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Faculty Detail    
Name SHI WEI
MD, PhD		  
Campus Address HSB 138
Phone
E-mail  swei@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Womens Health  Womens Health Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He obtained additional clinical subspecialty training at Emory, Mt. Sinai and Harvard Universities. Dr. Wei is board certified in Anatomic and Clinical Pathology. He joined the faculty at UAB in July, 2008 and is currently a Tenured Professor. Dr. Wei is currently Associate Division Director of Anatomic Pathology and heads the Surgical Pathology Section.

Society Memberships
Organization Name Position Held Org Link
United States and Canadian Academy of Pathology   Member  http://www.uscap.org 
Sigma Xi, The Scientific Research Honor Society  Member  https://www.sigmaxi.org 
International Society of Breast Pathology  Member  https://isbpath.org/ 
International Society of Bone and Soft Tissue Pathology  Member  http://www.isbstp.org 
International Skeletal Society  Member  http://www.internationalskeletalsociety.com 
Digital Pathology Association  Member  https://digitalpathologyassociation.org/ 
College of American Pathologists  Alabama Delegate, CAP House of Delegates  http://www.cap.org 
Chinese American Pathologists Association  Member  https://www.capa-ht.org/ 
Association of Directors of Anatomic and Surgical Pathology  Member  http://www.adasp.org 
Arthur Purdy Stout Society  Member  http://www.apssociety.com/ 
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Research/Clinical Interest
Title
Description
Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, muskuloskeletal and genitourinary pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, evaluation of prognostic factors in breast cancer and malignant bone tumors, and tumor bone metastasis. He has published more than 130 manuscripts in these areas in some of the leading peer-reviewed journals, of which he first- or senior-authored approximately two-thirds. Dr. Wei is a Scientist at UAB Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center and a Senior Scientist at UAB Comprehensive Cancer Center, Experimental Therapeutics Program.

Selected Publications 
Publication PUBMEDID
Abdel-Aal AK, Gaddikeri S, Saddekni S, Oser RF, Underwood E, Wei S. Primary Leiomyosarcoma of the Inferior Vena Cava Invading the Right Atrium: A Technique for Intraluminal Biopsy Through a Transvenous Approach. Vasc Endovascular Surg. 2011 Nov;45(8):743-6. Epub 2011 Sep 13.  21914679 
Bai S, Jhala N, Adsay NV, Wei S. Sclerosing Epithelioid Fibrosarcoma of the Pancreas: Report of a Case and Review of Literature with Emphasis on the Differential Diagnosis. Ann Diagn Pathol. 2013 Apr;17(2):214-6. doi: 10.1016/j.anndiagpath.2011.06.006. Epub 2011 Nov 4.  22056035 
Cheng J, Liu J, Xu D, Luo S, Wei S, Feng X. Molecular mechanisms of the biphasic effects of interferon gamma on osteoclastogenesis. J Interferon Cytokine Res. J Interferon Cytokine Res. 2012 Jan;32(1):34-45. doi: 10.1089/jir.2011.0019. Epub 2011 Dec 5.   22142221 
Wei S, Siegal GP. A 23-year-old Woman with a Right Femoral Neck Fracture. JAMA. 2011 Dec 7;306(21):2385-6. doi: 10.1001/jama.2011.1748.  22147386 
Wei S, Kragel C, Zhang K, Hameed O. Factors Associated with Residual Disease after Initial Breast-Conserving Surgery for Ductal Carcinoma in Situ. Hum Pathol. 2012 Jul;43(7):986-93. Epub 2012 Jan 4.  22221704  
