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Faculty Detail    
Name SHI WEI
MD, PhD		  
Campus Address HSB 138
Phone
E-mail  swei@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Womens Health  Womens Health Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He obtained additional clinical subspecialty training at Emory, Mt. Sinai and Harvard Universities. Dr. Wei is board certified in Anatomic and Clinical Pathology. He joined the faculty at UAB in July, 2008 and is currently a Tenured Professor. Dr. Wei is currently Associate Division Director of Anatomic Pathology and heads the Surgical Pathology Section.

Society Memberships
Organization Name Position Held Org Link
American Medical Association  Member  http://www.ama-assn.org 
American Society of Clinical Pathology  Fellow  http://ascp.org 
Arthur Purdy Stout Society  Member  http://www.apssociety.com/ 
Association of Directors of Anatomic and Surgical Pathology  Member  http://www.adasp.org 
Chinese American Pathologists Association  Member  https://www.capa-ht.org/ 
College of American Pathologists  Alabama Delegate, CAP House of Delegates  http://www.cap.org 
Digital Pathology Association  Member  https://digitalpathologyassociation.org/ 
International Skeletal Society  Member  http://www.internationalskeletalsociety.com 
International Society of Bone and Soft Tissue Pathology  Member  http://www.isbstp.org 
International Society of Breast Pathology  Member  https://isbpath.org/ 
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Research/Clinical Interest
Title
Description
Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, muskuloskeletal and genitourinary pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, evaluation of prognostic factors in breast cancer and malignant bone tumors, and tumor bone metastasis. He has published more than 130 manuscripts in these areas in some of the leading peer-reviewed journals, of which he first- or senior-authored approximately two-thirds. Dr. Wei is a Scientist at UAB Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center and a Senior Scientist at UAB Comprehensive Cancer Center, Experimental Therapeutics Program.

Selected Publications 
Publication PUBMEDID
Tian W, Dorn D, Wei S, Shah RB, Sanders RD, Gordetsky J. GATA3 Expression in Benign Prostate Glands with Radiation Atypia: a Diagnostic Pitfall. Histopathology. Histopathology. 2017 Mar 17. doi: 10.1111/his.13214. [Epub ahead of print]  28316088  
Li R, Zhang K, Siegal GP, Wei S. Clinicopathologic Factors Associated with Survival in Patients with Breast Cancer Brain Metastasis. Hum Pathol. 2017 Apr 17. pii: S0046-8177(17)30109-0. doi: 10.1016/j.humpath.2017.03.022. [Epub ahead of print]  28428107 
Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L. Diagnostic Utility of IDH1/2 Mutations to Distinguish Dedifferentiated Chondrosarcoma from Undifferentiated Pleomorphic Sarcoma of Bone. Hum Pathol. 2017 May 25. pii: S0046-8177(17)30172-7. doi: 10.1016/j.humpath.2017.05.015. [Epub ahead of print]  28552826 
Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, Yang WH, Cui R, Liu R, Wang D. MicroRNA-200c and 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res. 2017 Jun 21;19(1):73. doi: 10.1186/s13058-017-0858-x  28637482 
Li R, Zhang K, Siegal GP, Wei S. Clinical and pathological factors related to brain relapse-free survival in breast cancer patients-reply. Hum Pathol. 2017 Jun 24. pii: S0046-8177(17)30229-0. doi: 10.1016/j.humpath.2017.05.028. [Epub ahead of print]  28655640 
Zhou Y, Wei S. Not Your Typical Renal Cyst. Am J Med. 2017 Jul 4. pii: S0002-9343(17)30637-X. doi: 10.1016/j.amjmed.2017.06.006. [Epub ahead of print]  28687266 
