Undergraduate |
University of Science and Technology of China |
|
1985 |
BS |
Graduate |
UT Southwestern Medical Center at Dallas |
|
1991 |
PhD |
|
Appointment Type |
Department |
Division |
Rank |
Center |
Alzheimer's Disease Center |
Alzheimer's Disease Center |
Professor |
Secondary |
Cell, Developmntl, & Integrative Biology |
Cell, Developmntl, & Integrative Biology |
Professor |
Center |
Civitan International Research Center |
Civitan International Research Center |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
Comprehensive Neuroscience Center |
Comprehensive Neuroscience Center |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Ctr for Free Radical Bio |
Ctr for Free Radical Bio |
Professor |
Center |
Ctr Neurodegeneration & Exp Ther (CNET) |
Ctr Neurodegeneration & Exp Ther (CNET) |
Professor |
Secondary |
Dept of Biomedical Engineering |
Dept of Biomedical Engineering |
Professor |
Center |
GL Ctr for Craniofacial, Oral, & Dental Disorders |
GL Ctr for Craniofacial, Oral, & Dental Disorders |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Professor |
Secondary |
Neurobiology |
Neurobiology |
Professor |
Center |
Nutrition Sciences Research |
Nutrition Obesity Res Ctr (NORC) |
Professor |
Center |
UAB Immunology Institute |
UAB Immunology Institute |
Professor |
Center |
UWIRC Microbiome Center |
UWIRC Microbiome Center |
Professor |
|
Cell, Molecular, & Developmental Biology |
Cellular and Molecular Biology Program |
Integrative Genetics Graduate Program |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Neuroscience |
Neuroscience Graduate Program |
Pathobiology and Molecular Medicine |
|
Organization Name |
Position Held |
Org Link |
Society for Free Radical Biology and Medicine (SFRBM) |
VP |
sfrbm.org |
Women in Autophagy |
member |
womeninautophagy.com |
Association for Neuron and Disease (AND) |
member |
|
Birmingham Chinese Professor Association (BCPA) |
member |
|
Society of Chinese Bioscientists in America (SCBA) |
member |
|
Chinese Biologic Investigator Society (Ray Wu society) |
member |
|
|
Publication |
PUBMEDID |
E Hervouet, J · Zhang, M · Boyer-Guittaut (2016) ROS and Epigenetics. In book: Reactive Oxygen Species in Biology and Human Health, pp.519-533 |
|
The Promise of a Golden Era for Exploring the Frontiers of Aging, Metabolism and Redox Biology J Zhang 2020 Frontiers in Aging 1, 4 |
|
New Insights into the Biology of Protein O-GlcNAcylation: Approaches and Observations T Mueller, X Ouyang, MS Johnson, WEIJUN QIAN, JC Chatham, ...2021 Frontiers in Aging 1, 5 |
|
Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches.Redox Biol. 2015;4:242-59. doi: 10.1016/j.redox.2015.01.003. Epub 2015 Jan 13. |
25618581 |
Redmann M, Darley-Usmar V, Zhang J (2016) The role of autophagy, mitophagy and lysosomal functions in modulating cellular bioenergetics and survival in the context of redox and proteotoxic damage: implications for age dependent neurodegenerative diseases. Aging and Disease 7:150-162 PMCID:PMC4809607 |
27114848 |
Zhang, J., Wang, X., Bove, K. & Xu, M. (1999). DNA fragmentation factor 45 deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J. Biol. Chem. 274:37450-37454 |
10601318 |
Zhang, J. & Xu, M. (2002). Apoptotic DNA degradation and tissue homeostasis. Trends Cell Biol 12:84-89 |
11849972 |
Zhang, J., Zhang, D., McQuade, J.S., Behbehani, M., Tsien, J. & Xu, M. (2002). C-fos regulates neuronal excitability and survival. Nature Genet 30:416-420 |
11925568 |
Zhang, J., McQuade, J.S., Vorhees, C. & Xu, M. (2002). Hippocampal expression of c-fos is not essential for spatial learning. Synapse 46:91-99 |
12211087 |
Zhang, J., Dong, M., Li, L., Fan, Y., Pathrie, P., Dong, J., Olivares-Villagom, D., Lou, D., Wells, J., Van Kaer, L., Wang, X. & Xu, M. (2003). Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc. Natl. Acad. Sci. USA 100:15782-15787 |
14663139 |
