Back to Main

Faculty Detail    
Name BRADFORD A. WOODWORTH
  
Campus Address FOT 1158 Zip 3412
Phone  (205) 801-7801
E-mail  bwoodwo@uab.edu
Other websites
Career Advisor     

Education
Medical School  Tulane University School of Medicine    2001  MD 
Graduate  Medical University of South Carolina Medical Center    2002  Surgery 
Residency  Medical University of South Carolina Medical Center    2006  Otolaryngology 
Fellowship  University of Pennsylvania Hospital    2007  Rhinology  


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Primary  Otolaryngology Chair Office  Otolaryngology Chair Office Professor
Secondary  Surgery - General Surgery  Surgery - Gen Surg Gastrointestinal Section Professor

Biographical Sketch 
Dr. Bradford A. Woodworth is the James J. Hicks Endowed Professor in the Department of Otolaryngology, and Adjunct Professor of Neurosurgery at the University of Alabama at Birmingham (UAB) School of Medicine. He completed his bachelor’s degree at Williams College, graduated from Tulane University School of Medicine, and finished residency in Otolaryngology-Head and Neck Surgery at the Medical University of South Carolina. Dr. Woodworth obtained fellowship training in Rhinology at the University of Pennsylvania. Professor Woodworth is a surgeon-scientist and academic leader. He serves as a Senior Scientist in the Gregory Fleming James Cystic Fibrosis Research Center where he directs the UAB Rhinology Research Laboratory. He has procured over $6 million in grant funding, including an NIH R01 grant. Dr. Woodworth's research focuses on improving mucociliary clearance in chronic sinusitis. He is internationally recognized for his research regarding management paradigms for cystic fibrosis sinus disease, pioneering techniques for cerebrospinal fluid leak/skull base defect repair and skull base surgery, innovative methods to improve Draf III frontal sinusotomy patency, and inventing the revolutionary methods for the transnasal endoscopic management of frontal sinus trauma. He continually challenges established medical and surgical treatment paradigms by generating, testing, and then publishing inventive methods to improve clinical outcomes for patients with sinus and skull base disorders. Dr. Woodworth has lectured on endoscopic sinus and skull base surgery throughout the world. He has an h-index of 55 with over 10000 citations of his works, and has published over 200 journal articles, 45 chapters, and two Rhinology textbooks. He and his mentored students/residents have been honored with numerous prestigious awards, such as the Triological Society’s Edmund Prince Fowler Award for best thesis; the American Rhinologic Society’s Young Physician-Scientist Award, Cottle Award, and Basic Science awards; and the American Academy of Otolaryngology Medical Student Research Award.

Society Memberships
Organization Name Position Held Org Link
American College of Surgeons  Fellow    
Triological Society  Fellow   
 



Research/Clinical Interest
Title
Chloride secretagogues for acquired CFTR dysfunction in chronic rhinosinusitis,Pathophysiologic Mechanisms in Chronic Rhinosinusitis
Description
The major goals of the first project is to provide a means to understand the pathogenic mechanism underlying CRS, and a new therapeutic strategy for restoring and/or increasing CFTR activity in sinus and nasal epithelium. The major goals of the second award provides ongoing research support for several long-term objectives: 1) Develop a human sinonasal mucosa tissue bank from patients undergoing endoscopic sinus surgery for future investigations into expression patterns of innate and adaptive immunity proteins, 2) Use transgenic mouse knockouts to specifically address gene product involvement in sinonasal mucosal inflammation and mucociliary dysfunction, 3) Develop potential therapies to enhance mucociliary clearance

Selected Publications 
Publication PUBMEDID
Cho DY, Zhang S, Norwood TG, Skinner D, Hollis TA, Ehrhardt ML, Yang LC, Lim DJ, Grayson JW, Lazrak A, Matalon S, Rowe SM, Woodworth BA. Hypoxia-induced cystic fibrosis transmembrane conductance regulator dysfunction is a universal mechanism underlying reduced mucociliary transport in sinusitis. Int Forum Allergy Rhinol. 2024 Jun;14(6):1058-1069. doi: 10.1002/alr.23309. Epub 2023 Dec 11.2023 Dec 11. doi: 10.1002/alr.23309. PMID: 38073611  38073611 
Cho DY, Rivers NJ, Lim DJ, Zhang S, Skinner D, Yang L, Menon AJ, Kelly OJ, Jones MP, Bicknell BT, Grayson JW, Harris E, Rowe SM, Woodworth BA. Glutathione and bicarbonate nanoparticles improve mucociliary transport in cystic fibrosis epithelia. Int Forum Allergy Rhinol. 2024 Jun;14(6):1026-1035. doi: 10.1002/alr.23301. Epub 2023 Nov 17.2023 Nov 17. doi: 10.1002/alr.23301. PMID: 37975554  37975554 
Cho DY, Zhang S, Skinner D, Koch CG, Smith MJ, Lim DJ, Grayson JW, Tearney GJ, Rowe SM, Woodworth BA. Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways. J Cyst Fibros. 2023 Nov;22(6):1113-1119. doi: 10.1016/j.jcf.2023.09.002. Epub 2023 Sep 12. PMID: 37704464  37704464 
Cho DY, Zhang S, Skinner DF, Lim DJ, Banks C, Grayson JW, Tearney GJ, Rowe SM, Woodworth BA. Ivacaftor restores delayed mucociliary transport caused by Pseudomonas aeruginosa-induced acquired cystic fibrosis transmembrane conductance regulator dysfunction in rabbit nasal epithelia. Int Forum Allergy Rhinol. 2022 May;12(5):690-698. doi: 10.1002/alr.22907. Epub 2021 Oct 26. PMID: 34704673
 		 34704673 
Cho DY, Zhang S, Lazrak A, Skinner D, Thompson HM, Grayson J, Guroji P, Aggarwal S, Bebok Z, Rowe SM, Matalon S, Sorscher EJ, Woodworth BA. LPS decreases CFTR open probability and mucociliary transport through generation of oxygen species. Redox Biol. 2021 Apr 30;43:101998. doi: 10.1016/j.redox.2021.101998. Online ahead of print. PMID: 33971543  33971543 
 

Keywords
chronic rhinosinusitis, sinus research