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Faculty Detail    
Name HUI XU
  
Campus Address VH 566 Zip 0019
Phone  (205) 975-2628
E-mail  xuhui@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Dermatology  Dermatology Professor
Secondary  Pathology Chair Office  Pathology Chair Office Assistant Professor Research
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  UAB Immunology Institute  UAB Immunology Institute Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Immunology 
Medical Scientist Training Program 

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research    http://www.aacr.org/default.aspx 
The American Association of Immunologists    http://www.aai.org/ 
The Society for Investigative Dermatology    http://www.sidnet.org/default.aspx 
 



Research/Clinical Interest
Title
The role of IL-17 in inflammation associated tumor development
Description
Immunology, inflammatory diseases in the skin, tumor.

Selected Publications 
Publication PUBMEDID
He D, Li H, Yusuf N, Elmets CA, Li J, Mountz JD, and Xu H. 2010. IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid derived suppressor cells. J Immunol. 184, 2281 -2288.   
He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. 2009. IL-17 and IFN-gamma mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses. J Immunol. 183:1463-1470.   
Hee Kyung Kim, Hong Zhang, Hui Li, Tsung-Teh Wu, Stephen Swisher, Donggou He, Lizhi Wu, Craig A. Elmets, Xiaochun Xu and Hui Xu. 2008. Slit2 inhibits the growth and metastasis of fibrosarcoma and squamous cell carcinoma. Neoplasia. 10:1411-1420.   
Yusuf N, Nasti TH, Katiyar SK, Jacobs MK, Seibert MD, Ginsburg AC, Timares L, Xu H, Elmets CA. 2008. Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis. Cancer Res. 15:3924-3930.   
Yusuf N, Nasti TH, Long JA, Naseemuddin M, Lucas AP, Xu H, Elmets CA. 2008. Protective role of TLR4 during the initiation stage of cutaneous chemical carcinogenesis TLR4 in cutaneous DMBA carcinogenesis. Cancer Research. 15:615-622.   
Hui-Chen Hsu, Ping Ar Yang, Qi Wu, Riley Myers, John Wang, Tanja Guentert, Jian Chen, John Yi, Albert Tousson, Andrea L Stanus, Thuc-vy L Le, Robin G Lorenz, Hui Xu, JayK Kolls, Robert H Carter, David D Chaplin, Robert W Williams & John D Mountz. 2008. Interleukin17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol. 9:166-175.   
He, D., Wu, L., Kyung Kim, H., Li, H., Elmets C. A., and Xu, H. 2006. CD8+ IL-17 producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J. Immunol. 177: 6852-6858.   
Hee Kyung Kim, Hongbing Guan, Guorui Zu, Hui Li, Xu Feng, Craig Elmets, Yangxin Fu and Hui Xu. 2006. High level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes primed animals. J Leukoc Biol. 76:686-695.   
Liu W, Xu D, Yang H, Xu H, Shi Z, Cao X, Takeshita S, Liu J, Teale M, Feng X. 2004. Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function. J Biol Chem. 279:54759-69.   
Barlow SC, Xu H, Weaver CT, Lindsey JR, Schoeb TR, and Bullard DC. 2004. Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes. International Immunol. 16:345-351.   
Guan H, Zu G, Xie Y, Tang H, Johnson M, Xu X, Kevil C, Xiong WC, Elmets CA, Rao Y, Wu JY, and Xu H. 2003. Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J Immunol. 171:6519-6526.   
Guan H, Zu G, Slater M, Elmets CA and Xu H. 2002. Gammadelta T cells regulate the development of hapten specific CD8+ effector T cells in contact hypersensitivity responses. J Invest Dermal. 119:137-141.   
Xu H, Bullard D, Hanson J, Slater M and Elmets CA. 2001. The role of ICAM-1 molecules in the migration of Langerhans cells in the skin and regional lymph node. Eur. J. Immunol. 31:3085-3093.    
Elmets CA. Athar M. Tebesing KA. Rothaupt D. Xu H and Mukhtar H. 1998. Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complex. Proc Natl Acad Sci U S A. 95:14915.   
Xu H, Heeger P and Fairchild RL. 1997. Distinct roles for B7-1 and B7-2 determinants during priming of effector CD8+ Tc1 and regulatory CD4+ Th2 cells for contact hypersensitivity. J. Immunol. 159: 4217.   
Xu H, Banerjee A, DiIulio NA and Fairchild RL. 1997. Development of effector CD8+ T cells in contact hypersensitivity occurs independently of CD4+ T cells. J. Immunol. 158: 4721.   
Xu H, Dilulio NA, and Fairchild RL. 1996. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized pattern of cytokine production: IFN-g producing (Tc1) effector CD8+ T cells and IL-4/IL-10 producing (Th2) negative regulatory CD4+ T cells. J. Exp. Med. 183: 1001.   
 

Keywords
T cells, dendritic cells, cytokines, tumor suppressor