Pan Z, Bland KI, Wei S. Composite Cutaneous Langerhans Cell Histiocytosis and Atypical Vascular Lesion After Radiation for Breast Carcinoma: Can Radiation Induce Langerhans Cell Histiocytosis? Dermatol Online J. 2011 Dec 15;17(12):6.  22233742 
Pan Z, Sanger WG, Bridge JA, Hunter WJ, Siegal GP, Wei S. A Novel t(6;13)(q15;q34) Translocation in a Giant Cell Reparative Granuloma (Solid Aneurysmal Bone Cyst). Hum Pathol. 2012 Jun;43(6):952-7. Epub 2012 Jan 26.  22285042 
Nunez A, Siegal GP, Reddy V, Wei S. CD138 (Syndecan-1) expression in bone-forming tumors. Am J Clin Pathol. 2012 Mar;137(3):423-8. doi: 10.1309/AJCP6V4YPFBOCYXG.  22338054 
Jules J, Ashley JW, Zhang P, Wei S, Shi Z, Liu J, Michalek SM, and Feng X. Molecular Basis of the Requirement of RANK Signaling for Interleukin-1 (IL-1)-mediated Osteoclastogenesis. J Biol Chem 2012 May 4;287(19):15728-38. Epub 2012 Mar 13.  22416138 
Bai S, Wei S, Ziober A, Yao Y, Bing Z. Sall4 and SF-1 are sensitive and specific markers in distinguishing granulosa cell tumors from yolk sac tumors. Int J Surg Pathol. 2013 Apr;21(2):121-5. doi: 10.1177/1066896912454567. Epub 2012 Jul 25.  22832114  
Xu J, Latif S, Wei S. Metastatic renal cell carcinoma presenting as gastric polyps: A case report and review of the literature. Int J Surg Case Rep. 2012 Aug 24;3(12):601-604. doi: 10.1016/j.ijscr.2012.08.009. [Epub ahead of print]  22989776 
Hussain HM, Little MD, Wei S. AIRP Best Cases in Radiologic-Pathologic Correlation: Gallbladder Carcinoma with Direct Invasion of the Liver. Radiographics. 2013 Jan-Feb;33(1):103-8. doi: 10.1148/rg.331115163.  23322830 
Kragel CP, Siegal GP, Wei S. Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation. Am J Orthop. 2013 Apr;42(4):175-8.  23630677 
Bai S, Nunez AL, Wei S, Ziober A, Yao Y, Tomaszewski JE, Bing Z. Microsatellite Instability and TARBP2 Mutation Study in Upper Urinary Tract Urothelial Carcinoma. Am J Clin Pathol. 2013 Jun;139(6):765-70. doi: 10.1309/AJCPBSLP8XHSWLOW.  23690119  
Bai S, Wei S, Ziober A, Yao Y, Bing Z. Expression of SALL4 and SF-1 in gonadoblastoma: useful markers in the identification of the invasive germ cell component. Int J Gynecol Pathol. 2013 Jul;32(4):379-83. doi: 10.1097/PGP.0b013e31826a62ee.  23722510 
Bai S, Wei S, Pasha TL, Yao Y, Tomaszewski JE, Bing Z. Immunohistochemical studies of metastatic germ-cell tumors in retroperitoneal dissection specimens: a sensitive and specific panel. Int J Surg Pathol. 2013 Aug;21(4):342-51. doi: 10.1177/1066896912471849.  23893437 
Wei S, Nagi C, Bleiwiess IJ, Jaffer S. Characteristics of Breast Carcinoma Cases with False Negative Sentinel Lymph Nodes. Clin. Breast Cancer. 2014 Jan 3. pii: S1526-8209(13)00314-5. doi: 10.1016/j.clbc.2013.12.009. [Epub ahead of print].  24581736 
Ren Z, Li Y, Hameed O, Siegal GP, Wei S. Prognostic Factors in Patients with Metastatic Breast Cancer at the Time of Diagnosis. Pathol Res Pract. 2014 May;210(5):301-6. doi: 10.1016/j.prp.2014.01.008. Epub 2014 Feb 12.  24635972 
Xu J, Wei S. Breast Implant-associated Anaplastic Large Cell Lymphoma: Review of a Distinct Clinicopatholgical Entity. Arch Pathol Lab Med. 2014 Jun;138(6):842-846.  24878027 
Xing D, Qasem SA, Owusu K, Zhang Z, Siegal GP, Wei S. Changing Prognostic Factors in Osteosarcoma: Analysis of 381 Cases from Two Institutions. Hum Pathol. 2014 Aug;45(8):1688-96. doi: 10.1016/j.humpath.2014.04.010. Epub 2014 Apr 24.  24931466 
Dodd LG, Wei S, Siegal GP. Optimal handling of bone tumor specimens. Methods Mol Biol. 2014;1180:353-68. doi: 10.1007/978-1-4939-1050-2_21.  25015159 
