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Faculty Detail    
Name JESSICA SCOFFIELD
  
Campus Address BBRB 744A Zip 2170
Phone  (205) 934-0907
E-mail  jscoff@uab.edu
Other websites
     

Education
Undergraduate  Tuskegee University    2002  B.S. Biology 
Graduate  Tuskegee University    2004  M.S. Biology 
Graduate  Auburn University    2012  Ph.D. Microbiology 
Fellowship  University of Alabama at Birmingham    2018  Oral Microbiology 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Microbiology  Microbiology Associate Professor
Secondary  Med - Pulmonary/Allergy/Critical Care  Med - Pulmonary/Allergy/Critical Care Assistant Professor
Secondary  Pediatric Dentistry  Pediatric Dentistry Assistant Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Associate Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Associate Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Associate Professor
Center  Med - Pulmonary/Allergy/Critical Care  Lung Health Center Associate Professor
Center  UAB Immunology Institute  UAB Immunology Institute Associate Professor
Center  UWIRC Microbiome Center  UWIRC Microbiome Center Associate Professor



Research/Clinical Interest
Title
The role of commensal bacteria in polymicrobial lung and oral infections.
Description
My laboratory studies the role of commensal bacteria in polymicrobial pulmonary and oral infections. Our research has led to the discovery of novel antimicrobial mechanisms used by commensal bacteria that inhibit pathogenic bacteria. Ultimately, our goal is to identify and characterize anti-infective strategies used by commensals in order to develop improved therapeutics for chronic infections.

Selected Publications 
Publication PUBMEDID
Jones LB, Kumar S, Bell CR, Peoples VA, Crenshaw BJ, Coats MT, Scoffield JA, Rowe GC, Sims B, Matthews QL. 2019. Effects of Pseudomonas aeruginosa on Microglial-Derived Extracellular Vesicle Biogenesis and Composition. Pathogens. 8, 297.   31847332 
Scoffield J, Michalek S, Harber G, Eipers P, Morrow C, Wu H. 2019. Dietary Nitrite Drives Disease Outcomes in Oral Polymicrobial Infections. Journal of Dental Research.  31219733  
Yang C, Scoffield J, Wu R, Deivanayagam C, Zou J, Wu H. 2018. Streptococcus mutans Antigen I/II Mediates Dual Species Biofilm Formation with Candida albicans. Molecular Oral Microbiology. 33 (4): 283-291.   29570954 
Scoffield JA, Duan D, Zhu F, Wu H. 2017. A Commensal Streptococcus Hijacks a Pseudomonas aeruginosa Exopolysaccharide to Promote Biofilm Formation. PLOS Pathogens. 13(4): e1006300  28448633 
Scoffield JA, Silo-Suh L. 2016. Glycerol metabolism Promotes Biofilm Formation by Pseudomonas aeruginosa. Canadian Journal of Microbiology. 62(8):704-10.   27392247 
Duan D, Scoffield JA, Zhou X, Wu H. 2016. Fine-tuned production of hydrogen peroxide promotes biofilm formation of Streptococcus parasanguinis by a pathogenic cohabitant Aggregatibacter actinomycetemcomitans. Environmental Microbiology. 18(11):4023-4036.  27348605 
Scoffield JA, Wu H. 2016. Nitrite Reductase is Critical for Pseudomonas aeruginosa Survival during Co-Infection with the Oral Commensal Streptococcus parasanguinis. Microbiology. 162(2):376-83.   26673783 
Kaushik SN, Scoffield J, Andukuri A, Alexander GC, Kim S, Choi S, Brott BC, Eleazer PD, Lee JY, Wu H, Childers NK, Jun HW, Park JH and Cheon K. 2015. Evaluation of Ciprofloxacin and Metronidazole Encapsulated Biomimetic Nanomatrix Gel on Enterococcus faecalis and Treponema denticola. Biomaterials Research. 19:9.   26257918 
Scoffield JA, Wu H. 2015. Oral streptococci and nitrite-mediated Interference of Pseudomonas aeruginosa. Infection and Immunity. 83:101–107.   25312949 
Daniels JB, Scoffield JA, Makofske J, Silo-Suh L. 2014. Impact of Glycerol-3 Phosphate Dehydrogenase on Virulence Factor Production by Pseudomonas aeruginosa. Canadian Journal of Microbiology. 57: 186–195.   25409940 
Hagins J, Scoffield JA, Suh SJ, and Silo-Suh L. 2011. Malate synthase expression is deregulated in the P. aeruginosa cystic fibrosis isolate FRD1. Canadian Journal of Microbiology. 57: 186–195.   21358759 
Hagins J, Scoffield JA, Suh SJ, and Silo-Suh L. 2010. Influence of RpoN on isocitrate lyase activity in Pseudomonas aeruginosa. Microbiology. 156: 1201-1210.   20093293 
 

Keywords
polymicrobial infections, commensal bacteria, dental caries, cystic fibrosis, nitrosative stress