Syntaxin 1A inhibits CFTR chloride channel via domain-specific protein-protein interactions. Proc. Natl. Acad. Sci. USA 95:10972-10977, 1998. |
9724814 |
Naren, A.P., D.J. Nelson, W. Xie, B. Jovov, J. Pevsner, M.K. Bennett, D.J. Benos, M.W. Quick and K.L. Kirk. Regulation of CFTR chloride channels by syntaxin and Munc-18 isoforms. Nature 390:302-305, 1997. |
9384384 |
Jilling, T. and K. L. Kirk. Cyclic AMP and chloride-dependent regulation of the apical constitutive secretory pathway in colonic epithelial cells. J. Biol. Chem. 271:4381-4387, 1996. |
8626788 |
Kirk, K.L. and Wang, W. A unified view of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter. J. Biol. Chem. 286: 12813-12819, 2011. |
21296873 |
Wang, W., J. Wu, K. Bernard, G. Li, G. Wang, M.O. Bevensee and K.L. Kirk. ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc. Natl Acad. Sci USA. 107:3888-3893, 2010 |
20133716 |
Bernard, K., W. Wang, R. Narlawar, B. Schmidt and K.L. Kirk. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J. Biol. Chem. 284:30754-30765, 2009. |
19740743 |
Wang, W., K. Bernard, G. Li and K.L. Kirk. Curcumin opens CFTR channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide binding domains. J. Biol Chem 282(7): 4533-4544, 2007. |
17178710 |
Wang, W., G. Li, J.P. Clancy and K.L. Kirk. Activating CFTR chloride channels with pore blocker analogs. J. Biol. Chem. 280(25): 23622-23630, 2005 |
15857825 |
Wang, W., C. Oliva, A. Holmgren, C. H. Lillig and K.L. Kirk. Reversible silencing of CFTR channels by glutathionylation. J. Gen. Physiol. 125:1-16, 2005. |
15657297 |
Cormet-Boyaka, E, M Jablonsky, AP Naren, PL Jackson, DD Muccio and KL Kirk. Rescuing cystic fibrosis transmembrane conductance regulator(CFTR)-processing mutants by transcomplementation. Proc. Natl. Acad. Sci. 101(21): 8221-8226, 2004. |
15141088 |
Bradbury, N., T. Jilling, G. Berta, E. Sorscher, R. Bridges and K.L. Kirk. Regulation of plasma membrane recycling by CFTR. Science 256:530-532, 1992. |
1373908 |
Ganeshan R., A Di, DJ Nelson, MW Quick and KL Kirk. The interaction between syntaxin 1A and Cystic Fibrosis Transmembrane Conductance Regulator Cl- channels is mechanistically distinct from syntaxin 1A-SNARE interactions. J. Biol. Chem. 278(5):2876-2885, 2003 |
12446687 |
Estelle Cormet-Boyaka, Anke Di, Steven Y. Chang, Anjaparavanda P. Naren, Albert Tousson, Deborah J. Nelson, and Kevin L. Kirk. CFTR chloride channels are regulated by a SNAP-23/syntaxin1A complex. Proc. Natl. Acad. Sci. 99 (19): 12477-12483,2002. |
12209004 |
Fu, J., H.J.Li, A.P. Naren and K.L. Kirk. A cluster of negative charges at the amino terminal tail of CFTR regulates ATP dependent channel gating. J. Physiol. 536(2):459-470,2001. |
11600681 |
Fu, J. and K.L. Kirk. Cysteine scanning mutagenesis reveals dual regulatory roles of the amino terminal tail of CFTR in controlling ATP-dependent channel gating. J. Biol. Chem. 276(38):35668,2001. |
11468285 |
Naren, A.P., A. Di, E. Cormet-Boyaka, P.N. Boyaka, J. McGhee, W. Zhou, J.F. Englehardt, K. Akagawa, T. Fujiwara, T. Ullrich, S., Matalon, D.J. Nelson and K.L. Kirk. Syntaxin 1A is expressed in native airway epithelial cells where it modulates CFTR Cl- -currents. J. Clin. Invest. 105(3): 377-386,2000. |
10675364 |
Naren, A.P., Cormet-Boyaka, J. Fu, M. Villian, E. Blalock, M. Quick, and K.L. Kirk. CFTR Cl channel regulation by an interdomain interaction. Science 286:544-548, 1999. |
10521352 |
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