Undergraduate |
Birzeit University, Ramallah, Palestine |
|
1996 |
B.S |
Graduate |
Bergen University, Bergen, Norway |
|
1998 |
M.S |
Graduate |
Emory University, Atlanta, GA |
|
Ph.D |
2002 |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Microbiology |
Microbiology |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Secondary |
Chemistry |
Chemistry |
Associate Professor |
Center |
Center for AIDS Research |
Center for AIDS Research |
Professor |
|
Biochemistry and Structural Biology |
Microbiology |
|
Publication |
PUBMEDID |
Constance Agamasu, Ruba H. Ghanam and Jamil S. Saad (2015). “Structural and biophysical characterization of the interactions between calmodulin and the pleckstrin homology domain of Threonine kinase Akt. J. Biol. Chem, in press. |
|
Jamil S. Saad, Jaime Miller, Janet Tai, Andrew Kim, Ruba H. Ghanam, and Michael F. Summers. (2006) “Structural Basis for Targeting HIV-1 Gag proteins to the Plasma Membrane for Virus Assembly”, Proc. Natl. Acad. Sci. USA, 103, 11364-11369 (Highlighted on the cover). |
16840558 |
Jamil S. Saad, Erin Loeliger, Paz Luncsford, Mellisa Liriano, Janet Tai, Andrew Kim, Jaime Miller, Anjali Joshi, Eric O. Freed and Michael F. Summers (2007). “Point Mutations in the HIV-1 Matrix Protein Turn off the Myristyl Switch”, J. Mol. Biol., 366, 574-585 (Illustrated on the cover). |
17188710 |
Jamil S. Saad, Sherimay D. Ablan, Ruba H. Ghanam, Andrew Kim, Kalola Andrews, Kunio Nagashima, Eric O. Freed, and Michael F. Summers (2008). “Structure of the myristylated HIV-2 MA protein and the role of PI(4,5)P2 in membrane targeting”, J. Mol. Biol., 382, 434-347. |
18657545 |
Jamil S. Saad, Giovanni Natile, and Luigi G. Marzilli (2009) “Origins of the Distortions in the Base Pair Step Adjacent to Platinum Anticancer Drug-DNA Adducts. Fundamental NMR Solution Studies Utilizing Right-Handed Cross-Link Models Having 5'- and 3'-Flanking Residues”, J. Am. Chem. Soc., ”, 131, 12314-12324. |
19655752 |
Hamard-Peron, E., Juilliard, F., Jamil S. Saad, Roy, C., Roingeard, P., Michael F. Summers, Darlix, JL., Picart, C. and D. Muriaux (2010). “Targeting of MuLV Gag to the Plasma Membrane is Mediated by PI(4,5)P2/PS and a polybasic region in the Matrix. J. Virol, 84, 503-515. |
19828619 |
Kathleen G. Valentine, Ronald Peterson, Jamil S. Saad, Michael F. Summers, Xianzhong Xu, James B. Ames, and A. Joshua Wand (2010). “Reverse micelle encapsulation of membrane anchored proteins for solution NMR studies”. Structure, 18, 9-16. |
20152148 |
Emily L. Fledderman, Ken Fujii, Ruba H. Ghanam, Kayoko Waki, Peter E. Prevelige, Eric O. Freed, and Jamil S. Saad (2010) “Myristate Exposure in the HIV-1 Matrix Protein is Modulated by pH”. Biochemistry, 49, 9551-9562. |
20886905 |
Ruba H. Ghanam, Timothy Fernandez, Emily Fledderman, and Jamil S. Saad (2010) “Binding of Calmodulin to the HIV-1 Matrix Protein Triggers Myristate Exposure”. J. Biol. Chem., 285, 41911-41920. |
20956522 |
Jamil S. Saad, Michele Benedetti, Giovanni Natile, and Luigi G. Marzilli (2011). “NMR Studies of Models Having the Pt(d(GpG)) 17-Membered Macrocyclic Ring Formed in DNA by Platinum Anticancer Drugs. Pt Complexes with Bulky Chiral Diamine Ligands”, Inorg. Chem., 50, 4559-4571. |