Zhang, L., Lou, D., Jiao, H., Zhang, D., Wang, X., Xia, Y., Zhang, J. & Xu, M. (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J. Neurosci. 24 3344-3354 |
15056714 |
Zhang, D., Zhang, L., Zhang, Q., Tang, Y., Lou, D., Sharp, F.R., Zhang, J. & Xu, M. (2005) Gene expression changes induced by repeated cocaine administration through the dopamine D1 receptors. Neuropsychopharmacology 30, 1443-1454. |
15770241 |
Jianhua Zhang, Lu Zhang, Hongyuan Jiao, Qi Zhang, Dongsheng Zhang, Danwen Lou, Jonathan L. Katz, and Ming Xu (2006) c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Journal of Neuroscience 26: 13287-13296 |
17182779 |
Shacka J, Lu J, Xie Z, Uchiyama Y, Roth K, Zhang J (2007) “Kainic Acid Induces Early and Transient Autophagic Stress in Mouse Hippocampus” Neuroscience letter 414, 57-60 |
17223264 |
Qianjun Li, Huashi Li, Bradley J. Blitvich and Jianhua Zhang (2007) The Aedes albopictus inhibitor of Apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosis Insect Molecular Biology. 16:93-105 |
17257212 |
Shacka J, Roth K, Zhang J (2008) The Autophagy-Lysosomal Degradation Pathway: Role in Neurodegenerative Disease and Therapy Frontiers in bioscience (review) 13:718-36 |
17981582 |
Ness J, Harvey C, W Jason, Roth K, Carroll S, Zhang, J (2007) Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. J Neuroscience Res 86:1115-24 |
18030677 |
SB Caine, M Thomsen, KI Gabriel, JS Berkowitz, LH Gold, GF Koob, S Tonegawa, J Zhang, M Xu (2007) Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knockout Mice. J Neurosci 27:13140-13150 |
18045908 |
Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG. Walls KC, Shacka JJ, Roth KA, Zhang J (2008) Lysosomal enzyme cathepsin D protects against neuronal alpha-synuclein aggregation and toxicity. Molecular Brain 1:17 |
19021916 |
Qiao L, Zhang J (2009) Effect of inhibition of lysosomal functions on proteasomal activity. Neurosci Lett 456:15-19. |
19429125 |
Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem. 2010 Apr 2;285(14):10497-507. Epub 2010 Feb 1. |
20123985 |
Schneider L, Zhang J (2010) Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease Molecular Neurodegeneration. Molecular Neurodegeneration 5:14. |
20388210 |
Jegga A, Schneider L, Ouyang X, Zhang, J (2011) Systems biology of the autophagy-lysosomal pathway. Autophagy 7:5, 1-13. |
21293178 |
Liang Q, Ouyang X, Schneider L, Zhang J. Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons. Mol Neurodegener. 2011 Jun 1;6:37. |
21631942 |
Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham JC, Hill BG, Zhang J, Landar A, Darley-Usmar VM. Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radic Biol Med. 2011 Aug 16. [Epub ahead of print] |
21872656 |
Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.Schneider L, Giordano S, Zelickson BR, Johnson M, Benavides G, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J. (2011)Free Radic Biol Med. 51:2007-2017. PMCID: PMC3208787 |
21945098 |
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.Lee J, Giordano S, Zhang J.Biochem J. 2012 Jan 15;441(2):523-40.PMID:22187934PMC3258656 |
22187934 |
Higdon AN, Benavides GA, Chacko B, Ouyang X, Johnson MS, Landar A, Zhang J, Darley-Usmar VM (2012) Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. American Journal of Physiology 302(7):H1394-409. |
22245770 |
Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin R, Zhang J, Zong WX (2012) The Class III PI3K Vps34 plays an essential role in autophagy and in the heart and liver function. PNAS. 109:2003-2008. Co-corresponding author. PMCID: PMC3277541 |
22308354 |
Jaber N, Dou Z, Lin RZ, Zhang J, Zong WX (2012) Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart. Autophagy 8:4, 1–2 |
22498475 |
Cummins TD, Higdon AN, Kramer PA, Chacko B, Riggs DW, Salabei JK, Dell’Italia LJ, Zhang J, Darley-Usmar VM, Hill BG (2012) Utilization of fluorescent probes to identify subcellular proteomes and processes regulated by lipid peroxidation products FRBM Jun;59:56-68 |
