Appointment Type |
Department |
Division |
Rank |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor |
Center |
Ctr for Free Radical Bio |
Ctr for Free Radical Bio |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Comprehensive Neuroscience Center |
Comprehensive Neuroscience Center |
Professor |
Center |
Nephrology Research & Training Center |
Nephrology Research & Training Center |
Professor |
Center |
Med - Cardiovascular Disease |
Ctr Cardiovasc Bio (Org Ret) |
Professor |
Center |
Nutrition Sciences Research |
Nutrition Obesity Res Ctr (NORC) |
Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Professor |
Secondary |
Cell, Developmntl, & Integrative Biology |
Cell, Developmntl, & Integrative Biology |
Professor |
|
Cellular and Molecular Biology Program |
Integrative Biomedical Sciences |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Collins HE, Zhu-Mauldin X, Marchase RB, Chatham JC. STIM1/Orai1 mediated SOCE: current perspectives and potential roles in cardiac function and pathology. Am J Physiol Heart Circ Physiol. 2013 Jun 21. [Epub ahead of print] |
23792674 |
O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM, Puckett R, Marchase RB, Chatham JC, McMahon LL. J Neurosci. 2014 Jan 1;34(1):10-21 |
24381264 |
O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM, Puckett R, Marchase RB, Chatham JC, McMahon LL. J Neurosci. 2014 Jan 1;34(1):10-21. doi: 10.1523/JNEUROSCI.4761-12.2014. |
24381264 |
Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus. Heath JM, Sun Y, Yuan K, Bradley WE, Litovsky S, Dell'Italia LJ, Chatham JC, Wu H, Chen Y. Circ Res. 2014 Mar 28;114(7):1094-102. doi: 10.1161/CIRCRESAHA.114.302968. Epub 2014 Feb 13. |
24526702 |
Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Collins HE, He L, Zou L, Qu J, Zhou L, Litovsky SH, Yang Q, Young ME, Marchase RB, Chatham JC. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1231-9. doi: 10.1152/ajpheart.00075.2014. Epub 2014 Feb 28. |
24585777 |
Protein O-GlcNAcylation and cardiovascular (patho)physiology. Marsh SA, Collins HE, Chatham JC. J Biol Chem. 2014 Dec 12;289(50):34449-56 |
25336635 |
Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice. Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, Gamble KL, Young ME. Biochim Biophys Acta. 2016 Oct;1861(10):1579-95 |
26721420 |
Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice.= Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, Gamble KL, Young ME. Biochim Biophys Acta. 2016 Oct;1861(10):1579-95. doi: 10.1016/j.bbalip.2015.12.012. Epub 2015 Dec 22. |
26721420 |
TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling. Chen J, Young ME, Chatham JC, Crossman DK, Dell'Italia LJ, Shalev A. Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H64-75. doi: 10.1152/ajpheart.00151.2016. Epub 2016 May 3. |
27199118 |
O-GlcNAcylation and neurodegeneration. Wani WY, Chatham JC, Darley-Usmar V, McMahon LL, Zhang J. Brain Res Bull. 2017 Jul;133:80-87. doi: 10.1016/j.brainresbull.2016.08.002. Epub 2016 Aug 4. |
27497832 |
O-GlcNAcylation and cardiovascular disease. Wright JN, Collins HE, Wende AR, Chatham JC. Biochem Soc Trans. 2017 Apr 15;45(2):545-553. |
28408494 |
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J. Mol Brain. 2017 Jul 19;10(1):32. |
28724388 |
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. J Mol Cell Cardiol. 2017 Sep;110:80-95. |
28736261 |
Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus. Stewart LT, Khan AU, Wang K, Pizarro D, Pati S, Buckingham SC, Olsen ML, Chatham JC, McMahon LL. J Neurosci. 2017 Aug 23;37(34):8207-8215.
|
28760863 |
Temporal partitioning of adaptive responses of the murine heart to fasting. Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME. Life Sci. 2018 Mar 15;197:30-39. |
29410090 |
Temporal partitioning of adaptive responses of the murine heart to fasting. Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME. Life Sci. 2018 Mar 15;197:30-39. |
29410090 |
Acute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover.Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins HE, Zhang J, Darley-Usmar V, Chatham JC. Am J Physiol Cell Physiol. 2019 Jun 1;316(6):C862-C875. |
30865517 |
Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins HE, Zhang J, Darley-Usmar V, Chatham JC. Acute increases in O-GlcNAc indirectly impairs mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover. Am J Physiol Cell Physiol 316: C862-C875, 2019. |
30865517 |
Bouchard B, Zhu WZ, Chatham JC, Des Rosiers C, Olson A. Glucose Flux through the Hexosamine Biosynthesis Pathway (HBP): First Characterization in an Ex Vivo Mouse Heart. J Biol Chem. 2020 doi: 10.1074/jbc.RA119.010565 PMID:1915250 |
31915250 |
Blasio MJ, Huynh N, Deo M, Dubrana LE, Walsh J, Willis A, Prakoso D, Kiriazis H, Donner, DG, Chatham JC, Ritchie RH. Defining the progression of diabetic cardiomyopathy in a mouse model of type 1 diabetes Frontiers in Physiology. 2020 Feb 20;11:124. doi: 10.3389/fphys.2020.0012 |
32153425 |
Stewart LT, Abiraman K, Chatham JC, McMahon LL. Increased O-GlcNAcylation rapidly decreases GABAAR currents in hippocampus but depresses neuronal output. Scientific Reports 10, Article number: 7494 (2020) https://doi.org/10.1038/s41598-020-63188-0 |
32366857 |
Chatham JC, Zhang J, Wende AR. Role of O-linked N-acetylglucosamine (O-GlcNAc) protein modification in cellular (patho)physiology. Physiological Reviews https://doi.org/10.1152/physrev.00043.2019 |
32730113 |
Brahma MK, Pepin ME, Ha C-M, Sun Z, Chatham JC, Habegger KM, Able ED, Paterson AJ, Young ME, Wende AR. Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. JAHA 2020; 9:e013039 https://doi.org/10.1161/JAHA.119.013039 |
32750298 |
Chatham JC, Young ME, Zhang J. Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications. Current Opinion in Pharmacology 57: 1-12, 2021 https://doi.org/10.1016/j.coph.2020.08.005 |
32937226 |
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