21510625 |
Alexandra B. Samal, Ruba H. Ghanam, Timothy F. Fernandez, Eric B. Monroe and Jamil S. Saad (2011). “NMR, Biophysical and Biochemical Studies Reveal the Minimal Calmodulin-Binding Domain of the HIV-1 Matrix Protein”. J. Biol. Chem., 286, 33533-33543. |
21799007 |
Jamil S. Saad, Patricia A. Marzilli, Francesco P. Intini, Giovanni Natile, and Luigi G. Marzilli (2011) “Single-stranded Oligonucleotide Adducts Formed by Pt Complexes Favoring Left-handed Base Canting. Steric Effect of Flanking Residues and Relevance to DNA Adducts Formed by Pt Anticancer Drugs”. Inorg. Chem., 50, 8608-8620. |
21819051 |
Altaira D. Dearborn, Michael S. Spilman, Priyadarshan K. Damle, Jenny R. Chang, Eric B. Monroe, Jamil S. Saad, Gail E. Christie and Terje Dokland (2011) “The Staphylococcus aureus pathogenicity island 1 protein gp6 functions as an internal scaffold during capsid size determination”, J. Mol. Biol., 412, 710-722. |
21821042 |
Ruba H. Ghanam, Alexandra B. Samal, Timothy F. Fernandez, Jamil S. Saad (2012). “Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly”. Invited Review in Frontiers in Microbiology, 3, 55. |
22363329 |
Juan Calix, Jamil S. Saad, Alison Brady, Moon Nahm (2012). ‘Structural Characterization of Streptococcus pneumonia serotype 9A Capsule Polysaccharide Reveals the Role of the Glycosyl 6-O-acetyltransferase wcjE’ in Serotype 9V Capsule Biosynthesis and Immunogenicity”, J. Biol. Chem, 287, 13996-14003. |
22367197 |
Jiri Vlach and Jamil S. Saad (2013). “Trio Engagement via Plasma Membrane Phospholipids and the Myristoyl Moiety Governs HIV-1 MA Binding to Bilayers”, Proc. Natl. Acad. Sci. USA, 110, 3525-3530. |
23401539 |
Timothy F. Fernandez,‡ Alexandra B. Samal,‡ Gregory J. Bedwell, Yabing Chen, and Jamil S. Saad (2013). “Characterization of the interactions between the death domain of Fas receptor and calmodulin”. J. Biol. Chem., 288, 21898-21908. (‡ Authors contributed equally to this work). |
23760276 |
Melissa B Oliver, Mark PG van der Linden, SA Küntzel, Jamil S. Saad, Moon H. Nahm (2013). “Discovery of Streptococcus pneumoniae Serogroup 6 Variants with Glycosyltransferases Synthesizing Two Differing Repeating Units”. J. Biol. Chem, 288, 25976-25985. |
23897812 |
Juan J. Calix, Allison M. Brady, Victor Du, Jamil S. Saad, and Moon H. Nahm (2014). “Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylation”. J. Clin. Micro. 52, 758-765. |
24352997 |
Jiri Vlach,‡ Alexandra B. Samal,‡ and Jamil S. Saad (2014). “Solution structure of calmodulin bound to the binding domain of the HIV-1 matrix protein”, J. Biol. Chem., 289, 8697-8705. (‡ Authors contributed equally to this work) |
24500712 |
Jiri Vlach and Jamil S. Saad (2015). “Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane during virus assembly”. Frontiers of Microbiology, 6, 232. |
25852680 |
Ayala Lampel, Yaron Bram, Anat Ezer, Ronit Shaltiel-Kario, Jamil S. Saad, Eran Bacharach, and Ehud Gazit (2015). “Targeting the Early Step of Building Block Organization in Viral Capsid Assembly”. ACS. Chem. Biol., 10, 1785-1790 |
25997366 |
Jamil S. Saad and Delphine M. Muriaux (2015). “Role of lipids in virus assembly”. Frontiers of Microbiology, 6, 410. |
25999935 |