Wei S, Qian X, Henderson-Jackson EB, Bui, M. Soft Tissue Tumor Immunohistochemistry Update: Illustrative Examples of Diagnostic Pearls to Avoid Pitfalls. Arch Pathol Lab Med. 2017 Aug;141(8):1072-1091. doi: 10.5858/arpa.2016-0417-RA.  28745570 
Ullman D, Gordetsky J, Siegal GP, Prieto-Granada GN, Wei S, Stevens TM. PAX8 expression in solitary fibrous tumor: A potential diagnostic pitfall. Appl Immunohistochem Mol Morphol. 2017 Jul 26. doi: 10.1097/PAI.0000000000000561. [Epub ahead of print]  28749793  
Necchi A, Eigl BJ, Yang ES, Bae S, Chandrashekar D, Chen D, Naik G, Mehta A, Giannatempo P, Colecchia M, Gordetsky J, Wei S, Cooper T, Varambally S, Sonpavde G. Gene expression profiling of advanced penile squamous cell carcinoma receiving cisplatin-based chemotherapy improves prognostication and identifies potential therapeutic targets. Eur Urol Focus. 2016 Aug 27. pii: S2405-4569(16)30109-2. doi: 10.1016/j.euf.2016.08.001.   28753783 
Lopez L, Rodriguez MG, Siegal GP, Wei S. Extraskeletal Aneurysmal Bone Cyst: Report of a Case and Review of the Literature. Pathol Res Pract. 2017 Nov;213(11):1445-1449. doi: 10.1016/j.prp.2017.07.001. Epub 2017 Jul 6. PMID: 28756986   28756986  
Wang K, Shen T, Siegal GP, Wei S. The CD4/CD8 Ratio of Tumor-infiltrating Lymphocytes at the Tumor-host Interface Has Prognostic Value in Triple Negative Breast Cancer. Hum Pathol. 2017 Oct 6. pii: S0046-8177(17)30357-X. doi: 10.1016/j.humpath.2017.09.012. [Epub ahead of print].  28993275  
Shen T, Gao C, Zhang K, Siegal GP, Wei S. Prognostic Outcomes in Advanced Breast Cancer: The Metastasis-free Interval is Important. Hum Pathol. 2017 Oct 12. pii: S0046-8177(17)30361-1. doi: 10.1016/j.humpath.2017.10.002. [Epub ahead of print].  29031733  
Cui X, Wei S. Carcinoma in Situ Involving Sclerosing Adenosis: Seeking the Salient Histological Characteristics to Prevent Overdiagnosis. Ann Clin Lab Sci. 2017 Sep;47(5):529-534.  29066477 
Wei S, Siegal GP. Surviving at a distant site: The organotropism of metastatic breast cancer. Semin Diagn Pathol. 2017 Nov 16. pii: S0740-2570(17)30135-1. doi: 10.1053/j.semdp.2017.11.008. [Epub ahead of print].  29174933 
Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde LA, Samant RS. Conditional knockout of N-Myc and STAT Interactor Disrupts Normal Mammary Development and Enhances Metastatic Ability of Mammary Tumors. Oncogene. 2018 Jan 12. doi: 10.1038/s41388-017-0037-7. [Epub ahead of print]  29326438 
Zhang Y, Yi F, Wang L, Wang Z, Zhang N, Wang Z, Li Z, Song X, Wei S,* Cao L.* Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration. Int J Biol Sci 2018; 14(9):1081-1089. doi:10.7150/ijbs.24692. *Co-corresponding authors.  29988990 
Broadwater DR, Conant JL, Czuchlewski DR, Hall JM, Wei S, Siegal GP, Peker D. Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the Literature. Clin Lymphoma Myeloma Leuk. 2018 Aug 1. pii: S2152-2650(18)30371-9. doi: 10.1016/j.clml.2018.07.286. [Epub ahead of print]   30077697 
Kurundkar A, Gao X, Zhang K, Britt JP, Siegal GP, Wei S. Comparison of AJCC Anatomic and Clinical Prognostic Stage Groups in Breast Cancer: Analysis of 3322 Cases From a Single Institution. Clin Breast Cancer. 2018 Jul 17. pii: S1526-8209(18)30230-1. doi: 10.1016/j.clbc.2018.07.013. [Epub ahead of print].   30077697 
Sharma NS, Lal CV, Li JD, Lou XY, Viera L, Abdallah T, King R, Sethi J, Kanagarajah P, Restrepo-Jaramillo R, Sales-Conniff A, Wei S, Jackson PL, Blalock JE, Gaggar A, Xu X. The Neutrophil Chemoattractant Peptide Proline-Glycine-Proline Is Associated With Acute Respiratory Distress Syndrome (ARDS). Am J Physiol Lung Cell Mol Physiol. 2018 Aug 9. doi: 10.1152/ajplung.00308.2017. [Epub ahead of print]   30091378 