Wei S, Siegal GP. Round cell tumors of bone: an update on recent molecular genetic advances. Adv Anat Pathol. 2014 Sep;21(5):359-72. doi: 10.1097/PAP.0000000000000036.  25105937 
Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S. L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer. Cancer Discov. 2014 Nov;4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696. Epub 2014 Sep 2.  25182153 
Cui X, Wei S. Composite Encapsulated Papillary Carcinoma and Solid Papillary Carcinoma. Pathol Int. 2015 Mar;65(3):133-7. doi: 10.1111/pin.12239.  25545718 
Soni A, Ren Z, Hameed O, Chanda D, Morgan CJ, Siegal GP, Wei S. Breast cancer subtypes predispose the site of distant metastases. Am J Clin Pathol. 2015 Apr;143(4):471-8. doi: 10.1309/AJCPYO5FSV3UPEXS.  25779997 
Stanley J, Klepczyk L, Keene K, Wei S, Li Y, Forero A, Grizzle W, LoBuglio AF and Yang ES. PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers. Breast Cancer Res Treat. Breast Cancer Res Treat. 2015 Apr;150(3):569-79. doi: 10.1007/s10549-015-3359-6. Epub 2015 Apr 2.  25833211  
Stevens T, Kovalovsky A, Velosa C, Shi Q, Dai Q, Bell W, Wei S, Althof P, Sanmannn J, Sweeny L, Carroll W, Siegal G, Bullock M, Brandwein-Gensler M. Mammary analogue secretory carcinoma, low grade salivary duct carcinoma, and their mimickers: a comparative study. Mod Pathol. 2015 Aug;28(8):1084-100. doi: 10.1038/modpathol.2015.64.   26089091 
Li R, Zhang K, Nguyen TL, Kragel CP, Grizzle WE, Hameed O, Siegal GP, Wei S. The RANK Pathway in Advanced Breast Cancer: Does Src Play a Role? Appl Immunohistochem Mol Morphol. 2016 Jan;24(1):42-50. doi: 10.1097/PAI.0000000000000151.  26200837 
Jules J, Wang S, Shi Z, Liu J, Wei S, Xu Feng X. The IVVY Motif and Tumor Necrosis Factor Receptor Associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor kappa B (RANK) Cooperate to Induce Osteoclastogenesis. J Biol Chem. 2015 Sep 25;290(39):23738-50. doi: 10.1074/jbc.M115.667535.  26276390 
Shen T, Shi Q, Velosa C, Bai S, Thompson T, Simpson R, Wei S, Brandwein-Gensler M. Sinonasal Renal Cell-Like Adenocarcinomas: Robust Carbonic Anhydrase Expression. Hum Pathol. 2015 Nov;46(11):1598-606. doi: 10.1016/j.humpath.2015.06.017.  26299508 
Ma Y, Siegal GP, Wei S. Solitary, Adult-onset, Intraosseous Myofibroma of the Finger: Report of a Case and Review of Literature. Hand (N Y). 2015 Sep;10(3):550-4. doi: 10.1007/s11552-014-9729-4.  26330794 
Shen T, Brandwein-Gensler M, Hameed O, Siegal GP, Wei S. Characterization of Estrogen Receptor Negative/Progesterone Receptor Positive Breast Cancer. Hum Pathol. 2015 Nov;46(11):1776-84. doi: 10.1016/j.humpath.2015.07.019.   26363528 
McCleskey BC, Penedo TL, Zhang K, Hameed O, Siegal GP, Wei S. GATA3 Expression in Advanced Breast Cancer: Prognostic Value and Organ-specific Relapse. Am J Clin Pathol. 2015 Nov;144(5):756-63. doi: 10.1309/AJCP5MMR1FJVVTPK.  26486740 
Ren Z, Li Y, Shen T, Hameed O, Siegal GP, Wei S. Prognostic Factors in Advanced Breast Cancer: Race and Receptor Status Are Significant after Development of Metastasis. Pathol Res Pract. 2016 Jan;212(1):24-30. doi: 10.1016/j.prp.2015.11.003.   26616114 
Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo R-J, Lu C, Nguyen LH, Yang W-H, Lillard JW, Zhang X, Wang L and Liu R. Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells. Clin Cancer Res. 2015 Dec 28. pii: clincanres.1927.2015. [Epub ahead of print].  26712693 
Ma Y, Ren Z, Conner MG, MD, Siegal GP, Wei S. Reduced E-cadherin and Aberrant Beta-catenin Expression Are Associated with Advanced Disease in Signet Ring Cell Carcinomas. Appl Immunohistochem Mol Morphol. 2017 Jul;25(6):432-438. doi: 10.1097/PAI.0000000000000317.   26808130 
