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Faculty Detail    
Name LINDA S. WADICHE
  
Campus Address SHEL 1006 Zip 2182
Phone  (205) 996-6414
E-mail  lwadiche@uab.edu
Other websites http://www.neurobiology.uab.edu/Faculty/Wadiche_L/Lwadiche.htm
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurobiology  Neurobiology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Medical Scientist Training Program 
Neuroscience 
Neuroscience Graduate Program 

Biographical Sketch 
Linda Overstreet Wadiche received a BS in Biology from North Park University in Chicago, IL. In 1997 she received her Ph.D. from the Department of Physiology at Northwestern University Medical School under the mentorship of Dr. N. Traverse Slater. From 1998-2004 she was a postdoctoral fellow with Dr. Gary Westbrook at the Vollum Institute, Oregon Health & Science University. Dr. Wadiche became a Research Assistant Professor at the Vollum Institute in 2004. In June of 2006 she joined the Department of Neurobiology at UAB as an Assistant Professor.



Research/Clinical Interest
Title
The function of adult generated neurons and interneurons in the dentate gyrus
Description
Most neurons in the brain are generated during embryogenesis. However, neural stem cells in discrete regions of the adult continuously produce newborn neurons that can functionally integrate by forming synapses with the existing neural circuitry. One of the regions where adult neurogenesis occurs is the dentate gyrus, an area that is involved learning and memory. My laboratory focuses on the mechanisms underlying functional maturation and synaptogenesis of newborn granule cells, the principal neurons in the dentate gyrus. We use a variety of techniques to explore how newborn neurons survive and integrate, and how these processes are modified by aging, exercise and disease.

Selected Publications 
Publication PUBMEDID
Adult-born neurons modify excitatory synaptic transmission to existing neurons.
Adlaf EW, Vaden RJ, Niver AJ, Manuel AF, Onyilo VC, Araujo MT, Dieni CV, Vo HT, King GD, Wadiche JI, Overstreet-Wadiche L.
Elife. 2017 Jan 30;6. pii: e19886. doi: 10.7554/eLife.19886. 		 28135190 
Low excitatory innervation balances high intrinsic excitability of immature dentate neurons.
Dieni CV, Panichi R, Aimone JB, Kuo CT, Wadiche JI, Overstreet-Wadiche L.
Nat Commun. 2016 Apr 20;7:11313. doi: 10.1038/ncomms11313. 		 27095423 
Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus.
Markwardt SJ, Wadiche JI, Overstreet-Wadiche LS.
J Neurosci. 2009 Dec 2;29(48):15063-72. 		 19955357 
Enhanced integration of newborn neurons after neonatal insults.
Pugh P, Adlaf E, Zhao CS, Markwardt S, Gavin C, Wadiche J, Overstreet-Wadiche L.
Front Neurosci. 2011 Mar 30;5:45. 		 21490706 
Ivy/Neurogliaform interneurons coordinate activity in the neurogenic niche.
Markwardt SJ, Dieni CV, Wadiche JI, Overstreet-Wadiche L
Nat Neurosci. 2011 Oct 9;14(11):1407-9 		 21983681  
Dynamic functions of GABA signaling during granule cell maturation.
Dieni CV, Chancey JH, Overstreet-Wadiche LS.
Front Neural Circuits. 2013 Jan 8;6:113. doi: 10.3389/fncir.2012.00113. eCollection 2012. 		 23316139 
GABA depolarization is required for experience-dependent synapse unsilencing in adult-born neurons.
Chancey JH, Adlaf EW, Sapp MC, Pugh PC, Wadiche JI, Overstreet-Wadiche LS.
J Neurosci. 2013 Apr 10;33(15):6614-22.  		 23575858 
Distinct determinants of sparse activation during granule cell maturation.
Dieni CV, Nietz AK, Panichi R, Wadiche JI, Overstreet-Wadiche L.
J Neurosci. 2013 Dec 4;33(49):19131-42.  		 24305810 
Hilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells.
Chancey JH, Poulsen DJ, Wadiche JI, Overstreet-Wadiche L.
J Neurosci. 2014 Feb 5;34(6):2349-54. doi: 10.1523/JNEUROSCI.3620-13.2014. 		 24501373 
 

Keywords
synapse, neurogenesis, epilepsy, hippocampus, inhibition