Fasciano D, Wei S, Li R, Siegal GP. Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome. Pathol Res Pract. 2018 Aug 7. pii: S0344-0338(18)30787-8. doi: 10.1016/j.prp.2018.08.003. [Epub ahead of print]   30100356 
Wu L, Yi B, Wei S, Yao D, He Y, Naik G, Bae S, Liu XM, Yang WH, Sonpavde G, Liu R, Wang L. Loss of Foxp3 and Tsc1 Accelerate Prostate Cancer Progression through a Synergistic Transcriptional and Post-translational Regulation of c-MYC. Cancer Res. 2019 Feb 7. pii: canres.2049.2018. doi: 10.1158/0008-5472.CAN-18-2049. [Epub ahead of print]   30733194 
Yang Y, Wang HX, Zhang L, Huo W, Li XD, Qi RQ, Song XY, Wei S, Gao XH, Han S, Cao L. Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect. Int J Biol Sci. 2019 Jan 1;15(3):568-578. doi: 10.7150/ijbs.29759. eCollection 2019.   30745843 
116. Li M, Liu J, Li S, Feng Y, Yi F, Wang L, Wei S,* Cao L.* Autophagy related 7 modulates tumor progression in triple-negative breast cancer. Lab Invest. 2019 Apr 15. doi: 10.1038/s41374-019-0249-2. [Epub ahead of print] *Co-corresponding authors.  30988371 
Wang K, Guo R, Siegal GP, Wei S. Inflammatory Myofibroblastic Tumor of Bone Harboring an ALK Amplification. Pathol Res Pract. 2019 Jul 13:152535. doi: 10.1016/j.prp.2019.152535. [Epub ahead of print].   31326196 
Mruthyunjayappa S, Zhang K, Zhang L, Eltoum IA, Siegal GP, Wei S. Synchronous and Metachronous Bilateral Breast Cancer: Clinicopathologic Characteristics and Prognostic Outcomes. Hum Pathol. 2019 Oct;92:1-9. doi: 10.1016/j.humpath.2019.07.008. Epub 2019 Jul 24.  31351153 
Peker D*, Wei S*, Siegal GP. Bone Pathology for Hematopathologists. Surg Pathol Clin. 2019 Sep;12(3):831-847. doi: 10.1016/j.path.2019.03.007. Epub 2019 May 22. *Contributed equally.  31352990 
Zheng L, Abdelgawwad MS, Zhang D, Xu M, Wei S, Cao W, Zheng XL. Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor. Haematologica. 2019 Nov 21. pii: haematol.2019.237396. doi: 10.3324/haematol.2019.237396. [Epub ahead of print]  31753928 
Nam H, Kundu A, Brinkley GJ, Chandrashekar DS, Kirkman RL, Chakravarthi BVSK, Orlandella RM, Norian LA, Sonpavde G, Ghatalia P, Fei F, Wei S, Varambally S, Sudarshan S. PGC1α suppresses kidney cancer progression by inhibiting collagen-induced SNAIL expression. Matrix Biol. 2020 Jan 23. pii: S0945-053X(20)30001-9. doi: 10.1016/j.matbio.2020.01.001. [Epub ahead of print]   31982456 
Nam H , Kundu A, Brinkley GJ, Chandrashekar DS, Kirkman RL, Chakravarthi BVSK, Orlandella RM, Norian LA, Sonpavde G, Ghatalia P, Fei F, Wei S, Varambally S, Sudarshan S. PGC1α Suppresses Kidney Cancer Progression by Inhibiting Collagen-Induced SNAIL Expression. Matrix Biol. 2020 Jan 23;S0945-053X(20)30001-9. doi:10.1016/j.matbio.2020.01.001. Online ahead of print.  31982456 
Liu W, Zhang Y, Wei S, Bae S, Yang WH, Smith GJ, Mohler JL, Fontham ETH, Bensen JT, Sonpavde GP, Chen GY, Liu R, Wang L. A CD24-p53 axis contributes to African American prostate cancer disparities. Prostate. 2020 Mar 13. doi: 10.1002/pros.23973. [Epub ahead of print].   32168400 
Kundu A, Nam H, Shelar S, Chandrashekar DS, Brinkley G, Karki S, Mitchell T, Livi CB, Buckhaults P, Kirkman R, Tang Y, Rowe GC, Wei S, Varambally S, Sudarshan S. PRDM16 suppresses HIF-targeted gene expression in kidney cancer. J Exp Med. 2020 Jun 1;217(6). pii: e20191005. doi: 10.1084/jem.20191005.  32251515 
Reisenbichler ES, Han G, Bellizzi A, Bossuyt V, Brock J, Cole K, Fadare O, Hameed O, Hanley K, Harrison BT, Kuba MG, Ly A, Miller D, Podoll M, Roden AC, Singh K, Sanders MA, Wei S, Wen H, Pelekanou V, Yaghoobi V, Ahmed F, Pusztai L, Rimm DL. Prospective multi-institutional evaluation of pathologist assessment of PD-1 assays for patient selection in triple negative breast cancer. Mod Pathol. 2020 Apr 16. doi: 10.1038/s41379-020-0544-x. [Epub ahead of print]   32300181 