Bliss J. Chang, Alexandra B. Samal, Jiri Vlach, Timothy F. Fernandez, Dewey Brook, Peter E. Prevelige Jr., and Jamil S. Saad (2016). “Identification of the Calmodulin-Binding Domains of Fas Death Receptor”. PLoS One, 11, e0146493. |
26735300 |
Constance Agamasu and Jamil S. Saad (2017). “The Interplay Between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt”. J. Biol. Chem., 292, 251-263. |
27872186 |
Rosanne L. L. Hill, Jiri Vlach, Jamil S. Saad, and Terje Dokland (2017). The role of Dutpase activity in derepression of sapibov1 by bacteriophage nm1. J. Mol. Biol. 429, 1570-1580. |
28400210 |
Richard E. Murphy, Alexandra B. Samal, Jiri Vlach and Jamil S. Saad (2017). “Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein”. |
29056482 |
Susan M. Watanabe, Gisselle Medina, Gunnar N. Eastep, Ruba H. Ghanam, Jiri Vlach, Jamil S. Saad, and Carol A. Carter (2018). “The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery”. J. Biol. Chem. 293, 18841-18853. (PMID: 30309982; PMCID: PMC6295721) |
30309982 |
Jiri Vlach, Gunnar N. Eastep, Ruba H. Ghanam, Susan M. Watanabe, Carol A. Carter, and Jamil S. Saad (2018). “Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly”. J. Biol. Chem. 293, 18828-18840. (PMC6295720) - Illustrated on the cover. |
30309983 |
Uday Tak, Jiri Vlach, Acely Garza-Garcia, Doreen William, Olga Danilchanka, Luis de Carvalho, Jamil S. Saad, and Michael Niederweis (2019). “The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties”. J. Biol. Chem. 294, 3024-3036. (PMID: 30593509; PMCID: PMC6295721) |
30593509 |
Melanie H. Wong,‡ Alexandra B. Samal,‡ Mike Lee, Jiri Vlach, Nikolai Novikov, Anita Niedziela-Majka, Joy Y. Feng, Dmitry O. Koltun, Katherine M. Brendza, Hyock Joo Kwon, Brian E. Schultz, Roman Sakowicz, Jamil S. Saad,* and Giuseppe A. Papalia* (2019). “The KN-93 molecule inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) activity by binding to Ca2+/CaM”. ‡Authors contributed equally. J. Mol. Biol. 431, 1440-1459. (PMID: 30753871) |
30753871 |
Moon H. Nahm*, Terry Brissac, Mogens Kilian, Jiri Vlach, Carlos J. Orihuela, Jamil S. Saad, Feroze Ganaie (2020). “Pneumococci Can Become Virulent by Acquiring a New Capsule From Oral Streptococci”. J. Infect. Dis., 222, 372-380. (PMID: 31605125; PMCID: PMC7457184) |
31605125 |
R. Elliot Murphy, Alexandra B. Samal, Jiri Vlach, Vicente Mas, Peter E. Prevelige, and Jamil S. Saad (2019). “Structural and biophysical characterization of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly”. J. Biol. Chem. 294, 18600-18612. (PMID: 31640987; PMCID: PMC6901326) |
31640987 |
R. Elliot Murphy and Jamil S. Saad (2020). “The interplay between HIV-1 Gag binding to the plasma membrane and Env incorporation”. Viruses, 12, 548-560. (PMID: 32429351; PMCID: PMC7291237) |
32429351 |
Feroze Ganaie, Jamil S. Saad, Lesley McGee, Andries J. van Tonder, Stephen D. Bentley, Stephanie W. Lo, Rebecca A. Gladstone, Paul Turner, Jeremy D. Keenan, Robert F. Breiman, Moon H. Nahm (2020). “A New Pneumococcal Capsule Type, 10D, Is the 100th Serotype and Has a Large cps Fragment From an Oral Streptococcus”. mBio, 11, E00937-20. (PMID: 32430472) |
32430472 |
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