22954622 |
Klionsky et al (Zhang J as one of 1270 co-authors) (2012) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. Autophagy 8:4, 445-544 |
22966490 |
Giordano S, Jisun Lee, Darley-Usmar VM, Zhang J (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PlosOne 7(9):e44610. PMCID:PMC3435291 |
22970265 |
Hill B, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2012) Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological Chemistry 393:1485-1512 |
23092819 |
Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy, AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Boulares AH (2013) Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated DNase and the PARP-regulated DNas1L3, an ER-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. 2013 Feb 1;288(5):3460-8. |
23229555 |
Mitchell T, Bailey SM, Ballinger SW, Zhang J, Darley-Usmar VM (2013) Convergent mechanisms for mitochondrial dysfunction in metabolic disease; insights from mitochondrial therapeutics. Biochemical Society Transactions 41:127-133 |
23356271 |
Errami Y, Brim H Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares HA (2013) ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability". PlosOne 2013;8(2):e57871. |
23451280 |
Parekh VV, Wu L, Boyd KL, Williams, JA, Gaddy JA, Olivares-Villagomez D, Cover TL, Zong WZ, Zhang J, Van Kaer L (2013) Impaired autophagy, defective T cell homeostasis and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Journal of Immunity 2013 May 15;190(10):5086-101. |
23596309 |
Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold P-Y, Boyer-Guittaut M, Delage-Mourroux R (2012) Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. PlosOne 2013 May 15;8(5):e63133 |
23690988 |
Dodson M, Darley-Usmar V, Zhang J.Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling. Free Radic Biol Med. 2013 May 20. pii: S0891-5849(13)00224-4. |
23702245 |
Biochem J. 2013 Jun 17. [Epub ahead of print]Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.Liang Q, Benavides GA, Vasilopoulos A, Gius D, Darley-Usmar V, Zhang J. |
23767918 |
Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM.Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived beta-cells. Am J Physiol Endocrinol Metab. 2013 Jul 2. [Epub ahead of print] |
23820623 |
Zhang J (2013) Autophagy and mitophagy in cellular damage control. Redox Biology. 1:19-23 |
23946931 |
Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J. Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.Free Radic Biol Med. 2013 Sep 19. pii: S0891-5849(13)00609-6. doi: 10.1016/j. |
24056030 |
M Dodson, Q Liang, MS Johnson, M Redmann, N Fineberg, VM Darley-Usmar, J Zhang, Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy 9 (12), 18-30 |
24145463 |
Giordano S, Darley-Usmar V, Zhang J. (2013) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. 2: 82–90. |
24494187 |
AL Levonen, BG Hill, E Kansanen, J Zhang, VM Darley-Usmar (2014) Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics. Free Radical Biology and Medicine 71, 196-207 |
24681256 |
Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar VM, Zhang J (2014) Mitophagy mechanisms and role in human diseases. International Journal of Biochemistry and Cell biology 53:127-33 |
24842106 |
Michaël Boyer-Guittaut, Laura Poillet, Qiuli Liang, Elodie Bôle-Richard, Xiaosen Ouyang, Gloria A Benavides, Fatima-Zahra Chakrama, Annick Fraichard, Victor M Darley-Usmar, Gilles Despouy, Michèle Jouvenot, Régis Delage-Mourroux, Jianhua Zhang (2014). The role of GABARAPL1 (GEC1) in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy 10 (6), 986-1003 |
24879149 |
Chacko B, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal A, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: A new concept in translational research. Clinical Science |
24895057 |
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