Wang K, Hackney JR. Siegal GP, Wei S. RANKLed by the Complexity of Signaling in Metastatic Breast Cancer to the Brain. Clin Breast Cancer. Clin Breast Cancer. 2020 Apr 11. pii: S1526-8209(20)30071-9. doi: 10.1016/j.clbc.2020.04.001. [Epub ahead of print]  32381383 
Rodriguez Pena MDC, Gordetsky J, Greipp PT, Wei S, Martignoni G, Netto GJ, Harada S, Prieto Granada CN. Rare MDM2 amplification in a fat-predominan angiomyolipoma. Virchows Arch. 2020 May 15. doi: 10.1007/s00428-020-02813-9. [Epub ahead of print]  32409886 
Chen R, Qarmali M, Siegal GP, Wei S. Receptor Conversion in Metastatic Breast Cancer: Analysis of 390 Cases from a Single Institution. Mod Pathol 2020 Jul 3. doi: 10.1038/s41379-020-0615-z. Online ahead of print.   32620918 
Xu J, Hussain S, Wei S, Bao W, Zhang L. Associations of stay-at-home order and face-masking recommendation with trends in daily new cases and deaths of laboratory-confirmed COVID-19 in the United States. medRxiv. 2020 Jun 29;2020.05.01.20088237. doi: 10.1101/2020.05.01.20088237.   32637967 
I-SPY2 Trial Consortium; Douglas Yee, Angela M DeMichele, Christina Yau, Claudine Isaacs, W Fraser Symmans, Kathy S Albain, Yunn-Yi Chen, Gregor Krings, Shi Wei, Shuko Harada, Brian Datnow, Oluwole Fadare, Molly Klein, Stefan Pambuccian, Beiyun Chen, Kathi Adamson, Sharon Sams, Paulette Mhawech-Fauceglia, Anthony Magliocco, Mike Feldman, Mara Rendi, Husain Sattar, Jay Zeck, Idris T Ocal, Ossama Tawfik, Lauren Grasso LeBeau, Sunati Sahoo, Tuyethoa Vinh, A Jo Chien, Andres Forero-Torres, Erica Stringer-Reasor, Anne M Wallace, Lajos Pusztai, Judy C Boughey, Erin D Ellis, Anthony D Elias, Janice Lu, Julie E Lang, Hyo S Han, Amy S Clark, Rita Nanda, Donald W Northfelt, Qamar J Khan, Rebecca K Viscusi, David M Euhus, Kirsten K Edmiston, Stephen Y Chui, Kathleen Kemmer, John W Park, Minetta C Liu, Olufunmilayo Olopade, Brian Leyland-Jones, Debasish Tripathy, Stacy L Moulder, Hope S Rugo, Richard Schwab, Shelly Lo, Teresa Helsten, Heather Beckwith, Patricia Haugen, Nola M Hylton, Laura J Van't Veer, Jane Perlmutter, Michelle E Melisko, Amy Wilson, Garry Peterson, Adam L Asare, Meredith B Buxton, Melissa Paoloni, Julia L Clennell, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Jeffrey B Matthews, Smita M Asare, Ashish Sanil, Scott M Berry, Laura J Esserman, Donald A Berry. Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial. JAMA Oncol. 2020 Jul 23. doi: 10.1001/jamaoncol.2020.2535. Online ahead of print.   32701140 
Aldrees R, Gao X, Zhang K, Siegal GP, Wei S. Validation of the Revised 8th AJCC Breast Cancer Clinical Prognostic Staging System: Analysis of 5321 Cases from a Single Institution. Mod Pathol 2020 Aug 10. doi: 10.1038/s41379-020-00650-4. Online ahead of print.   32778677 
Wei S, Tanaka H, Kubo T, Ichikawa M, Seino Y. A multiple assay for vitamin D metabolites without high-performance liquid chromatography. Anal Biochem. 1994 Nov 1;222(2):359-65.  7864359 
Wei S, Tanaka H, Kubo T, Ono T, Kanzaki S, Seino Y. Growth hormone increases serum 1,25-dihydroxyvitamin D levels and decreases 24,25-dihydroxyvitamin D levels in children with growth hormone deficiency. Eur J Endocrinol. 1997 Jan;136(1):45-51.  9037126 
Wei S, Tanaka H, Seino Y. Vitamin D receptor. Nippon Rinsho. 1997 Apr;55 Suppl 2:512-5.  9172579  
Wei S, Tanaka H, Seino Y. Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells. Eur J Endocrinol. 1998 Oct;139(4):454-60.  9820625 
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Keywords
Breast Pathology; Muskuloskeletal Pathology; Genitourinary Pathology