Cramer SL, Wei S, Merrow AC, Pressey JG. Gorham-Stout Disease Successfully Treated with Sirolimus and Zoledronic Acid Therapy. J Pediatr Hematol Oncol. 2016 Apr;38(3):e129-32. doi: 10.1097/MPH.0000000000000514.   26886375 
Weaver AN, Burch MB, Cooper TS, Della Manna DL, Wei S, Ojesina AI, Rosenthal EL, Yang ES. Notch signaling activation is associated with mortality and FGF1-mediated invasion in squamous cell carcinoma of the oral cavity. Mol Cancer Res. Mol Cancer Res. 2016 Jun 27. pii: molcanres.0114.2016. [Epub ahead of print]  27353029  
Wei S. Papillary lesions of the breast: an update. Arch Pathol Lab Med. 2016 Jul;140(7):628-43. doi: 10.5858/arpa.2015-0092-RA.  27362568  
Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ,Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ; I-SPY 2 Investigators. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 7;375(1):23-34. doi: 10.1056/NEJMoa1513749.  27406347 
Zhu H, Sun J, Wei S, Wang D, Brandwein M. Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review. Head Neck Pathol. 2017 Jun;11(2):146-151. doi: 10.1007/s12105-016-0747-0. Epub 2016 Aug 4.   27492446 
Weaver AN, Cooper TS, Wei S, Carroll WR, Rosenthal EL, Yang ES. DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery. Head Neck. 2016 Aug 10. doi: 10.1002/hed.24562. [Epub ahead of print]  27507640 
Ghatalia P, Yang ES, Lasseigne BN, Ramaker RC, Cooper SJ, Chen D, Sudarshan S, Wei S, Guru AS, Zhao A, Cooper T, Della Manna DL,Naik G, Myers RM, Sonpavde G. Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential NewTherapeutic Targets. PLoS One. 2016 Aug 30;11(8):e0160924. doi: 10.1371/journal.pone.0160924. eCollection 2016  27574806  
Zhao J, Yu H, Liu Y, Gibson S, Yan Z, Xu X, Gaggar A, Li P-K, Li C, Wei S, Benveniste E, Qin H. Protective Effect of Suppressing STAT3 Activity in LPS-induced Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L868-L880. doi: 10.1152/ajplung.00281.2016. Epub 2016 Sep 16.  27638904 
Shen T, Siegal GP, Wei S. Clinicopathologic Factors Associated with De Novo Metastatic Breast Cancer. Pathol Res Pract. 2016 Sep 22. pii: S0344-0338(16)30274-6. doi: 10.1016/j.prp.2016.09.007. [Epub ahead of print]  27692496 
Shen T, Zhang K, Siegal GP, Wei S. Prognostic Value of E-cadherin and B-catenin in Triple Negative Breast Cancer. Am J Clin Pathol. 2016 Oct 25. pii: aqw183. [Epub ahead of print]  2778079 
Ma Y, Siegal GP, Wei S. Reacquisition of E-cadherin Expression in Metastatic Deposits of Signet-Ring Cell Carcinoma of the Upper Gastrointestinal System: A Potential Anchor for Metastatic Deposition. J Clin Pathol. 2017 Jun;70(6):528-532. doi: 10.1136/jclinpath-2016-203959. Epub 2016 Nov 18.   27864451 
Wielgos ME, Rajbhandari R, Cooper TS, Wei S, Nozell SE, Yang ES. Let-7 Status is Crucial for PARP1 Expression in HER2-overexpressing Breast Tumors. Mol Cancer Res. 2016 Dec 28. pii: molcanres.0287.2016. doi: 10.1158/1541-7786.MCR-16-0287-T. [Epub ahead of print]  28031413 
Wei S, Siegal GP. Metastatic Organotropism: An Intrinsic Property of Breast Cancer Molecular Subtypes. Adv Anat Pathol. 2017 Jan 16. doi: 10.1097/PAP.0000000000000140. [Epub ahead of print]  28098572  
Agosto-Arroyo E, Isayeva T, Wei S, Almeida JS, Harada S. Differential Gene Expression in Breast Ductal Carcinoma In-Situ Based on HER2 Oncogene Status. Cancer Control. Cancer Control. 2017 Jan;24(1):102-110.  28178722 
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Keywords
Breast Pathology; Muskuloskeletal Pathology; Genitourinary Pathology